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Chemistry
Canada
2025

D-Index & Metrics

Chemistry

D-Index
75
Citations
22717
World Ranking
4399
National Ranking
107

Biology and Biochemistry

D-Index
75
Citations
22775
World Ranking
5263
National Ranking
191

Research.com Recognitions

  • 2025 - Research.com Chemistry in Canada Leader Award
  • 2022 - Research.com Chemistry in Canada Leader Award

Overview

Miroslaw Cygler is affiliated with the University of Saskatchewan in Canada and conducts research primarily in the field of Biochemistry, Genetics and Molecular Biology. Their work spans multiple subfields such as Molecular Biology, Endocrinology, Genetics, Infectious Diseases, and Cell Biology.

Their research topics include:

  • Legionella and Acanthamoeba research
  • Bacterial Genetics and Biotechnology
  • SARS-CoV-2 and COVID-19 Research
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Viral Infections and Outbreaks Research
  • Cellular transport and secretion
  • Vibrio bacteria research studies

Miroslaw Cygler has contributed to numerous publications across a range of scientific journals. Notable recent papers include:

  • Disulfide Bonds Play a Critical Role in the Structure and Function of the Receptor-binding Domain of the SARS-CoV-2 Spike Antigen, 2021, Journal of Molecular Biology
  • N-terminal tyrosine of ISCU2 triggers [2Fe-2S] cluster synthesis by ISCU2 dimerization, 2021, Nature Communications
  • The KH domain facilitates the substrate specificity and unwinding processivity of DDX43 helicase, 2020, Journal of Biological Chemistry
  • The Legionella kinase LegK7 exploits the Hippo pathway scaffold protein MOB1A for allostery and substrate phosphorylation, 2020, Proceedings of the National Academy of Sciences
  • Salmonella effector SopD promotes plasma membrane scission by inhibiting Rab10, 2021, Nature Communications

Frequent publication venues where the scientist has published include:

  • Nature Communications
  • Proceedings of the National Academy of Sciences
  • mBio
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Molecular Biology

Miroslaw Cygler often collaborates with other researchers. Frequent co-authors include:

  • Andrey M. Grishin
  • Ivy Yeuk Wah Chung
  • Michal T. Boniecki
  • Natalia V. Dolgova
  • Ingrid J. Pickering

Best Publications

  • The α/β hydrolase fold

    David L. Ollis;Eong Cheah;Miroslaw Cygler;Bauke Dijkstra

  • Handbook of metalloproteins

    Albrecht Messerschmidt;R. Huber;Thomas Poulos;Karl Wieghardt

  • Bacillus thuringiensis CryIA(a) insecticidal toxin: crystal structure and channel formation.

    Pawel Grochulski;Luke Masson;Svetlana Borisova;Marianne Pusztai-Carey

  • Insights into interfacial activation from an open structure of Candida rugosa lipase.

    P. Grochulski;Yunge Li;J. D. Schrag;F. Bouthillier

  • Relationship between sequence conservation and three‐dimensional structure in a large family of esterases, lipases, and related proteins

    Miroslaw Cygler;Joseph D. Schrag;Joel L. Sussman;Michal Harel

  • Ser-His-Glu triad forms the catalytic site of the lipase from Geotrichum candidum

    Joseph D. Schrag;Yunge Li;Shan Wu;Miroslaw Cygler

  • The Structure of calnexin, an ER chaperone involved in quality control of protein folding.

    Joseph D. Schrag;John J.M. Bergeron;Yunge Li;Svetlana Borisova

  • Two conformational states of Candida rugosa lipase.

    Pawel Grochulski;Yunge Li;Joseph D. Schrag;Miroslaw Cygler

  • Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment.

    R. Coulombe;P. Grochulski;J. Sivaraman;R. Ménard

  • A Structural Basis for the Chiral Preferences of Lipases

    Miroslaw Cygler;Pawel Grochulski;Romas J. Kazlauskas;Joseph D. Schrag

  • The open conformation of a Pseudomonas lipase.

    Joseph D. Schrag;Yunge Li;Miroslaw Cygler;Dietmar Lang

  • Lipases and alpha/beta hydrolase fold.

    Joseph D. Schrag;Miroslaw Cygler

  • Recognition of a cell-surface oligosaccharide of pathogenic Salmonella by an antibody Fab fragment.

    Miroslaw Cygler;David R. Rose;David R. Bundle

  • Structural and Mechanistic Classification of Uronic Acid-Containing Polysaccharide Lyases

    Marie-Line Garron;Miroslaw Cygler

  • Analogs of reaction intermediates identify a unique substrate binding site in Candida rugosa lipase.

    Pawel Grochulski;Francois Bouthillier;Romas J. Kazlauskas;Alessio N. Serreqi

  • Structural basis for Fe-S cluster assembly and tRNA thiolation mediated by IscS protein-protein interactions.

    Rong Shi;Ariane Proteau;Magda Villarroya;Ismaïl Moukadiri

  • Structure of a calpain Ca(2+)-binding domain reveals a novel EF-hand and Ca(2+)-induced conformational changes.

    H. Blanchard;P. Grochulski;Y. Li;J.S. Arthur

  • Structure of a single-chain antibody variable domain (Fv) fragment complexed with a carbohydrate antigen at 1.7-A resolution.

    A. Zdanov;Y. Li;D. R. Bundle;Su-Jun Deng

  • Structure of rat procathepsin B: model for inhibition of cysteine protease activity by the proregion

    Miroslaw Cygler;J Sivaraman;Pawel Grochulski;René Coulombe

  • Structure and functional dynamics of the mitochondrial Fe/S cluster synthesis complex.

    Michal T. Boniecki;Sven A. Freibert;Ulrich Mühlenhoff;Roland Lill

  • Antibodies to DNA

    Wayne F. Anderson;Miroslaw Cygler;Ralph P. Braun;Jeremy S. Lee

Frequent Co-Authors

Robert J. Linhardt
Robert J. Linhardt Rensselaer Polytechnic Institute
Kalle Gehring
Kalle Gehring McGill University
John S. Mort
John S. Mort McGill University
David Y. Thomas
David Y. Thomas McGill University
Zongchao Jia
Zongchao Jia Queen's University
Thierry Vernet
Thierry Vernet French Alternative Energies and Atomic Energy Commission (CEA)
Yeong Shik Kim
Yeong Shik Kim Seoul National University
David R. Bundle
David R. Bundle University of Alberta
Joel L. Sussman
Joel L. Sussman Weizmann Institute of Science
Yun Li
Yun Li University of North Carolina at Chapel Hill

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