World's Best Scientists 2026 revealed!
Zongchao Jia

Zongchao Jia

D-Index & Metrics

Chemistry

D-Index
58
Citations
13971
World Ranking
10511
National Ranking
282

Biology and Biochemistry

D-Index
59
Citations
14108
World Ranking
12423
National Ranking
428

Overview

Zongchao Jia is affiliated with Queen's University in Canada and has contributed extensively to the fields of biochemistry, genetics, and molecular biology, with a research focus spanning molecular biology, genetics, organic chemistry, materials chemistry, and oncology. Their work covers multiple scientific topics, including coagulation, bradykinin, polyphosphates, angioedema, peptidase inhibition and analysis, biodegradable polymer synthesis and properties, enzyme function and inhibition, bacteriophages and microbial interactions, enzyme structure and function, and advanced biosensing and bioanalysis techniques.

Jia's recent publications demonstrate a consistent engagement with enzymatic processes, bacterial physiology, and material chemistry. Some of the notable recent papers include:

  • Polyphosphate Kinase 2 (PPK2) Enzymes: Structure, Function, and Roles in Bacterial Physiology and Virulence (2022, International Journal of Molecular Sciences)
  • A Dual-Specificity Inhibitor Targets Polyphosphate Kinase 1 and 2 Enzymes To Attenuate Virulence of Pseudomonas aeruginosa (2021, mBio)
  • Enzymatic polyethylene biorecycling: Confronting challenges and shaping the future (2023, Journal of Hazardous Materials)
  • The structure of the MICU 1-MICU 2 complex unveils the regulation of the mitochondrial calcium uniporter (2020, The EMBO Journal)
  • Modification of histidine repeat proteins by inorganic polyphosphate (2023, Cell Reports)

Jia frequently collaborates with several researchers, indicating a broad network of scientific partnerships. Regular coauthors include Jimin Zheng, Nolan Neville, Kody Klupt, Kirsten Lehotsky, and Wei-Wei Gao.

The scientist has published repeatedly in venues such as the SSRN Electronic Journal, International Journal of Molecular Sciences, iScience, bioRxiv (Cold Spring Harbor Laboratory), and mBio. Such publications highlight their engagement with fast-evolving and interdisciplinary scientific communities.

Best Publications

  • Sensitivity of secondary structure propensities to sequence differences between α‐ and γ‐synuclein: Implications for fibrillation

    Joseph A. Marsh;Vinay K. Singh;Zongchao Jia;Julie D. Forman-Kay

  • Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B.

    Zongchao Jia;David Barford;Andrew J. Flint;Nicholas K. Tonks

  • Mimicry of ice structure by surface hydroxyls and water of a β-helix antifreeze protein

    Yih-Cherng Liou;Ante Tocilj;Peter L. Davies;Zongchao Jia

  • β-Helix structure and ice-binding properties of a hyperactive antifreeze protein from an insect

    Steffen P. Graether;Steffen P. Graether;Michael J. Kuiper;Stéphane M. Gagné;Virginia K. Walker

  • Antifreeze proteins: an unusual receptor–ligand interaction

    Zongchao Jia;Peter L Davies

  • Crystal structure of calpain reveals the structural basis for Ca2+-dependent protease activity and a novel mode of enzyme activation

    Christopher M. Hosfield;John S. Elce;Peter L. Davies;Zongchao Jia

  • A Ca2+ Switch Aligns the Active Site of Calpain

    Tudor Moldoveanu;Christopher M. Hosfield;Daniel Lim;John S. Elce

  • Structural basis for the binding of a globular antifreeze protein to ice

    Zongchao Jia;Carl I. DeLuca;Heman Chao;Heman Chao;Peter L. Davies

  • Protein tyrosine phosphatases take off

    David Barford;Zongchao Jia;Zongchao Jia;Nicholas K. Tonks

  • Activation of m-Calpain (Calpain II) by Epidermal Growth Factor Is Limited by Protein Kinase A Phosphorylation of m-Calpain

    Hidenori Shiraha;Angela Glading;Jeffrey Chou;Zongchao Jia

  • Crystal structures of Escherichia coli phytase and its complex with phytate.

    Daniel Lim;Serguei Golovan;Cecil W. Forsberg;Zongchao Jia

  • Efficient antitumor immunity derived from maturation of dendritic cells that had phagocytosed apoptotic/necrotic tumor cells

    Zhuang Chen;Terence Moyana;Anurag Saxena;Robert Warrington

  • Novel structure of the conserved gram-negative lipopolysaccharide transport protein A and mutagenesis analysis.

    Michael D.L. Suits;Paola Sperandeo;Gianni Dehò;Alessandra Polissi

  • A beta-helical antifreeze protein isoform with increased activity: structural and functional insights

    Eeva K. Leinala;Peter L. Davies;Daniel Doucet;Michael G. Tyshenko

  • Small Molecule Interactions with Protein−Tyrosine Phosphatase PTP1B and Their Use in Inhibitor Design†

    Terrence R. Burke;Bin Ye;Xinjian Yan;Shaomeng Wang

  • Extracellular K+ concentration controls cell surface density of IKr in rabbit hearts and of the HERG channel in human cell lines.

    Jun Guo;Hamid Massaeli;Jianmin Xu;Zongchao Jia

  • Crystal Structure of β-Helical Antifreeze Protein Points to a General Ice Binding Model

    Eeva K. Leinala;Peter L. Davies;Zongchao Jia

  • Repair of spontaneously deamidated HPr phosphocarrier protein catalyzed by the L-isoaspartate-(D-aspartate) O-methyltransferase.

    T. V. Brennan;J. W. Anderson;Zongchao Jia;E. B. Waygood

  • The 2.0-A resolution structure of Escherichia coli histidine-containing phosphocarrier protein HPr. A redetermination.

    Zongchao Jia;J. W. Quail;E. B. Waygood;L. T. J. Delbaere

  • Chloramphenicol biosynthesis: the structure of CmlS, a flavin-dependent halogenase showing a covalent flavin-aspartate bond.

    Kateryna Podzelinska;Ryan Latimer;Anupam Bhattacharya;Leo C. Vining

  • Crystal Structures of Recombinant Rat Cathepsin B and a Cathepsin B-Inhibitor Complex IMPLICATIONS FOR STRUCTURE-BASED INHIBITOR DESIGN

    Zongchao Jia;Sadiq Hasnain;Tomoko Hirama;Xavier Lee

Frequent Co-Authors

Peter L. Davies
Peter L. Davies Queen's University
Virginia K. Walker
Virginia K. Walker Queen's University
Miroslaw Cygler
Miroslaw Cygler University of Saskatchewan
Shu Wang
Shu Wang Chinese Academy of Sciences
Jim Xiang
Jim Xiang University of Saskatchewan
Vladimir N. Uversky
Vladimir N. Uversky University of South Florida
Xiang-Yang Liu
Xiang-Yang Liu Xiamen University
Alexander F. Yakunin
Alexander F. Yakunin Bangor University
Keith Poole
Keith Poole Queen's University
Cecil W. Forsberg
Cecil W. Forsberg University of Guelph

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