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Peter A. Greer

Peter A. Greer

D-Index & Metrics

Biology and Biochemistry

D-Index
53
Citations
8919
World Ranking
16290
National Ranking
566

Overview

Peter A. Greer is affiliated with Queen's University in Canada and has contributed significantly to research in biochemistry, genetics, molecular biology, medicine, and immunology and microbiology. Their work spans multiple subfields including molecular biology, cell biology, immunology, oncology, and cellular and molecular neuroscience.

The primary focus of Greer's research includes calpain protease function and regulation, cancer immunotherapy and biomarkers, immune cell function and interaction, immune cells in cancer, hereditary neurological disorders, ubiquitin and proteasome pathways, and endoplasmic reticulum stress and disease.

Greer has published in several prominent scientific venues, with notable frequency in:

  • Cancer Research
  • Molecular Cancer Therapeutics
  • Journal of Biological Chemistry
  • Cells
  • Frontiers in Immunology

Frequent collaborators in their work include Іван Шаповалов, Danielle Harper, Brian J. Laight, Victoria Hoskin, and Pitambar Poudel.

Selected recent publications include:

  • "Calpain as a therapeutic target in cancer" (2022), Expert Opinion on Therapeutic Targets
  • "The FES Gene at the 15q26 Coronary-Artery-Disease Locus Inhibits Atherosclerosis" (2022), Circulation Research
  • "Loss of calpains-1 and -2 prevents repair of plasma membrane scrape injuries, but not small pores, and induces a severe muscular dystrophy" (2020), American Journal of Physiology-Cell Physiology
  • "Calpain activation mediates microgravity-induced myocardial abnormalities in mice via p38 and ERK1/2 MAPK pathways" (2020), Journal of Biological Chemistry
  • "Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies" (2023), Nature Communications

Best Publications

  • Disruption of the Murine Calpain Small Subunit Gene, Capn4: Calpain Is Essential for Embryonic Development but Not for Cell Growth and Division

    J. Simon C. Arthur;John S. Elce;Carol Hegadorn;Karen Williams

  • Sequential Activation of Poly(ADP-Ribose) Polymerase 1, Calpains, and Bax Is Essential in Apoptosis-Inducing Factor-Mediated Programmed Necrosis

    Rana S. Moubarak;Victor J. Yuste;Cédric Artus;Aïda Bouharrour

  • Reduced Cell Migration and Disruption of the Actin Cytoskeleton in Calpain-deficient Embryonic Fibroblasts

    Nathalie Dourdin;Amit K. Bhatt;Previn Dutt;Peter A. Greer

  • Ubiquitous calpains promote caspase-12 and JNK activation during endoplasmic reticulum stress-induced apoptosis.

    Yinfei Tan;Nathalie Dourdin;Chao Wu;Teresa De Veyra

  • Pathological Axonal Death through a MAPK Cascade that Triggers a Local Energy Deficit

    Jing Yang;Zhuhao Wu;Nicolas Renier;David J. Simon

  • Closing in on the biological functions of Fps/Fes and Fer.

    Peter Greer

  • The nucleotide sequence of the mRNA encoding the fusion protein of measles virus (Edmonston strain): a comparison of fusion proteins from several different paramyxoviruses.

    Christopher Richardson;David Hull;Peter Greer;Karl Hasel

  • Apicomplexan parasites co-opt host calpains to facilitate their escape from infected cells.

    Rajesh Chandramohanadas;Paul H. Davis;Daniel P. Beiting;Michael B. Harbut

  • m-Calpain is required for preimplantation embryonic development in mice.

    Previn Dutt;Dorothy E Croall;J Simon C Arthur;Teresa De Veyra

  • Continuous association of cadherin with β-catenin requires the non-receptor tyrosine-kinase Fer

    Gang Xu;Andrew W. B. Craig;Peter Greer;Matthew Miller

  • Ubiquitous Calpains Promote Both Apoptosis and Survival Signals in Response to Different Cell Death Stimuli

    Yinfei Tan;Chao Wu;Teresa De Veyra;Peter A. Greer

  • Characterization of elk, a brain-specific receptor tyrosine kinase.

    V Lhoták;P Greer;K Letwin;T Pawson

  • Mitochondrial Calpain-1 Disrupts ATP Synthase and Induces Superoxide Generation in Type 1 Diabetic Hearts: A Novel Mechanism Contributing to Diabetic Cardiomyopathy

    Rui Ni;Rui Ni;Dong Zheng;Dong Zheng;Sidong Xiong;David J. Hill

  • A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome.

    Simin Lu;Kohsuke Kanekura;Takashi Hara;Jana Mahadevan

  • v-Src-induced modulation of the calpain-calpastatin proteolytic system regulates transformation.

    N. O. Carragher;M. A. Westhoff;D. Riley;D. A. Potter

  • Control of vesicle fusion by a tyrosine phosphatase.

    Huong Huynh;Nunzio Bottini;Scott Williams;Vera Cherepanov

  • Cell-to-cell adhesion modulates Stat3 activity in normal and breast carcinoma cells.

    Adina Vultur;Jun Cao;Rozanne Arulanandam;James Turkson

  • Targeted Inhibition of Calpain Reduces Myocardial Hypertrophy and Fibrosis in Mouse Models of Type 1 Diabetes

    Ying Li;Jian Ma;Huaqing Zhu;Manpreet Singh

  • Calpain mediates pulmonary vascular remodeling in rodent models of pulmonary hypertension, and its inhibition attenuates pathologic features of disease

    Wanli Ma;Weihong Han;Peter A. Greer;Rubin M. Tuder

  • Calpains mediate p53 activation and neuronal death evoked by DNA damage.

    Mary Sedarous;Elizabeth Keramaris;Michael O'Hare;Edon Melloni

Frequent Co-Authors

Jody J. Haigh
Jody J. Haigh University of Manitoba
Jeremy A. Squire
Jeremy A. Squire Universidade de São Paulo
Tony Pawson
Tony Pawson University of Toronto
David S. Park
David S. Park New York University
Janet Rossant
Janet Rossant University of Toronto
Erwin F. Wagner
Erwin F. Wagner Medical University of Vienna
J. Simon C. Arthur
J. Simon C. Arthur University of Dundee
Masatsugu Ema
Masatsugu Ema Shiga University of Medical Science
Anna Huttenlocher
Anna Huttenlocher University of Wisconsin–Madison
Stuart H. Orkin
Stuart H. Orkin Harvard University

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