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D-Index & Metrics

Biology and Biochemistry

D-Index
64
Citations
12222
World Ranking
9838
National Ranking
4310

Overview

Thomas E. Smithgall is affiliated with the University of Pittsburgh in the United States and focuses on research within the fields of Medicine, Biochemistry, Genetics and Molecular Biology, and Immunology and Microbiology. Their work spreads across several subfields including Molecular Biology, Virology, Infectious Diseases, Hematology, and Immunology.

Their research explores topics such as HIV Research and Treatment, HIV/AIDS drug development and treatment, Protein Kinase Regulation and GTPase Signaling, HIV/AIDS Research and Interventions, Chronic Myeloid Leukemia Treatments, Cytokine Signaling Pathways and Interactions, and Ubiquitin and proteasome pathways.

Recent publications by Smithgall include:

  • "Behavioural immune landscapes of inflammation" (2022), published in Nature
  • "Structure, function, and inhibitor targeting of HIV-1 Nef-effector kinase complexes" (2020), published in the Journal of Biological Chemistry
  • "Nef homodimers down-regulate SERINC5 by AP-2-mediated endocytosis to promote HIV-1 infectivity" (2020), published in the Journal of Biological Chemistry
  • "PROTAC-mediated degradation of HIV-1 Nef efficiently restores cell-surface CD4 and MHC-I expression and blocks HIV-1 replication" (2024), published in Cell chemical biology
  • "Membrane-bound Merkel cell polyomavirus middle T protein constitutively activates PLCγ1 signaling through Src-family kinases" (2023), published in Proceedings of the National Academy of Sciences

Frequent co-authors collaborating with Smithgall include John J. Alvarado, Sherry T. Shu, Haibin Shi, Giancarlo Gonzalez-Areizaga, and Thomas E. Wales.

Their work appears prominently in several publication venues, including:

  • Journal of Biological Chemistry
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Biophysical Journal
  • Scientific Reports
  • Nature

Best Publications

  • Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells

    R Garcia;CL Yu;A Hudnall;R Catlett

  • A pathway of multi-chaperone interactions common to diverse regulatory proteins: estrogen receptor, Fes tyrosine kinase, heat shock transcription factor Hsf1, and the aryl hydrocarbon receptor.

    Satish C. Nair;Eric J. Toran;Ronald A. Rimerman;Scott Hjermstad

  • Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages

    Gabriela Molina;Andreas Vogt;Ahmet Bakan;Weixiang Dai

  • Phosphotyrosine-dependent coupling of Tim-3 to T-cell receptor signaling pathways.

    Judong Lee;Ee Wern Su;Chen Zhu;Sarah Hainline

  • The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells

    Agata Klejman;Steven J. Schreiner;Malgorzata Nieborowska‐Skorska;Artur Slupianek

  • SH3-mediated Hck Tyrosine Kinase Activation and Fibroblast Transformation by the Nef Protein of HIV-1

    Scott D. Briggs;Mark Sharkey;Mario Stevenson;Thomas E. Smithgall

  • Activation of Stat3 in v-Src Transformed Fibroblasts Requires Cooperation of Jak1 Kinase Activity

    Yi Zhang;James Turkson;Christin Carter-Su;Thomas Smithgall

  • Src Kinases Mediate STAT Growth Pathways in Squamous Cell Carcinoma of the Head and Neck

    Sichuan Xi;Qing Zhang;Kevin F. Dyer;Edwina C. Lerner

  • Structure and dynamic regulation of Src-family kinases.

    J. R. Engen;T. E. Wales;J. M. Hochrein;M. A. Meyn

  • Phosphorylation-dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNA.

    Alice G. Bukrinskaya;Alice G. Bukrinskaya;Anuja Ghorpade;Nina K. Heinzinger;Nina K. Heinzinger;Thomas E. Smithgall

  • A Dynamic G-Quadruplex Region Regulates the HIV-1 Long Terminal Repeat Promoter

    Rosalba Perrone;Matteo Nadai;Ilaria Frasson;Jerrod A. Poe

  • SRC family kinases mediate epidermal growth factor receptor ligand cleavage, proliferation, and invasion of head and neck cancer cells.

    Qing Zhang;Sufi M. Thomas;Sichuan Xi;Thomas E. Smithgall

  • Control of myeloid differentiation and survival by Stats.

    Thomas E Smithgall;Scott D Briggs;Steven Schreiner;Edwina C Lerner

  • Activation of STAT3 by the Src family kinase Hck requires a functional SH3 domain.

    Steven J. Schreiner;Anthony P. Schiavone;Thomas E. Smithgall

  • Phosphorylation of TNF-α converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation

    Qing Zhang;Sufi M. Thomas;Vivian Wai Yan Lui;Sichuan Xi

  • Involvement of Jak2 tyrosine phosphorylation in Bcr-Abl transformation.

    Shanhai Xie;Yan Wang;Jiaxin Liu;Tong Sun

  • HIV-1 Nef Selectively Activates Src Family Kinases Hck, Lyn, and c-Src through Direct SH3 Domain Interaction

    Ronald P. Trible;Lori Emert-Sedlak;Thomas E. Smithgall

  • Src Family Kinases Phosphorylate the Bcr-Abl SH3-SH2 Region and Modulate Bcr-Abl Transforming Activity

    Malcolm A. Meyn;Matthew B. Wilson;Fadi A. Abdi;Nathalie Fahey

  • Regio- and stereospecificity of homogeneous 3 alpha-hydroxysteroid-dihydrodiol dehydrogenase for trans-dihydrodiol metabolites of polycyclic aromatic hydrocarbons.

    T E Smithgall;R G Harvey;T M Penning

  • Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis.

    Matthew B Wilson;Steven J Schreiner;Hyun-Jung Choi;Joanne Kamens

Frequent Co-Authors

John R. Engen
John R. Engen Northeastern University
Nathanael S. Gray
Nathanael S. Gray Stanford University
Trevor M. Penning
Trevor M. Penning University of Pennsylvania
Billy W. Day
Billy W. Day University of Pittsburgh
Mathias Lösche
Mathias Lösche Carnegie Mellon University
Jennifer R. Grandis
Jennifer R. Grandis University of California, San Francisco
Robert I. Glazer
Robert I. Glazer Georgetown University Medical Center
Ronald G. Harvey
Ronald G. Harvey University of Chicago
Mario Stevenson
Mario Stevenson University of Miami
Giorgio Palù
Giorgio Palù University of Padua

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