The scientist’s investigation covers issues in Cell biology, Cancer research, Tyrosine kinase, Proto-oncogene tyrosine-protein kinase Src and Src family kinase. His Cell biology research incorporates themes from Molecular biology, Biochemistry and Kidney. Many of his research projects under Cancer research are closely connected to STAT5B with STAT5B, tying the diverse disciplines of science together.
His Tyrosine kinase research includes themes of Chronic myelogenous leukemia and Kinase. His Proto-oncogene tyrosine-protein kinase Src study combines topics in areas such as Cyclin-dependent kinase 9 and Mitogen-activated protein kinase kinase. His study looks at the relationship between SH2 domain and fields such as Kinase activity, as well as how they intersect with chemical problems.
Thomas E. Smithgall focuses on Cell biology, Proto-oncogene tyrosine-protein kinase Src, Kinase activity, Kinase and SH3 domain. His Proto-oncogene tyrosine-protein kinase Src study incorporates themes from Tyrosine kinase and Focal adhesion. His Tyrosine kinase study deals with Cancer research intersecting with Cell growth.
His Kinase activity study integrates concerns from other disciplines, such as Molecular biology, Cellular differentiation and Protein kinase domain. His studies in Kinase integrate themes in fields like Cell culture, Viral replication, Phosphorylation and Virology. SH3 domain is a subfield of Biochemistry that Thomas E. Smithgall studies.
His primary areas of investigation include Cell biology, Tyrosine kinase, Kinase, Src family kinase and Virology. His Cell biology research focuses on Proto-oncogene tyrosine-protein kinase Src in particular. His research in Tyrosine kinase intersects with topics in Myeloid, Protein kinase domain and Kinase activity.
His Kinase activity research is multidisciplinary, incorporating perspectives in Receptor tyrosine kinase and Cell growth. As a part of the same scientific study, Thomas E. Smithgall usually deals with the Kinase, concentrating on Cancer research and frequently concerns with Flt3 itd, Inhibitor resistance, Src family, Programmed cell death and Ubiquitin ligase. His work in Src family kinase addresses subjects such as SH3 domain, which are connected to disciplines such as Transformation, Enzyme and Transferase.
Thomas E. Smithgall mainly focuses on Cell biology, Tyrosine kinase, Src family kinase, Kinase and Kinase activity. Thomas E. Smithgall studies Cell biology, focusing on Signal transducing adaptor protein in particular. His study of SH2 domain is a part of Tyrosine kinase.
The Kinase study combines topics in areas such as Leukemia and Syk. Thomas E. Smithgall has researched Kinase activity in several fields, including Fms-Like Tyrosine Kinase 3, Cell growth, Proto-Oncogene Proteins c-fes, Molecular biology and Myeloid leukemia. In his research, Telomere-binding protein, Mitosis, Chromatin, Gene and Phosphorylation is intimately related to Cancer research, which falls under the overarching field of Proto-Oncogene Proteins c-hck.
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Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells
R Garcia;CL Yu;A Hudnall;R Catlett.
Cell Growth & Differentiation (1997)
A pathway of multi-chaperone interactions common to diverse regulatory proteins: estrogen receptor, Fes tyrosine kinase, heat shock transcription factor Hsf1, and the aryl hydrocarbon receptor.
Satish C. Nair;Eric J. Toran;Ronald A. Rimerman;Scott Hjermstad.
Cell Stress & Chaperones (1996)
The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells
Agata Klejman;Steven J. Schreiner;Malgorzata Nieborowska‐Skorska;Artur Slupianek.
The EMBO Journal (2002)
SH3-mediated Hck Tyrosine Kinase Activation and Fibroblast Transformation by the Nef Protein of HIV-1
Scott D. Briggs;Mark Sharkey;Mario Stevenson;Thomas E. Smithgall.
Journal of Biological Chemistry (1997)
Activation of Stat3 in v-Src Transformed Fibroblasts Requires Cooperation of Jak1 Kinase Activity
Yi Zhang;James Turkson;Christin Carter-Su;Thomas Smithgall.
Journal of Biological Chemistry (2000)
Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages
Gabriela Molina;Andreas Vogt;Ahmet Bakan;Weixiang Dai.
Nature Chemical Biology (2009)
Src Kinases Mediate STAT Growth Pathways in Squamous Cell Carcinoma of the Head and Neck
Sichuan Xi;Qing Zhang;Kevin F. Dyer;Edwina C. Lerner.
Journal of Biological Chemistry (2003)
Phosphorylation-dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNA.
Alice G. Bukrinskaya;Alice G. Bukrinskaya;Anuja Ghorpade;Nina K. Heinzinger;Nina K. Heinzinger;Thomas E. Smithgall.
Proceedings of the National Academy of Sciences of the United States of America (1996)
Control of myeloid differentiation and survival by Stats.
Thomas E Smithgall;Scott D Briggs;Steven Schreiner;Edwina C Lerner.
Structure and dynamic regulation of Src-family kinases.
J. R. Engen;T. E. Wales;J. M. Hochrein;M. A. Meyn.
Cellular and Molecular Life Sciences (2008)
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