Trevor M. Penning

Best Publications

• Role of quinones in toxicology.

  Judy L. Bolton;Michael A. Trush;Trevor M. Penning;Glenn Dryhurst

  2085
  Citations

• Increased Expression of Genes Converting Adrenal Androgens to Testosterone in Androgen-Independent Prostate Cancer

  Michael Stanbrough;Glenn J. Bubley;Kenneth Ross;Todd R. Golub

  1352
  Citations

• Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

  Lauren E. Tebay;Holly Robertson;Stephen T. Durant;Steven R. Vitale

  864
  Citations

• Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones.

  Trevor M. Penning;Michael E. Burczynski;Joseph M. Jez;Chien-Fu Hung

  863
  Citations

• Comparative anatomy of the aldo-keto reductase superfamily.

  Joseph M. Jez;Melanie J. Bennett;Brian P. Schlegel;Mitchell Lewis

  768
  Citations

• Clustering a Chemical Inventory for Safety Assessment of Fragrance Ingredients: Identifying Read-Across Analogs to Address Data Gaps.

  Mihir S. Date;Devin O’Brien;Danielle J. Botelho;Terry W. Schultz

  630
  Citations

• Molecular Endocrinology of Hydroxysteroid Dehydrogenases

  Trevor M. Penning

  582
  Citations

• Dihydrodiol dehydrogenases and polycyclic aromatic hydrocarbon activation: generation of reactive and redox active o-quinones.

  Trevor M. Penning;Michael E. Burczynski;Chien Fu Hung;Kirsten D. McCoull

  573
  Citations

• The aldo-keto reductases (AKRs): Overview

  Trevor M. Penning

  535
  Citations

• The biochemical basis for increased Testosterone production in theca cells propagated from patients with polycystic ovary syndrome

  Velen L. Nelson;Ke-nan Qin;Robert L. Rosenfield;Jennifer R. Wood

  505
  Citations

• The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative

  Bengt Persson;Yvonne Kallberg;Yvonne Kallberg;James E. Bray;Elspeth Bruford

  467
  Citations

• A new nomenclature for the aldo-keto reductase superfamily

  J M Jez;T G Flynn;T M Penning

  454
  Citations

• Aldo-Keto Reductases and Bioactivation/Detoxication

  Yi Jin;Trevor M. Penning

  451
  Citations

• Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds

  A.Kenneth MacLeod;Michael McMahon;Simon M. Plummer;Larry G. Higgins

  416
  Citations

• The aldo-keto reductase superfamily homepage.

  David Hyndman;David R Bauman;Vladi V Heredia;Trevor M Penning

  395
  Citations

• Human Cytosolic 3α-Hydroxysteroid Dehydrogenases of the Aldo-keto Reductase Superfamily Display Significant 3β-Hydroxysteroid Dehydrogenase Activity IMPLICATIONS FOR STEROID HORMONE METABOLISM AND ACTION

  Stephan Steckelbroeck;Yi Jin;Sridhar Gopishetty;Busola Oyesanmi

  391
  Citations

• Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer

  Karen E. Knudsen;Trevor M. Penning

  356
  Citations

• Human Aldo-Keto Reductases: Function, Gene Regulation, and Single Nucleotide Polymorphisms

  Trevor M. Penning;Jason E. Drury

  329
  Citations

• Resveratrol is a peroxidase-mediated inactivator of COX-1 but not COX-2: a mechanistic approach to the design of COX-1 selective agents.

  Lawrence M. Szewczuk;Luca Forti;Lucia A. Stivala;Trevor M. Penning

  323
  Citations

• Activation of polycyclic aromatic hydrocarbon trans-dihydrodiol proximate carcinogens by human aldo-keto reductase (AKR1C) enzymes and their functional overexpression in human lung carcinoma (A549) cells.

  Nisha T. Palackal;Seon Hwa Lee;Ronald G. Harvey;Ian A. Blair

  309
  Citations