Ronald G. Harvey mostly deals with Stereochemistry, Organic chemistry, Pyrene, Carcinogen and Benzopyrene. His Stereochemistry study incorporates themes from Adduct, Nucleotide and Binding site. His Pyrene research includes themes of Nucleophile and DNA.
His Carcinogen research incorporates elements of Aldo-keto reductase, Toxicology, A549 cell, Anthracene and Metabolite. His Benzopyrene research includes elements of Epoxide, RNA, Chemical synthesis, In vivo and Metabolism. His study looks at the intersection of Epoxide and topics like Diol with Deoxyribonucleoside.
His primary scientific interests are in Stereochemistry, Organic chemistry, Carcinogen, Pyrene and Epoxide. His study in Stereochemistry is interdisciplinary in nature, drawing from both Covalent bond, DNA, Anthracene, Chrysene and Adduct. His research in Anthracene focuses on subjects like Medicinal chemistry, which are connected to Ring.
The concepts of his Carcinogen study are interwoven with issues in Biological activity, DMBA, 7,12-Dimethylbenz[a]anthracene, Metabolite and Methyl group. A large part of his Pyrene studies is devoted to Benzopyrene. His study brings together the fields of Diol and Epoxide.
Ronald G. Harvey spends much of his time researching Carcinogen, Organic chemistry, Stereochemistry, Epoxide and Anthracene. His Carcinogen research is multidisciplinary, incorporating perspectives in Metabolite, Active metabolite, 7,12-Dimethylbenz[a]anthracene and Pyrene. Many of his studies on Pyrene apply to Guanine as well.
Ronald G. Harvey has researched Stereochemistry in several fields, including Adduct, Polycyclic aromatic hydrocarbon, DNA and Benzopyrene. In his study, which falls under the umbrella issue of Benzopyrene, Metabolism is strongly linked to Cell culture. His Epoxide research is multidisciplinary, incorporating elements of Diol and Picene.
The scientist’s investigation covers issues in Carcinogen, Benzopyrene, Pyrene, Biochemistry and Organic chemistry. His studies in Carcinogen integrate themes in fields like DNA, Anthracene, Enzyme, Metabolite and Stereochemistry. He has included themes like Epoxide hydrolase and Polycyclic aromatic hydrocarbon in his Stereochemistry study.
The Benzopyrene study combines topics in areas such as Cell culture, Chromatography, Deoxyguanosine and Epoxide. His Epoxide research integrates issues from Diol, Dado and Chemical synthesis. His Pyrene study frequently draws connections to adjacent fields such as Adduct.
This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.
Benzo(a)pyrene diol epoxides as intermediates in nucleic acid binding in vitro and in vivo.
IB Weinstein;AM Jeffrey;KW Jennette;SH Blobstein.
Science (1976)
Structures of benzo(a)pyrene–nucleic acid adducts formed in human and bovine bronchial explants
A. M. Jeffrey;I. B. Weinstein;K. W. Jennette;K. Grzeskowiak.
Nature (1977)
Dehydrogenation of polycyclic hydroaromatic compounds
Peter P. Fu;Ronald G. Harvey.
Chemical Reviews (1978)
Benzo[a]pyrene-nucleic acid derivative found in vivo: structure of a benzo[a]pyrenetetrahydrodiol epoxide-guanosine adduct
A. M. Jeffrey;K. W. Jennette;S. H. Blobstein;I. B. Weinstein.
Journal of the American Chemical Society (1976)
Activation of polycyclic aromatic hydrocarbon trans-dihydrodiol proximate carcinogens by human aldo-keto reductase (AKR1C) enzymes and their functional overexpression in human lung carcinoma (A549) cells.
Nisha T. Palackal;Seon Hwa Lee;Ronald G. Harvey;Ian A. Blair.
Journal of Biological Chemistry (2002)
Nucleoside adducts from the in vitro reaction of benzo[a]pyrene-7,8-dihydrodiol 9,10-oxide or benzo[a]pyrene 4,5-oxide with nucleic acids.
Jennette Kw;Jeffrey Am;Blobstein Sh;Beland Fa.
Biochemistry (1977)
Intercalation and binding of carcinogenic hydrocarbon metabolites to nucleic acids
Ronald G. Harvey;Nicholas E. Geacintov.
Accounts of Chemical Research (1988)
(+/-)-7alpha,8beta-dihydroxy-9beta,10beta-epoxy-7,8,9,10-tetrahydrobenzo(a)-pyrene is an intermediate in the metabolism and binding to DNA of benzo(a)pyrene.
H. W. S. King;M. R. Osborne;F. A. Beland;R. G. Harvey.
Proceedings of the National Academy of Sciences of the United States of America (1976)
Activated metabolites of carcinogenic hydrocarbons
Ronald G. Harvey.
Accounts of Chemical Research (1981)
Solution conformation of the (+)-cis-anti-[BP]dG adduct in a DNA duplex: intercalation of the covalently attached benzo[a]pyrenyl ring into the helix and displacement of the modified deoxyguanosine.
Monique Cosman;Carlos de los Santos;Radovan Fiala;Brian E. Hingerty.
Biochemistry (1993)
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