Harry V. Gelboin

Overview

Best Publications

• Characterization of the common genetic defect in humans deficient in debrisoquine metabolism.

  F J Gonzalez;R C Skoda;S Kimura;M Umeno

  914
  Citations

• Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions.

  A E Rettie;K R Korzekwa;K L Kunze;R F Lawrence

  786
  Citations

• Role of Human Cytochromes P450 in the Metabolic Activation of Chemical Carcinogens and Toxins

  Frank J. Gonzalez;Harry V. Gelboin

  717
  Citations

• Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine.

  T Aoyama;S Yamano;D J Waxman;D P Lapenson

  700
  Citations

• Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme.

  Byung-Joon Song;H. V. Gelboin;Sang-Shin Park;C. S. Yang

  523
  Citations

• A Microsome-dependent Binding of Benzo[a]pyrene to DNA

  Harry V. Gelboin

  473
  Citations

• Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s.

  David J. Waxman;David P. Lapenson;Toshifumi Aoyama;Harry V. Gelboin

  470
  Citations

• Activation of CYP3A4: evidence for the simultaneous binding of two substrates in a cytochrome P450 active site.

  M. Shou;J. Grogan;J. A. Mancewicz;K. W. Krausz

  467
  Citations

• Specificity of substrate and inhibitor probes for human cytochromes P450 1A1 and 1A2.

  W Tassaneeyakul;D J Birkett;M E Veronese;M E McManus

  416
  Citations

• Five of 12 forms of vaccinia virus-expressed human hepatic cytochrome P450 metabolically activate aflatoxin B1.

  Toshifumi Aoyama;Shigeru Yamano;Philip S. Guzelian;Harry V. Gelboin

  341
  Citations

• A tobacco smoke-derived nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, is activated by multiple human cytochrome P450s including the polymorphic human cytochrome P4502D6.

  Charles L. Crespi;Bruce W. Penman;Harry V. Gelboin;Frank J. Gonzalez

  333
  Citations

• The induction of a specific form of cytochrome P-450 (P-450j) by fasting.

  Junyan Hong;Jinmei Pan;Frank J. Gonzalez;Harry V. Gelboin

  295
  Citations

• Stabilization of cytochrome p450j messenger ribonucleic acid in the diabetic rat

  Byung J. Song;Tamihide Matsunaga;James P. Hardwick;Sang S. Park

  289
  Citations

• Benzo(a)pyrene metabolites: efficient and rapid separation by high-pressure liquid chromatography.

  James K. Selkirk;Robert G. Croy;Harry V. Gelboin

  280
  Citations

• Human ethanol-inducible P450IIE1: complete gene sequence, promoter characterization, chromosome mapping, and cDNA-directed expression.

  M Umeno;O W McBride;C S Yang;H V Gelboin

  278
  Citations

• Role of human cytochrome P450 3A4 and 3A5 in the metabolism of taxotere and its derivatives: enzyme specificity, interindividual distribution and metabolic contribution in human liver.

  Magang Shou;Michel Martinet;Kenneth R. Korzekwa;Kristopher W. Krausz

  262
  Citations

• Monoclonal antibodies to liver microsomal cytochrome P-450E of the marine fish Stenotomus chrysops (scup): cross reactivity with 3-methylcholanthrene induced rat cytochrome P-450.

  Sang S. Park;Haruko Miller;Alan V. Klotz;Pamela J. Kloepper-Sams

  253
  Citations

• High-pressure liquid chromatographic analysis of benzo(alpha)pyrene metabolism and covalent binding and the mechanism of action of 7,8-benzoflavone and 1,2-epoxy-3,3,3-trichloropropane.

  James K. Selkirk;Robert G. Croy;Peter P. Roller;Harry V. Gelboin

  251
  Citations

• Human P450PCN1: sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase.

  Frank J. Gonzalez;Balthazar J. Schmid;Morio Umeno;O. Wesley Mcbride

  242
  Citations

• Targeted Disruption of the Microsomal Epoxide Hydrolase Gene: MICROSOMAL EPOXIDE HYDROLASE IS REQUIRED FOR THE CARCINOGENIC ACTIVITY OF 7,12-DIMETHYLBENZ[a]ANTHRACENE

  Masaaki Miyata;Gen Kudo;Ying-Hue Lee;Tian J. Yang

  242
  Citations