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Biology and Biochemistry

D-Index
80
Citations
21971
World Ranking
4101
National Ranking
2015

Overview

Shioko Kimura is a researcher affiliated with the National Institutes of Health in the United States. Their work primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on several subfields including Pulmonary and Respiratory Medicine, Molecular Biology, Endocrinology, Diabetes and Metabolism, Epidemiology, and Nutrition and Dietetics.

Their research contributions are evidenced in various scientific topics such as Neonatal Respiratory Health Research, Congenital Heart Defects Research, Epigenetics and DNA Methylation, Liver Disease Diagnosis and Treatment, Thyroid Cancer Diagnosis and Treatment, Chronic Obstructive Pulmonary Disease (COPD) Research, and Cystic Fibrosis Research Advances.

Shioko Kimura has been involved as an author or co-author in a range of peer-reviewed publications. Notable recent papers include:

  • Differential chromatin binding of the lung lineage transcription factor NKX2-1 resolves opposing murine alveolar cell fates in vivo, 2021, Nature Communications
  • Emerging role of an immunomodulatory protein secretoglobin 3A2 in human diseases, 2022, Pharmacology & Therapeutics
  • Secretoglobin 3A2 eliminates human cancer cells through pyroptosis, 2021, Cell Death Discovery
  • Hepatocyte-specific CCAAT/enhancer binding protein α restricts liver fibrosis progression, 2024, Journal of Clinical Investigation
  • Digoxin treatment reactivates in vivo radioactive iodide uptake and correlates with favorable clinical outcome in non-medullary thyroid cancer, 2021, Cellular Oncology

Their frequent co-authors include Reiko Kurotani, Maxwell P. Lee, Yo-Taro Shirai, Shigetoshi Yokoyama, and Huaitian Liu.

Shioko Kimura's research has been published in several scientific venues, with multiple publications appearing in:

  • Cancer Research
  • Nature Communications
  • Pharmacology & Therapeutics
  • Cell Death Discovery
  • Journal of Clinical Investigation

Best Publications

  • Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor

    Pedro Fernandez-Salguero;Thierry Pineau;David M. Hilbert;Timothy McPhail

  • The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary.

    Shioko Kimura;Yoshinobu Hara;Thierry Pineau;Pedro Fernandez-Salguero

  • Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum

    L. Sussel;O. Marin;S. Kimura;J. L. R. Rubenstein

  • Characterization of the common genetic defect in humans deficient in debrisoquine metabolism.

    F J Gonzalez;R C Skoda;S Kimura;M Umeno

  • Defects in tracheoesophageal and lung morphogenesis in Nkx2.1(-/-) mouse embryos.

    Parviz Minoo;Guoshan Su;Hong Drum;Pablo Bringas

  • The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene.

    S Kimura;M Umeno;R C Skoda;U A Meyer

  • Human thyroid peroxidase: complete cDNA and protein sequence, chromosome mapping, and identification of two alternately spliced mRNAs

    S Kimura;T Kotani;O W McBride;K Umeki

  • Formation of Rathke's pouch requires dual induction from the diencephalon.

    Naoyuki Takuma;Hui Z. Sheng;Yasuhide Furuta;Jerrold M. Ward

  • The Requirement of Nkx2-1 in the Temporal Specification of Cortical Interneuron Subtypes

    Simon J.B. Butt;Vitor H. Sousa;Marc V. Fuccillo;Jens Hjerling-Leffler

  • Disruption of the DT diaphorase (NQO1) gene in mice leads to increased menadione toxicity.

    Venugopal Radjendirane;Pius Joseph;Ying Hue Lee;Shioko Kimura

  • Postmitotic Nkx2-1 controls the migration of telencephalic interneurons by direct repression of guidance receptors

    Sandrina Nóbrega-Pereira;Nicoletta Kessaris;Tonggong Du;Shioko Kimura

  • The murine Ah locus. Comparison of the complete cytochrome P1-450 and P3-450 cDNA nucleotide and amino acid sequences.

    S Kimura;F J Gonzalez;D W Nebert

  • Partial deficiency of Thyroid transcription factor 1 produces predominantly neurological defects in humans and mice

    Joachim Pohlenz;Alexandra Dumitrescu;Dorothee Zundel;Ursula Martiné

  • claudin-18, a Novel Downstream Target Gene for the T/EBP/NKX2.1 Homeodomain Transcription Factor, Encodes Lung- and Stomach-Specific Isoforms through Alternative Splicing

    Tomoaki Niimi;Kunio Nagashima;Jerrold M. Ward;Parviz Minoo

  • Nkx2-1 Represses a Latent Gastric Differentiation Program in Lung Adenocarcinoma

    Eric L. Snyder;Eric L. Snyder;Hideo Watanabe;Hideo Watanabe;Margaret Magendantz;Sebastian Hoersch

  • Tissue-specific expression of the mouse dioxin-inducible P(1)450 and P(3)450 genes: differential transcriptional activation and mRNA stability in liver and extrahepatic tissues.

    S Kimura;F J Gonzalez;D W Nebert

  • Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice

    Aime T. Franco;Roberta Malaguarnera;Samuel Refetoff;Xiao-Hui Liao

  • Targeted Disruption of the Microsomal Epoxide Hydrolase Gene: MICROSOMAL EPOXIDE HYDROLASE IS REQUIRED FOR THE CARCINOGENIC ACTIVITY OF 7,12-DIMETHYLBENZ[a]ANTHRACENE

    Masaaki Miyata;Gen Kudo;Ying-Hue Lee;Tian J. Yang

  • Targeting nuclear receptors for the treatment of fatty liver disease.

    Naoki Tanaka;Toshifumi Aoyama;Shioko Kimura;Frank J. Gonzalez

  • The progenitor zone of the ventral medial ganglionic eminence requires Nkx2-1 to generate most of the globus pallidus but few neocortical interneurons.

    Pierre Flandin;Shioko Kimura;John L. R. Rubenstein

Frequent Co-Authors

Frank J. Gonzalez
Frank J. Gonzalez National Institutes of Health
Jerrold M. Ward
Jerrold M. Ward National Institutes of Health
Daniel W. Nebert
Daniel W. Nebert University of Cincinnati
Pedro M. Fernandez-Salguero
Pedro M. Fernandez-Salguero University of Extremadura
Harry V. Gelboin
Harry V. Gelboin National Institutes of Health
Leonard D. Kohn
Leonard D. Kohn National Institutes of Health
Parviz Minoo
Parviz Minoo Children's Hospital of Los Angeles
Kunio Nagashima
Kunio Nagashima National Institutes of Health
Raymond P. Donnelly
Raymond P. Donnelly US Food and Drug Administration
Haruhiko Akiyama
Haruhiko Akiyama Gifu University

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