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Charles L. Crespi

D-Index & Metrics

Biology and Biochemistry

D-Index
60
Citations
14128
World Ranking
11876
National Ranking
5103

Charles L. Crespi publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Charles L. Crespi sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 119 publications — 12th percentile

12% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Charles L. Crespi D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Charles L. Crespi sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 60 D-Index — 41st percentile

41% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Charles L. Crespi is a researcher primarily affiliated with Corning (United States). Their research spans several fields within medicine, with a focus on pharmacology and toxicology. The scientist's work notably intersects with oncology, pediatrics, perinatology and child health, and pharmacology.

The scientist's main research topics include drug transport and resistance mechanisms, pharmacological effects and toxicity studies, and pharmacogenetics and drug metabolism. These areas reflect an emphasis on understanding how drugs interact with biological systems, how genetic factors influence drug metabolism, and mechanisms contributing to drug resistance.

Among their recent published works is the paper titled "BindingDB Entry 50004711: Selective inhibition of human cytochrome P450 3A4 by N-[2(R)-hydroxy-1(S)-indanyl]-5-[2(S)-(1,1-dimethylethylaminocarbonyl)-4-[(furo[2,3-b]pyridin-5-yl)methyl]piperazin-1-yl]-4(S)-hydroxy-2(R)-phenylmethylpentanamide and P-glycoprotein by valspodar in gene transfectant systems", published in 2020 in PubMed.

Frequent co-authors collaborating with Charles L. Crespi include:

  • I Kawahara
  • Yukio Kato
  • Hiroaki Suzuki
  • Meguru Achira
  • Kiyomi Ito

Publication venues regularly featuring Crespi's work include:

  • PubMed

Charles L. Crespi's research reflects a comprehensive approach to studying critical aspects of pharmacology and medicine, focusing on how drugs are metabolized and how resistance mechanisms develop. Their published work contributes to the scientific understanding relevant to both clinical and pharmacological fields.

Best Publications

  • DNA damage and mutation in human cells exposed to nitric oxide in vitro.

    T Nguyen;D Brunson;C L Crespi;B W Penman

  • Human cell mutagenicity of oxygenated, nitrated and unsubstituted polycyclic aromatic hydrocarbons associated with urban aerosols.

    John L. Durant;William F. Busby;Arthur L. Lafleur;Bruce W. Penman

  • Differential Activation of Cyclophosphamide and Ifosphamide by Cytochromes P-450 2B and 3A in Human Liver Microsomes

    Thomas K. H. Chang;Georg F. Weber;Charles L. Crespi;David J. Waxman

  • Microtiter plate assays for inhibition of human, drug-metabolizing cytochromes P450

    Charles L. Crespi;Vaughn P. Miller;Bruce W. Penman

  • CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: evidence for an allelic variant with altered catalytic activity.

    Fumihiro Sata;Andrea Sapone;Guillermo Elizondo;Penny Stocker

  • Development of a Substrate-Activity Based Approach To Identify the Major Human Liver P-450 Catalysts of Cyclophosphamide and Ifosfamide Activation Based on cDNA-Expressed Activities and Liver Microsomal P-450 Profiles

    Partha Roy;Li J. Yu;Charles L. Crespi;David J. Waxman

  • The R144C change in the CYP2C9*2 allele alters interaction of the cytochrome P450 with NADPH : cytochrome P450 oxidoreductase

    Charles L. Crespi;Vaughn P. Miller

  • Effect of methanol, ethanol, dimethyl sulfoxide, and acetonitrile on in vitro activities of cDNA-expressed human cytochromes P-450

    William F. Busby;Joseph M. Ackermann;Charles L. Crespi

  • Human Cytochrome P4502B6. Interindividual hepatic expression, substrate specificity, and role in procarcinogen activation

    Erin L. Code;Charles L. Crespi;Bruce W. Penman;Frank J. Gonzalez

  • CYP2C8 polymorphisms in Caucasians and their relationship with paclitaxel 6α-hydroxylase activity in human liver microsomes

    Namrata Bahadur;Julian B.S Leathart;Elaine Mutch;Dorothy Steimel-Crespi

  • A tobacco smoke-derived nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, is activated by multiple human cytochrome P450s including the polymorphic human cytochrome P4502D6.

    Charles L. Crespi;Bruce W. Penman;Harry V. Gelboin;Frank J. Gonzalez

  • Substrate-dependent modulation of CYP3A4 catalytic activity: analysis of 27 test compounds with four fluorometric substrates.

    David M. Stresser;Andrew P. Blanchard;Stephanie D. Turner;John C. L. Erve

  • A novel design of artificial membrane for improving the PAMPA model.

    Xiaoxi Chen;Anthony Murawski;Karishma Patel;Charles L. Crespi

  • Comparison between cytochrome P450 (CYP) content and relative activity approaches to scaling from cDNA-expressed CYPs to human liver microsomes: ratios of accessory proteins as sources of discrepancies between the approaches.

    Karthik Venkatakrishnan;Lisa L. von Moltke;Michael H. Court;Jerold S. Harmatz

  • The role of 12 cDNA-expressed human, rodent, and rabbit cytochromes P450 in the metabolism of benzo[a]pyrene and benzo[a]pyrene trans-7,8-dihydrodiol.

    Magang Shou;Kenneth R. Korzekwa;Charles L Crespi;Frank J. Gonzalez

  • Human cytochrome P450IIA3: cDNA sequence role of the enzyme in the metabolic of promutagens comparison to nitrosamine activation by human cytochrome P450IIE1

    Charles L. Crespi;Bruce W. Penman;Julian A.E. Leakey;Michael P. Arlotto

  • Metabolism: a bottleneck in in vitro toxicological test development. The report and recommendations of ECVAM workshop 54.

    Sandra Coecke;Hans Ahr;Bas J. Blaauboer;Susanne Bremer

  • cDNA-expressed human cytochrome P450s: a new age of molecular toxicology and human risk assessment

    Frank J. Gonzalez;Charles L. Crespi;Harry V. Gelboin

  • A metabolically competent human cell line expressing five cDNAs encoding procarcinogen-activating enzymes : application to mutagenicity testing

    Charles L. Crespi;Frank J. Gonzalez;Dorothy T. Steimel;Thomas R. Turner

  • The development of a human cell line stably expressing human CYP3A4: role in the metabolic activation of aflatoxin B1 and comparison to CYP1A2 and CYP2A3.

    Charles L. Crespi;Bruce W. Penman;Dorothy T. Steimel;Harry V. Gelboin

Frequent Co-Authors

Frank J. Gonzalez
Frank J. Gonzalez National Institutes of Health
William G. Thilly
William G. Thilly MIT
Harry V. Gelboin
Harry V. Gelboin National Institutes of Health
David J. Waxman
David J. Waxman Boston University
Robert Langenbach
Robert Langenbach National Institutes of Health
Glen R. Cass
Glen R. Cass California Institute of Technology
Ann K. Daly
Ann K. Daly Newcastle University
Michael A. Marletta
Michael A. Marletta University of California, Berkeley
Michael P. Hannigan
Michael P. Hannigan University of Colorado Boulder
Harold F. Hemond
Harold F. Hemond MIT

External Links

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Best Scientists Citing Charles L. Crespi

F. Peter Guengerich

F. Peter Guengerich

Vanderbilt University

Publications: 46

Frank J. Gonzalez

Frank J. Gonzalez

National Institutes of Health

Publications: 45

Ann K. Daly

Ann K. Daly

Newcastle University

Publications: 44

Somsak Ruchirawat

Somsak Ruchirawat

Chulabhorn Research Institute

Publications: 39

Jos H. Beijnen

Jos H. Beijnen

Utrecht University

Publications: 37

David J. Waxman

David J. Waxman

Boston University

Publications: 35

David J. Greenblatt

David J. Greenblatt

Tufts University

Publications: 34

Rachel F. Tyndale

Rachel F. Tyndale

University of Toronto

Publications: 31

Tetsuya Kamataki

Tetsuya Kamataki

Hokkaido University

Publications: 30

Hannu Raunio

Hannu Raunio

University of Eastern Finland

Publications: 30

Jan H.M. Schellens

Jan H.M. Schellens

Utrecht University

Publications: 29

Magnus Ingelman-Sundberg

Magnus Ingelman-Sundberg

Karolinska Institute

Publications: 29

Ulrich M. Zanger

Ulrich M. Zanger

Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology

Publications: 27

Lisa L. von Moltke

Lisa L. von Moltke

Tufts University

Publications: 26

Olavi Pelkonen

Olavi Pelkonen

University of Oulu

Publications: 26

Hans H. Maurer

Hans H. Maurer

Saarland University

Publications: 26

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