What is he best known for?
The fields of study he is best known for:
His main research concerns Biochemistry, Cytochrome P450, Microsome, Enzyme and Isozyme.
Charles L. Crespi combines subjects such as Cell culture and Molecular biology with his study of Biochemistry.
His study ties his expertise on Drug metabolism together with the subject of Cytochrome P450.
The study incorporates disciplines such as Methanol, Phenacetin and Hep G2 in addition to Microsome.
His work deals with themes such as Complementary DNA and In vitro, which intersect with Enzyme.
Charles L. Crespi focuses mostly in the field of Isozyme, narrowing it down to matters related to Stereochemistry and, in some cases, CYP3A.
His most cited work include:
- Human cell mutagenicity of oxygenated, nitrated and unsubstituted polycyclic aromatic hydrocarbons associated with urban aerosols (539 citations)
- Differential Activation of Cyclophosphamide and Ifosphamide by Cytochromes P-450 2B and 3A in Human Liver Microsomes (496 citations)
- Microtiter plate assays for inhibition of human, drug-metabolizing cytochromes P450 (391 citations)
What are the main themes of his work throughout his whole career to date?
His scientific interests lie mostly in Biochemistry, Cytochrome P450, Enzyme, Microsome and Cell culture.
All of his Biochemistry and CYP1A2, Transfection, Drug metabolism, Metabolism and Complementary DNA investigations are sub-components of the entire Biochemistry study.
His Cytochrome P450 research is multidisciplinary, relying on both Cytochrome, In vitro, Epoxide hydrolase and Isozyme.
His work on CYP2B6 and Enzyme assay as part of general Enzyme study is frequently connected to Aflatoxin, therefore bridging the gap between diverse disciplines of science and establishing a new relationship between them.
His Microsome research integrates issues from Metabolite, Bufuralol, Stereochemistry and Hydroxylation.
His Cell culture study integrates concerns from other disciplines, such as CYP2A6, Carcinogen, Gene mutation, Molecular biology and Microsomal epoxide hydrolase.
He most often published in these fields:
- Biochemistry (50.89%)
- Cytochrome P450 (32.14%)
- Enzyme (27.68%)
What were the highlights of his more recent work (between 2005-2017)?
- Pharmacology (11.61%)
- Biochemistry (50.89%)
- Chromatography (12.50%)
In recent papers he was focusing on the following fields of study:
Charles L. Crespi mainly focuses on Pharmacology, Biochemistry, Chromatography, CYP1A2 and Microsome.
He interconnects Metabolite and Transporter in the investigation of issues within Pharmacology.
His Biochemistry study frequently draws connections between related disciplines such as Function.
His CYP1A2 research focuses on subjects like CYP3A4, which are linked to CYP2C9, Phenacetin and Quinidine.
His Microsome study combines topics from a wide range of disciplines, such as Cytochrome P450 and Metabolism.
The Cytochrome P450 study combines topics in areas such as High-performance liquid chromatography, Methanol and Hydroxylation.
Between 2005 and 2017, his most popular works were:
- A novel design of artificial membrane for improving the PAMPA model. (110 citations)
- Fluorometric high-throughput screening for inhibitors of cytochrome P450. (82 citations)
- Validation of cytochrome P450 time-dependent inhibition assays: a two-time point IC50 shift approach facilitates kinact assay design (71 citations)
In his most recent research, the most cited papers focused on:
The scientist’s investigation covers issues in Pharmacology, CYP3A4, CYP1A2, CYP2C9 and CYP2D6.
His Pharmacology study combines topics in areas such as Efflux, ATPase and Transporter, ATP-binding cassette transporter.
His research on Enzyme and Cytochrome P450 is centered around CYP3A4.
The concepts of his CYP1A2 study are interwoven with issues in Phenacetin, Sulfaphenazole, Western blot and Stereochemistry.
CYP2C9 is the subject of his research, which falls under Biochemistry.
His CYP2D6 research is multidisciplinary, incorporating perspectives in Metabolite, Inducer and CYP2C19.
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