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Biology and Biochemistry

D-Index
60
Citations
14128
World Ranking
11876
National Ranking
5103

Overview

Charles L. Crespi is a researcher primarily affiliated with Corning (United States). Their research spans several fields within medicine, with a focus on pharmacology and toxicology. The scientist's work notably intersects with oncology, pediatrics, perinatology and child health, and pharmacology.

The scientist's main research topics include drug transport and resistance mechanisms, pharmacological effects and toxicity studies, and pharmacogenetics and drug metabolism. These areas reflect an emphasis on understanding how drugs interact with biological systems, how genetic factors influence drug metabolism, and mechanisms contributing to drug resistance.

Among their recent published works is the paper titled "BindingDB Entry 50004711: Selective inhibition of human cytochrome P450 3A4 by N-[2(R)-hydroxy-1(S)-indanyl]-5-[2(S)-(1,1-dimethylethylaminocarbonyl)-4-[(furo[2,3-b]pyridin-5-yl)methyl]piperazin-1-yl]-4(S)-hydroxy-2(R)-phenylmethylpentanamide and P-glycoprotein by valspodar in gene transfectant systems", published in 2020 in PubMed.

Frequent co-authors collaborating with Charles L. Crespi include:

  • I Kawahara
  • Yukio Kato
  • Hiroaki Suzuki
  • Meguru Achira
  • Kiyomi Ito

Publication venues regularly featuring Crespi's work include:

  • PubMed

Charles L. Crespi's research reflects a comprehensive approach to studying critical aspects of pharmacology and medicine, focusing on how drugs are metabolized and how resistance mechanisms develop. Their published work contributes to the scientific understanding relevant to both clinical and pharmacological fields.

Best Publications

  • DNA damage and mutation in human cells exposed to nitric oxide in vitro.

    T Nguyen;D Brunson;C L Crespi;B W Penman

  • Human cell mutagenicity of oxygenated, nitrated and unsubstituted polycyclic aromatic hydrocarbons associated with urban aerosols.

    John L. Durant;William F. Busby;Arthur L. Lafleur;Bruce W. Penman

  • Differential Activation of Cyclophosphamide and Ifosphamide by Cytochromes P-450 2B and 3A in Human Liver Microsomes

    Thomas K. H. Chang;Georg F. Weber;Charles L. Crespi;David J. Waxman

  • Microtiter plate assays for inhibition of human, drug-metabolizing cytochromes P450

    Charles L. Crespi;Vaughn P. Miller;Bruce W. Penman

  • CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: evidence for an allelic variant with altered catalytic activity.

    Fumihiro Sata;Andrea Sapone;Guillermo Elizondo;Penny Stocker

  • Development of a Substrate-Activity Based Approach To Identify the Major Human Liver P-450 Catalysts of Cyclophosphamide and Ifosfamide Activation Based on cDNA-Expressed Activities and Liver Microsomal P-450 Profiles

    Partha Roy;Li J. Yu;Charles L. Crespi;David J. Waxman

  • The R144C change in the CYP2C9*2 allele alters interaction of the cytochrome P450 with NADPH : cytochrome P450 oxidoreductase

    Charles L. Crespi;Vaughn P. Miller

  • Effect of methanol, ethanol, dimethyl sulfoxide, and acetonitrile on in vitro activities of cDNA-expressed human cytochromes P-450

    William F. Busby;Joseph M. Ackermann;Charles L. Crespi

  • Human Cytochrome P4502B6. Interindividual hepatic expression, substrate specificity, and role in procarcinogen activation

    Erin L. Code;Charles L. Crespi;Bruce W. Penman;Frank J. Gonzalez

  • CYP2C8 polymorphisms in Caucasians and their relationship with paclitaxel 6α-hydroxylase activity in human liver microsomes

    Namrata Bahadur;Julian B.S Leathart;Elaine Mutch;Dorothy Steimel-Crespi

  • A tobacco smoke-derived nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, is activated by multiple human cytochrome P450s including the polymorphic human cytochrome P4502D6.

    Charles L. Crespi;Bruce W. Penman;Harry V. Gelboin;Frank J. Gonzalez

  • Substrate-dependent modulation of CYP3A4 catalytic activity: analysis of 27 test compounds with four fluorometric substrates.

    David M. Stresser;Andrew P. Blanchard;Stephanie D. Turner;John C. L. Erve

  • A novel design of artificial membrane for improving the PAMPA model.

    Xiaoxi Chen;Anthony Murawski;Karishma Patel;Charles L. Crespi

  • Comparison between cytochrome P450 (CYP) content and relative activity approaches to scaling from cDNA-expressed CYPs to human liver microsomes: ratios of accessory proteins as sources of discrepancies between the approaches.

    Karthik Venkatakrishnan;Lisa L. von Moltke;Michael H. Court;Jerold S. Harmatz

  • The role of 12 cDNA-expressed human, rodent, and rabbit cytochromes P450 in the metabolism of benzo[a]pyrene and benzo[a]pyrene trans-7,8-dihydrodiol.

    Magang Shou;Kenneth R. Korzekwa;Charles L Crespi;Frank J. Gonzalez

  • Human cytochrome P450IIA3: cDNA sequence role of the enzyme in the metabolic of promutagens comparison to nitrosamine activation by human cytochrome P450IIE1

    Charles L. Crespi;Bruce W. Penman;Julian A.E. Leakey;Michael P. Arlotto

  • Metabolism: a bottleneck in in vitro toxicological test development. The report and recommendations of ECVAM workshop 54.

    Sandra Coecke;Hans Ahr;Bas J. Blaauboer;Susanne Bremer

  • cDNA-expressed human cytochrome P450s: a new age of molecular toxicology and human risk assessment

    Frank J. Gonzalez;Charles L. Crespi;Harry V. Gelboin

  • A metabolically competent human cell line expressing five cDNAs encoding procarcinogen-activating enzymes : application to mutagenicity testing

    Charles L. Crespi;Frank J. Gonzalez;Dorothy T. Steimel;Thomas R. Turner

  • The development of a human cell line stably expressing human CYP3A4: role in the metabolic activation of aflatoxin B1 and comparison to CYP1A2 and CYP2A3.

    Charles L. Crespi;Bruce W. Penman;Dorothy T. Steimel;Harry V. Gelboin

Frequent Co-Authors

Frank J. Gonzalez
Frank J. Gonzalez National Institutes of Health
Harry V. Gelboin
Harry V. Gelboin National Institutes of Health
David J. Waxman
David J. Waxman Boston University
Robert Langenbach
Robert Langenbach National Institutes of Health
Glen R. Cass
Glen R. Cass California Institute of Technology
Ann K. Daly
Ann K. Daly Newcastle University
Michael A. Marletta
Michael A. Marletta University of California, Berkeley
Michael P. Hannigan
Michael P. Hannigan University of Colorado Boulder

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