World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
60
Citations
16739
World Ranking
11772
National Ranking
5062

Overview

Robert Langenbach is affiliated with the National Institutes of Health in the United States. Their research primarily focuses on the field of Medicine, with specific contributions to Pharmacology, Neurology, Immunology, Genetics, and Endocrinology, Diabetes, and Metabolism.

The scientist's most frequent publication venue is UNC Libraries, where they have contributed four papers. Their work encompasses several key topics within biomedical science, notably inflammatory mediators and NSAID effects, neuroinflammation and neurodegeneration mechanisms, immune response and inflammation, estrogen and related hormone effects, hormonal regulation and hypertension, Helicobacter pylori-related gastroenterology studies, and cytokine signaling pathways and interactions.

Robert Langenbach has co-authored work with multiple researchers, including Scott G. Morham, Oliver Smithies, Dan Zhang, Xiaoming Hu, and Qian Li. These collaborations highlight a network within biomedical research communities.

Their recent papers include the following:

  • Malignant Transformation and Antineoplastic Actions of Nonsteroidal Antiinflammatory Drugs (Nsaids) on Cyclooxygenase-Null Embryo Fibroblasts, 2021, UNC Libraries
  • Prostaglandin E2 released from activated microglia enhances astrocyte proliferation in vitro, 2020, UNC Libraries
  • Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2, 2020, UNC Libraries
  • Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration, 2021, UNC Libraries

These publications illustrate the breadth of their investigation into the molecular and cellular mechanisms underlying inflammation, gastrointestinal injury, and neural proliferation.

Best Publications

  • Multiple female reproductive failures in cyclooxygenase 2-deficient mice.

    Hyunjung Lim;Bibhash C Paria;Sanjoy K Das;Joseph E Dinchuk

  • Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration.

    Robert Langenbach;Scott G. Morham;Howard F. Tiano;Charles D. Loftin

  • Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse

    Scott G. Morham;Robert Langenbach;Charles D. Loftin;Howard F. Tiano

  • Why there are two cyclooxygenase isozymes.

    William L. Smith;Robert Langenbach

  • Genetic disruption of Ptgs-1, as well as of Ptgs-2, reduces intestinal tumorigenesis in Min mice

    Patricia C. Chulada;Morrow B. Thompson;Joel F. Mahler;Christine M. Doyle

  • Anovulation in cyclooxygenase-2-deficient mice is restored by prostaglandin E2 and interleukin-1beta.

    Barbara J. Davis;David E. Lennard;Christopher A. Lee;Howard F. Tiano

  • Deficiency of Either Cyclooxygenase (COX)-1 or COX-2 Alters Epidermal Differentiation and Reduces Mouse Skin Tumorigenesis

    Howard F. Tiano;Charles D. Loftin;Jackie Akunda;Christopher A. Lee

  • Mutagenesis by chemical agents in V79 chinese hamster cells: a review and analysis of the literature. A report of the Gene-Tox Program

    Matthews O. Bradley;Bijoy Bhuyan;Mary C. Francis;Robert Langenbach

  • Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2

    Olivier Morteau;Scott G. Morham;Rance Sellon;Rance Sellon;Levinus A. Dieleman

  • Malignant Transformation and Antineoplastic Actions of Nonsteroidal Antiinflammatory Drugs (Nsaids) on Cyclooxygenase-Null Embryo Fibroblasts

    Xinping Zhang;Scott G. Morham;Robert Langenbach;Donald A. Young

  • Opposite effects of cyclooxygenase-1 and -2 activity on the pressor response to angiotensin II.

    Zhonghua Qi;Chuan-Ming Hao;Robert I. Langenbach;Richard M. Breyer

  • Role of reactive oxygen species in LPS-induced production of prostaglandin E2 in microglia.

    Tongguang Wang;Liya Qin;Bin Liu;Yuxin Liu

  • Allergic lung responses are increased in prostaglandin H synthase–deficient mice

    Stephen H. Gavett;Sharon L. Madison;Patricia C. Chulada;Paula E. Scarborough

  • Cyclooxygenase knockout mice: Models for elucidating isoform-specific functions

    Robert Langenbach;Charles Loftin;Christopher Lee;Howard Tiano

  • Failure of ductus arteriosus closure and remodeling in neonatal mice deficient in cyclooxygenase-1 and cyclooxygenase-2

    Charles D. Loftin;Darshini B. Trivedi;Howard F. Tiano;James A. Clark

  • Cyclooxygenase-2-deficient mice are resistant to 1-methyl-4-phenyl1, 2, 3, 6-tetrahydropyridine-induced damage of dopaminergic neurons in the substantia nigra

    Z.-H Feng;T.-G Wang;D.-D Li;P Fung

  • Human cytochrome P450IIA3: cDNA sequence role of the enzyme in the metabolic of promutagens comparison to nitrosamine activation by human cytochrome P450IIE1

    Charles L. Crespi;Bruce W. Penman;Julian A.E. Leakey;Michael P. Arlotto

  • Cyclooxygenase-deficient mice. A summary of their characteristics and susceptibilities to inflammation and carcinogenesis.

    Robert Langenbach;Charles D. Loftin;Christopher Lee;Howard Tiano

  • Genetic deletion or pharmacological inhibition of cyclooxygenase-1 attenuate lipopolysaccharide-induced inflammatory response and brain injury

    Sang-Ho Choi;Robert Langenbach;Francesca Bosetti

  • A metabolically competent human cell line expressing five cDNAs encoding procarcinogen-activating enzymes : application to mutagenicity testing

    Charles L. Crespi;Frank J. Gonzalez;Dorothy T. Steimel;Thomas R. Turner

Frequent Co-Authors

Darryl C. Zeldin
Darryl C. Zeldin National Institutes of Health
Charles L. Crespi
Charles L. Crespi Corning (United States)
Oliver Smithies
Oliver Smithies University of North Carolina at Chapel Hill
Jau-Shyong Hong
Jau-Shyong Hong National Institutes of Health
James C. Bonner
James C. Bonner North Carolina State University
Dori R. Germolec
Dori R. Germolec National Institutes of Health
Frank J. Gonzalez
Frank J. Gonzalez National Institutes of Health
Belinda Wilson
Belinda Wilson National Institutes of Health
Thomas E. Eling
Thomas E. Eling National Institutes of Health
Richard M. Breyer
Richard M. Breyer Vanderbilt University Medical Center

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