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Medicine

D-Index
113
Citations
53864
World Ranking
4898
National Ranking
2653

Overview

Jau-Shyong Hong is affiliated with the National Institutes of Health in the United States. Their research primarily focuses on neuroscience and medicine, with a particular emphasis on several interconnected subfields including neurology, physiology, immunology, cellular and molecular neuroscience, and molecular biology.

The main topics addressed in Hong's work encompass neuroinflammation and neurodegeneration mechanisms, neurological disease mechanisms and treatments, tryptophan and brain disorders, Alzheimer's disease research and treatments, Parkinson's disease mechanisms and treatments, nuclear receptors and signaling, as well as adenosine and purinergic signaling.

Hong's recent notable publications include:

  • Microglial activation contributes to cognitive impairments in rotenone-induced mouse Parkinson's disease model, 2021, Journal of Neuroinflammation
  • A novel role of NLRP3-generated IL-1β in the acute-chronic transition of peripheral lipopolysaccharide-elicited neuroinflammation: implications for sepsis-associated neurodegeneration, 2020, Journal of Neuroinflammation
  • Locus coeruleus neurons are most sensitive to chronic neuroinflammation-induced neurodegeneration, 2020, Brain Behavior and Immunity
  • Microglial Nox2 Plays a Key Role in the Pathogenesis of Experimental Autoimmune Encephalomyelitis, 2021, Frontiers in Immunology
  • Nicotinamide Adenine Dinucleotide Phosphate Oxidase and Neurodegenerative Diseases: Mechanisms and Therapy, 2020, Antioxidants and Redox Signaling

Frequent collaborators in Hong's research include:

  • Qingshan Wang
  • Belinda Wilson
  • Liyan Hou
  • Sheng Song
  • Jie Zhao

Hong's work has been published repeatedly in several key venues, including:

  • UNC Libraries
  • Free Radical Biology and Medicine
  • Journal of Neuroinflammation
  • SSRN Electronic Journal
  • The International Journal of Neuropsychopharmacology

Best Publications

  • Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

    Michelle L. Block;Luigi Zecca;Jau Shyong Hong

  • Systemic LPS Causes Chronic Neuroinflammation and Progressive Neurodegeneration

    Liya Qin;Xuefei Wu;Michelle L. Block;Yuxin Liu;Yuxin Liu

  • Microglia and inflammation-mediated neurodegeneration: Multiple triggers with a common mechanism

    Michelle L. Block;Jau Shyong Hong

  • Aggregated α-synuclein activates microglia: a process leading to disease progression in Parkinson’s disease

    Wei Zhang;Tongguang Wang;Zhong Pei;David S. Miller

  • Role of Microglia in Inflammation-Mediated Neurodegenerative Diseases: Mechanisms and Strategies for Therapeutic Intervention

    Bin Liu;Jau-Shyong Hong

  • Regional Difference in Susceptibility to Lipopolysaccharide-Induced Neurotoxicity in the Rat Brain: Role of Microglia

    Won-Gon Kim;Robert P. Mohney;Belinda Wilson;Gwang-Ho Jeohn

  • Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression

    Hui Ming Gao;Jau Shyong Hong

  • Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease

    Hui-Ming Gao;Janwei Jiang;Belinda Wilson;Wanqin Zhang

  • NADPH Oxidase Mediates Lipopolysaccharide-induced Neurotoxicity and Proinflammatory Gene Expression in Activated Microglia

    Liya Qin;Yuxin Liu;Tongguang Wang;Sung Jen Wei

  • Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action.

    Hyeon Ju Kim;Michael Rowe;Ming Ren;Jau-Shyong Hong

  • Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatment

    Liya Qin;Jun He;Richard N. Hanes;Olivera Pluzarev

  • Role of nitric oxide in inflammation-mediated neurodegeneration.

    Bin Liu;Hui-Ming Gao;Jiz-Yuh Wang;Gwang-Ho Jeohn

  • Distinct Role for Microglia in Rotenone-Induced Degeneration of Dopaminergic Neurons

    Hui-Ming Gao;Jau-Shyong Hong;Wanqin Zhang;Bin Liu

  • Naloxone Protects Rat Dopaminergic Neurons against Inflammatory Damage through Inhibition of Microglia Activation and Superoxide Generation

    Bin Liu;Lina Du;Jau-Shyong Hong

  • Role of oxidative stress in epileptic seizures

    Eun Joo Shin;Ji Hoon Jeong;Yoon Hee Chung;Won Ki Kim

  • HMGB1 Acts on Microglia Mac1 to Mediate Chronic Neuroinflammation That Drives Progressive Neurodegeneration

    Hui-Ming Gao;Hui Zhou;Feng Zhang;Belinda C. Wilson

  • Nanometer size diesel exhaust particles are selectively toxic to dopaminergic neurons: the role of microglia, phagocytosis, and NADPH oxidase

    M. L. Block;X. Wu;X. Wu;Z. Pei;G. Li

  • Valproate protects dopaminergic neurons in midbrain neuron/glia cultures by stimulating the release of neurotrophic factors from astrocytes

    Po-See Chen;G. S. Peng;G. S. Peng;G. Li;S. Yang

  • Chronic microglial activation and progressive dopaminergic neurotoxicity

    M.L. Block;M.L. Block;J.-S. Hong

  • Neuroinflammation and α-synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of Parkinson's disease.

    Hui-Ming Gao;Feng Zhang;Hui Zhou;Wayneho Kam

Frequent Co-Authors

Belinda Wilson
Belinda Wilson National Institutes of Health
Po See Chen
Po See Chen National Cheng Kung University
Michelle L. Block
Michelle L. Block Indiana University – Purdue University Indianapolis
Yen Kuang Yang
Yen Kuang Yang National Cheng Kung University
Michael K. McMillian
Michael K. McMillian Johnson & Johnson (United States)
Erminio Costa
Erminio Costa National Institutes of Health
Guoying Bing
Guoying Bing University of Kentucky
Jacqueline F. McGinty
Jacqueline F. McGinty Medical University of South Carolina
Syed F. Ali
Syed F. Ali National Center for Toxicological Research
Michal K. Stachowiak
Michal K. Stachowiak University at Buffalo, State University of New York

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