D-Index & Metrics Best Publications
Matthew D. Breyer

Matthew D. Breyer

Eli Lilly (United States)
United States

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Internal medicine
  • Enzyme

Matthew D. Breyer spends much of his time researching Internal medicine, Endocrinology, Receptor, Renal function and Cyclooxygenase. Kidney, Prostaglandin E, Renal physiology, Kidney disease and Macula densa are subfields of Internal medicine in which his conducts study. His Macula densa research includes themes of Renal glomerulus and Renal cortex.

His research integrates issues of Peroxisome proliferator-activated receptor and Nephrology in his study of Endocrinology. His work on Prostaglandin E2 receptor as part of general Receptor research is frequently linked to Class C GPCR, bridging the gap between disciplines. His Renal function study integrates concerns from other disciplines, such as Nitric oxide synthase, Glomerular basement membrane, Inulin and Streptozotocin.

His most cited work include:

  • Prostanoid receptors: subtypes and signaling. (852 citations)
  • Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction. (794 citations)
  • Mouse Models of Diabetic Nephropathy (718 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of investigation include Internal medicine, Endocrinology, Kidney, Receptor and Diabetic nephropathy. His Internal medicine research integrates issues from Gene expression and Eicosanoid. As a member of one scientific family, Matthew D. Breyer mostly works in the field of Endocrinology, focusing on Cyclooxygenase and, on occasion, Renal cortex.

His Kidney research incorporates elements of Renin–angiotensin system, Macula densa, Pharmacology and In situ hybridization. His Receptor research incorporates themes from Molecular biology and Signal transduction. Matthew D. Breyer interconnects Nephropathy, Disease, Immunology and Glomerular basement membrane in the investigation of issues within Diabetic nephropathy.

He most often published in these fields:

  • Internal medicine (75.82%)
  • Endocrinology (72.53%)
  • Kidney (32.97%)

What were the highlights of his more recent work (between 2010-2021)?

  • Internal medicine (75.82%)
  • Kidney disease (14.84%)
  • Albuminuria (13.19%)

In recent papers he was focusing on the following fields of study:

His scientific interests lie mostly in Internal medicine, Kidney disease, Albuminuria, Disease and Diabetic nephropathy. His work on Internal medicine is being expanded to include thematically relevant topics such as Endocrinology. His study in the fields of Kidney and Prostaglandin E2 under the domain of Endocrinology overlaps with other disciplines such as Mean arterial pressure.

His Kidney disease study incorporates themes from Patient satisfaction, Nephrology, Clinical trial, Oncology and Immunology. Matthew D. Breyer works mostly in the field of Disease, limiting it down to concerns involving Diabetic kidney and, occasionally, Creatinine, Nephron and TGF alpha. His Diabetic nephropathy research is multidisciplinary, incorporating perspectives in Disease pathogenesis, Therapeutic trial, Oxidative injury and Intensive care medicine.

Between 2010 and 2021, his most popular works were:

  • The next generation of therapeutics for chronic kidney disease (120 citations)
  • Circulating αKlotho influences phosphate handling by controlling FGF23 production. (117 citations)
  • Prostaglandin E2-Mediated Attenuation of Mesocortical Dopaminergic Pathway Is Critical for Susceptibility to Repeated Social Defeat Stress in Mice (82 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • Internal medicine

His primary areas of study are Internal medicine, Diabetic nephropathy, Kidney disease, Endocrinology and Disease. Many of his research projects under Internal medicine are closely connected to Public attention, Redress and Osteomalacia with Public attention, Redress and Osteomalacia, tying the diverse disciplines of science together. His work carried out in the field of Diabetic nephropathy brings together such families of science as Pathology, Albuminuria, Renal function and Type 2 diabetes.

His Kidney disease study combines topics in areas such as Patient satisfaction, Nephrology and Clinical trial. Endocrinology is often connected to Prostaglandin E2 receptor in his work. His research investigates the connection between Disease and topics such as Fibrosis that intersect with problems in Inflammation.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Prostanoid receptors: subtypes and signaling.

Richard M Breyer;Carey K Bagdassarian;Scott A Myers;Matthew D Breyer.
Annual Review of Pharmacology and Toxicology (2001)

1177 Citations

Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction.

Raymond C. Harris;James A. McKanna;Yoichi Akai;Harry R. Jacobson.
Journal of Clinical Investigation (1994)

1059 Citations

Mouse Models of Diabetic Nephropathy

Frank C. Brosius;Charles E. Alpers;Erwin P. Bottinger;Matthew D. Breyer.
Journal of The American Society of Nephrology (2009)

793 Citations

Thiazolidinediones expand body fluid volume through PPARγ stimulation of ENaC-mediated renal salt absorption

You Fei Guan;Chuanming Hao;Dae Ryong Cha;Reena Rao.
Nature Medicine (2005)

690 Citations

Mesangial cell, glomerular and renal vascular responses to endothelin in the rat kidney. Elucidation of signal transduction pathways.

K F Badr;J J Murray;M D Breyer;K Takahashi.
Journal of Clinical Investigation (1989)

570 Citations

Peroxisome proliferator-activated receptors (PPARs): Novel therapeutic targets in renal disease

YouFei Guan;Matthew D. Breyer.
Kidney International (2001)

466 Citations

SALT-SENSITIVE HYPERTENSION AND REDUCED FERTILITY IN MICE LACKING THE PROSTAGLANDIN EP2 RECEPTOR

Christopher R.J. Kennedy;Yahua Zhang;Suzanne Brandon;Youfei Guan.
Nature Medicine (1999)

458 Citations

Physiological regulation of cyclooxygenase-2 in the kidney

Raymond C. Harris;Matthew D. Breyer.
American Journal of Physiology-renal Physiology (2001)

375 Citations

Endothelial Nitric Oxide Synthase Deficiency Produces Accelerated Nephropathy in Diabetic Mice

Hui John Zhao;Suwan Wang;Huifang Cheng;Ming-zhi Zhang.
Journal of The American Society of Nephrology (2006)

354 Citations

Serial determination of glomerular filtration rate in conscious mice using FITC-inulin clearance

Zhonghua Qi;Zhonghua Qi;Irene Whitt;Amit Mehta;Jianping Jin.
American Journal of Physiology-renal Physiology (2004)

351 Citations

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