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Chemistry
USA
2026

D-Index & Metrics

Chemistry

D-Index
136
Citations
60473
World Ranking
246
National Ranking
118

Biology and Biochemistry

D-Index
137
Citations
62675
World Ranking
330
National Ranking
222

Medicine

D-Index
136
Citations
61354
World Ranking
1995
National Ranking
1134

Research.com Recognitions

  • 2026 - Research.com Chemistry in United States Leader Award
  • 2025 - Research.com Chemistry in United States Leader Award

Overview

John R. Falck is affiliated with The University of Texas Southwestern Medical Center in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions also in related subfields such as Biochemistry, Endocrinology, Diabetes and Metabolism, Physiology, Organic Chemistry, and Cardiology and Cardiovascular Medicine.

Their research topics focus extensively on Eicosanoids and Hypertension Pharmacology, Hormonal Regulation and Hypertension, and Nitric Oxide and Endothelin Effects. Other topics of interest include Catalytic C-H Functionalization Methods, Asymmetric Hydrogenation and Catalysis, Cancer, Hypoxia, and Metabolism, as well as Blood Pressure and Hypertension Studies.

Falck's recent publications include:

  • Picolinate-Directed Arene meta-C-H Amination via FeCl3 Catalysis, 2020, Journal of the American Chemical Society
  • Uncovering the signalling, structure and function of the 20-HETE-GPR75 pairing: Identifying the chemokine CCL5 as a negative regulator of GPR75, 2021, British Journal of Pharmacology
  • 20-HETE interferes with insulin signaling and contributes to obesity-driven insulin resistance, 2020, Prostaglandins & Other Lipid Mediators
  • 20-HETE Participates in Intracerebral Hemorrhage-Induced Acute Injury by Promoting Cell Ferroptosis, 2021, Frontiers in Neurology
  • Kidney-Targeted Epoxyeicosatrienoic Acid Analog, EET-F01, Reduces Inflammation, Oxidative Stress, and Cisplatin-Induced Nephrotoxicity, 2021, International Journal of Molecular Sciences

Frequent co-authors in Falck's work include:

  • Adeniyi Michael Adebesin
  • Michal L. Schwartzman
  • John D. Imig
  • Jonathan V. Pascale
  • Víctor Garcia

The most common publishing venues for their work are:

  • The FASEB Journal
  • UNC Libraries
  • Journal of the American Chemical Society
  • Prostaglandins & Other Lipid Mediators
  • International Journal of Molecular Sciences

Best Publications

  • An oxysterol signalling pathway mediated by the nuclear receptor LXRα

    Bethany A. Janowski;Patricia J. Willy;Thota Rama Devi;J. R. Falck

  • Role of Substrates and Products of PI 3-kinase in Regulating Activation of Rac-Related Guanosine Triphosphatases by Vav

    Jaewon Han;Katherine Luby-Phelps;Balaka Das;Xiaodong Shu

  • Lysine propionylation and butyrylation are novel post-translational modifications in histones.

    Yue Chen;Robert Sprung;Yi Tang;Haydn Ball

  • Cytochrome P450 and arachidonic acid bioactivation: molecular and functional properties of the arachidonate monooxygenase

    Jorge H. Capdevila;John R. Falck;Raymond C. Harris

  • Targeting QseC Signaling and Virulence for Antibiotic Development

    David A. Rasko;Cristiano G. Moreira;De Run Li;Nicola C. Reading

  • High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity*

    Matthias Frech;Mirjana Andjelkovic;Evan Ingley;K. Kishta Reddy

  • MOLECULAR CLONING AND EXPRESSION OF CYP2J2, A HUMAN CYTOCHROME P450 ARACHIDONIC ACID EPOXYGENASE HIGHLY EXPRESSED IN HEART

    Shu Wu;Cindy R. Moomaw;Kenneth B. Tomer;John R. Falck

  • Human cytochromes P450

    Julia A Hasler;Ronald Estabrook;Michael Murray;Irina Pikuleva

  • Cytochrome P450 and the arachidonate cascade.

    Jorge H. Capdevila;J R Falck;Ronald W. Estabrook

  • Structure-activity analysis of the interaction of curacin A, the potent colchicine site antimitotic agent, with tubulin and effects of analogs on the growth of MCF-7 breast cancer cells.

    Pascal Verdier-Pinard;Jing Yu Lai;Hae Dong Yoo;Jurong Yu

  • A tagging-via-substrate technology for detection and proteomics of farnesylated proteins

    Yoonjung Kho;Sung Chan Kim;Chen Jiang;Deb Barma

  • Production of 20-HETE and Its Role in Autoregulation of Cerebral Blood Flow

    Debebe Gebremedhin;Andrew R. Lange;Timothy F. Lowry;M. Reza Taheri

  • Direct Stereospecific Synthesis of Unprotected N-H and N-Me Aziridines from Olefins

    Jawahar L. Jat;Mahesh P. Paudyal;Hongyin Gao;Qing Long Xu

  • Amide-directed tandem C-C/C-N bond formation through C-H activation.

    Chen Zhu;Rui Wang;John R. Falck

  • Mechanism of action of cerebral epoxyeicosatrienoic acids on cerebral arterial smooth muscle.

    D. Gebremedhin;Y. H. Ma;J. R. Falck;R. J. Roman

  • 20-HETE is an endogenous inhibitor of the large-conductance Ca(2+)-activated K+ channel in renal arterioles

    Ai Ping Zou;John T. Fleming;John R. Falck;Elizabeth R. Jacobs

  • Visualization of acidic organelles in intact cells by electron microscopy

    Richard G. W. Anderson;J. R. Falck;Joseph L. Goldstein;Michael S. Brown

  • Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1

    Metello Innocenti;Emanuela Frittoli;Isabella Ponzanelli;John R. Falck

  • Cytochrome P450-Derived Arachidonic Acid Metabolism in the Rat Kidney: Characterization of Selective Inhibitors

    Mong Heng Wang;Elimor Brand-Schieber;Barbara A. Zand;Xuandai Nguyen

  • Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice

    Dipak Panigrahy;Matthew L. Edin;Craig R. Lee;Craig R. Lee;Sui Huang;Sui Huang

Frequent Co-Authors

Jorge H. Capdevila
Jorge H. Capdevila Vanderbilt University
William B. Campbell
William B. Campbell Medical College of Wisconsin
Charles Mioskowski
Charles Mioskowski Centre national de la recherche scientifique, CNRS
Michal L. Schwartzman
Michal L. Schwartzman New York Medical College
Richard J. Roman
Richard J. Roman University of Mississippi Medical Center
John D. Imig
John D. Imig Medical College of Wisconsin
Darryl C. Zeldin
Darryl C. Zeldin National Institutes of Health
David R. Harder
David R. Harder Medical College of Wisconsin
Bruce D. Hammock
Bruce D. Hammock University of California, Davis
Chen Zhu
Chen Zhu Shanghai Jiao Tong University

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