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D-Index & Metrics

Biology and Biochemistry

D-Index
67
Citations
14476
World Ranking
8297
National Ranking
3750

Overview

Stephen B. Shears is affiliated with the National Institutes of Health in the United States. Their research encompasses biochemistry, genetics, and molecular biology, with additional work in medicine. Subfields of particular focus include molecular biology, cell biology, plant science, physiology, and surgery.

The scientist's work addresses several main topics including:

  • Protein kinase regulation and GTPase signaling
  • Cellular transport and secretion
  • Pancreatic function and diabetes
  • Lysosomal storage disorders research
  • Trace elements in health
  • Endoplasmic reticulum stress and disease
  • Parathyroid disorders and treatments

Frequent coauthors contributing to their research include Huanchen Wang, Henning J. Jessen, Chunfang Gu, Guangning Zong, and Nikolaus Jork.

Stephen B. Shears has published multiple papers in various scientific journals. Notable recent publications include:

  • "Analysis of inositol phosphate metabolism by capillary electrophoresis electrospray ionization mass spectrometry," 2020, Nature Communications
  • "Control of XPR1-dependent cellular phosphate efflux by InsP 8 is an exemplar for functionally-exclusive inositol pyrophosphate signaling," 2020, Proceedings of the National Academy of Sciences
  • "Capillary electrophoresis mass spectrometry identifies new isomers of inositol pyrophosphates in mammalian tissues," 2022, Chemical Science
  • "Metabolic supervision by PPIP5K, an inositol pyrophosphate kinase/phosphatase, controls proliferation of the HCT116 tumor cell line," 2021, Proceedings of the National Academy of Sciences
  • "InsP7 is a small-molecule regulator of NUDT3-mediated mRNA decapping and processing-body dynamics," 2020, Proceedings of the National Academy of Sciences

Publication venues where this scientist frequently appears include bioRxiv (Cold Spring Harbor Laboratory), UNC Libraries, Proceedings of the National Academy of Sciences, The FASEB Journal, and Nature Communications.

Best Publications

  • Essential Role of Phosphoinositide Metabolism in Synaptic Vesicle Recycling

    Ottavio Cremona;Ottavio Cremona;Gilbert Di Paolo;Markus R Wenk;Anita Lüthi

  • A Salmonella inositol polyphosphatase acts in conjunction with other bacterial effectors to promote host cell actin cytoskeleton rearrangements and bacterial internalization.

    Daoguo Zhou;Li-Mei Chen;Lorraine Hernandez;Stephen B. Shears

  • Metabolism of the inositol phosphates produced upon receptor activation.

    S B Shears

  • Stepwise enzymatic dephosphorylation of inositol 1,4,5-trisphosphate to inositol in liver

    Diane J. Storey;Stephen B. Shears;Christopher J. Kirk;Robert H. Michell

  • Turnover of inositol polyphosphate pyrophosphates in pancreatoma cells.

    FS Menniti;RN Miller;Jr Jw Putney;SB Shears

  • Assessing the omnipotence of inositol hexakisphosphate

    Stephen B Shears

  • How versatile are inositol phosphate kinases

    Stephen B Shears

  • Activation of Ca2+ entry into acinar cells by a non-phosphorylatable inositol trisphosphate.

    G. S. J. Bird;M. F. Rossier;A. R. Hughes;S. B. Shears

  • The versatility of inositol phosphates as cellular signals

    Stephen B Shears

  • Inhibition of Clathrin Assembly by High Affinity Binding of Specific Inositol Polyphosphates to the Synapse-specific Clathrin Assembly Protein AP-3

    Weilan Ye;Nawab Ali;Michael E. Bembenek;Stephen B. Shears

  • Long-term uncoupling of chloride secretion from intracellular calcium levels by Ins(3,4,5,6)P4.

    Mana Vajanaphanich;Carsten Schultz;Marco T. Rudolf;Matthew Wasserman

  • The inositol hexakisphosphate kinase family. Catalytic flexibility and function in yeast vacuole biogenesis.

    Adolfo Saiardi;James J. Caffrey;Solomon H. Snyder;Stephen B. Shears

  • Inositol polyphosphate multikinase (ArgRIII) determines nuclear mRNA export in Saccharomyces cerevisiae

    Adolfo Saiardi;James J Caffrey;Solomon H Snyder;Stephen B Shears

  • Diphosphoinositol Polyphosphates: Metabolic Messengers?

    Stephen B. Shears

  • A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase.

    Stephen T. Safrany;James J. Caffrey;Xiaonian Yang;Michael E. Bembenek

  • The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type protein.

    Stephen T. Safrany;Stephen W. Ingram;Jared L. Cartwright;J.R. Falck

  • Inositol phosphates and cell signaling: new views of InsP5 and InsP6.

    Frank S. Menniti;Kerry G. Oliver;James W. Putney;Stephen B. Shears

  • Metabolism of D-myo-inositol 1,3,4,5-tetrakisphosphate by rat liver, including the synthesis of a novel isomer of myo-inositol tetrakisphosphate.

    S. B. Shears;J. B. Parry;E. K. Y. Tang;R. F. Irvine

  • In Saccharomyces cerevisiae, the inositol polyphosphate kinase activity of Kcs1p is required for resistance to salt stress, cell wall integrity, and vacuolar morphogenesis.

    Evelyne Dubois;Bart Scherens;Fabienne Vierendeels;Melisa M.W. Ho

  • Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding.

    Huanchen Wang;J R Falck;Traci M Tanaka Hall;Stephen B Shears

Frequent Co-Authors

Christopher J. Kirk
Christopher J. Kirk Kezar Life Sciences
Barry V. L. Potter
Barry V. L. Potter University of Oxford
Robert H. Michell
Robert H. Michell University of Birmingham
John R. Falck
John R. Falck The University of Texas Southwestern Medical Center
James W. Putney
James W. Putney National Institutes of Health
Per-Olof Berggren
Per-Olof Berggren Karolinska Institute
Adolfo Saiardi
Adolfo Saiardi University College London
Christophe Erneux
Christophe Erneux Université Libre de Bruxelles
Deborah J. Nelson
Deborah J. Nelson University of Chicago
Carsten Schultz
Carsten Schultz Oregon Health & Science University

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