World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
54
Citations
11859
World Ranking
15530
National Ranking
6479

Overview

John D. York is affiliated with Vanderbilt University in the United States. Their research spans the fields of biochemistry, genetics, molecular biology, and medicine, with particular focus on molecular biology, cell biology, surgery, epidemiology, and plant science. York's work encompasses a broad range of topics, including cellular transport and secretion, liver disease diagnosis and treatment, protein kinase regulation and GTPase signaling, protein tyrosine phosphatases, connective tissue disorders research, pancreatic function and diabetes, and Helicobacter pylori-related gastroenterology studies.

York has contributed publications to prominent venues such as Advances in Biological Regulation, Medical Research Archives, Gastroenterology, Journal of Biological Chemistry, and bioRxiv (Cold Spring Harbor Laboratory). Notable papers include:

  • Intestinal Sulfation Is Essential to Protect Against Colitis and Colonic Carcinogenesis (2021, Gastroenterology)
  • Vip1 Is a Kinase and Pyrophosphatase Switch That Regulates Inositol Diphosphate Signaling (2020, Proceedings of the National Academy of Sciences)
  • Inhibition of p53 Sulfoconjugation Prevents Oxidative Hepatotoxicity and Acute Liver Failure (2021, Gastroenterology)
  • Transcriptional Dysregulation Underlies Both Monogenic Arrhythmia Syndrome and Common Modifiers of Cardiac Repolarization (2022, Circulation)
  • A Structural Basis for Lithium and Substrate Binding of an Inositide Phosphatase (2020, Journal of Biological Chemistry)

Frequent collaborators in their research include Zigmund Luka, Andrew T. Hale, Pengfei Xu, Yue Xi, and Meishu Xu.

Best Publications

  • Phosphatidylinositol 4,5-Bisphosphate Functions as a Second Messenger that Regulates Cytoskeleton–Plasma Membrane Adhesion

    Drazen Raucher;Thomas Stauffer;Wen Chen;Kang Shen

  • A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export.

    John D. York;Audrey R. Odom;Robert Murphy;Eric B. Ives

  • Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis

    Roberto J. Botelho;Mary Teruel;Renee Dierckman;Richard Anderson

  • A Role for Nuclear Inositol 1,4,5-Trisphosphate Kinase in Transcriptional Control

    Audrey R. Odom;Alke Stahlberg;Susan R. Wente;John D. York

  • Estrogen-induced activation of mitogen-activated protein kinase requires mobilization of intracellular calcium

    T Improta-Brears;A R Whorton;F Codazzi;J D York

  • SAC1-LIKE DOMAINS OF YEAST SAC1, INP52, AND INP53 AND OF HUMAN SYNAPTOJANIN ENCODE POLYPHOSPHOINOSITIDE PHOSPHATASES

    Shuling Guo;Leslie E. Stolz;Shannon M. Lemrow;John D. York

  • Generation of phytate-free seeds in Arabidopsis through disruption of inositol polyphosphate kinases

    Jill Stevenson-Paulik;Robert J. Bastidas;Shean-Tai Chiou;Roy A. Frye

  • Regulation of a cyclin-CDK-CDK inhibitor complex by inositol pyrophosphates.

    Young-Sam Lee;Sashidhar Mulugu;John D. York;Erin K. O'Shea

  • Structural analyses of Candida albicans sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis.

    Tatiana Y. Hargrove;Laura Friggeri;Zdzislaw Wawrzak;Aidong Qi

  • Tyrosine 1101 of Tie2 Is the Major Site of Association of p85 and Is Required for Activation of Phosphatidylinositol 3-Kinase and Akt

    Christopher D. Kontos;Thomas P. Stauffer;Wen-Pin Yang;John D. York

  • A conserved family of enzymes that phosphorylate inositol hexakisphosphate

    Sashidhar Mulugu;Sashidhar Mulugu;Wenli Bai;Wenli Bai;Peter C. Fridy;Peter C. Fridy;Robert J. Bastidas;Robert J. Bastidas

  • Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1.

    Minxiang Gu;John D. York;Ilka Warshawsky;Philip W. Majerus

  • Intracellular Ph Regulation by Na+/H+ Exchange Requires Phosphatidylinositol 4,5-Bisphosphate

    Orit Aharonovitz;Hans C. Zaun;Tamas Balla;John D. York

  • Definition of a metal-dependent/Li(+)-inhibited phosphomonoesterase protein family based upon a conserved three-dimensional core structure.

    John D. York;Jay W. Ponder;Philip W. Majerus

  • Isolation, characterization, and cDNA cloning of a vampire bat salivary plasminogen activator.

    S J Gardell;L T Duong;R E Diehl;J D York

  • A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells

    Ann M. Winter-Vann;Rudi A. Baron;Waihay Wong;June dela Cruz

  • Roles of inositol phosphates and inositol pyrophosphates in development, cell signaling and nuclear processes.

    Marco M. Tsui;John D. York

  • Regulation of nuclear processes by inositol polyphosphates.

    John D. York

  • SPECIFICITY DETERMINANTS IN PHOSPHOINOSITIDE DEPHOSPHORYLATION: CRYSTAL STRUCTURE OF AN ARCHETYPAL INOSITOL POLYPHOSPHATE 5-PHOSPHATASE

    Yosuke Tsujishita;Shuling Guo;Leslie E. Stolz;John D. York

  • Inositol Diphosphate Signaling Regulates Telomere Length

    Sally J. York;Blaine N. Armbruster;Patricia Greenwell;Thomas D. Petes

Frequent Co-Authors

Philip W. Majerus
Philip W. Majerus Washington University in St. Louis
Tobias Meyer
Tobias Meyer Stanford University
Tamas Balla
Tamas Balla National Institutes of Health
Susan R. Wente
Susan R. Wente Wake Forest University
Jan E. Carette
Jan E. Carette Stanford University
Christian R. H. Raetz
Christian R. H. Raetz Duke University
Stephen B. Shears
Stephen B. Shears National Institutes of Health
Kevin G. Peters
Kevin G. Peters Procter & Gamble (United States)
Robert T. Abraham
Robert T. Abraham Pfizer (United States)
Vytas A. Bankaitis
Vytas A. Bankaitis Texas A&M University

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