D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 102 Citations 49,046 238 World Ranking 930 National Ranking 584

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • Cancer

Robert T. Abraham mainly investigates Cell biology, Phosphorylation, Signal transduction, PI3K/AKT/mTOR pathway and Biochemistry. Robert T. Abraham works in the field of Cell biology, namely Tyrosine phosphorylation. His research integrates issues of Proteasome, K562 cells and DNA damage, Genotoxic Stress in his study of Phosphorylation.

The study incorporates disciplines such as Carcinogenesis, Kinase, Protein kinase A and Effector in addition to Signal transduction. His PI3K/AKT/mTOR pathway research integrates issues from Cancer, FKBP and Function. His RPTOR study combines topics in areas such as TOR Serine-Threonine Kinases, Cancer research, Sirolimus, mTORC2 and P70-S6 Kinase 1.

His most cited work include:

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3242 citations)
  • Cell cycle checkpoint signaling through the ATM and ATR kinases (1718 citations)
  • Inhibition of ATM and ATR Kinase Activities by the Radiosensitizing Agent, Caffeine (1007 citations)

What are the main themes of his work throughout his whole career to date?

Robert T. Abraham mainly focuses on Cell biology, Biochemistry, Signal transduction, PI3K/AKT/mTOR pathway and Kinase. Robert T. Abraham interconnects Jurkat cells, T cell and T-cell receptor in the investigation of issues within Cell biology. His work deals with themes such as Carcinogenesis, Receptor, Intracellular and Effector, which intersect with Signal transduction.

His study in PI3K/AKT/mTOR pathway is interdisciplinary in nature, drawing from both Cancer research and Sirolimus. His biological study spans a wide range of topics, including Cell cycle checkpoint and Small molecule. His study looks at the relationship between Phosphorylation and topics such as DNA damage, which overlap with DNA replication and DNA repair.

He most often published in these fields:

  • Cell biology (51.67%)
  • Biochemistry (27.08%)
  • Signal transduction (24.58%)

What were the highlights of his more recent work (between 2008-2021)?

  • Cell biology (51.67%)
  • Cancer research (17.92%)
  • PI3K/AKT/mTOR pathway (21.67%)

In recent papers he was focusing on the following fields of study:

His main research concerns Cell biology, Cancer research, PI3K/AKT/mTOR pathway, Cancer and Biochemistry. His Cell biology study combines topics from a wide range of disciplines, such as Autophagy, G2-M DNA damage checkpoint and Cell metabolism. His Cancer research research is multidisciplinary, relying on both Antibody-drug conjugate, Immunology, Antigen, Lung cancer and In vivo.

The subject of his PI3K/AKT/mTOR pathway research is within the realm of Signal transduction. His Signal transduction research focuses on Enzyme inhibitor and how it connects with Growth inhibition. His Cancer research includes themes of Antibody and Immune system.

Between 2008 and 2021, his most popular works were:

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3242 citations)
  • The PI3K Pathway in Human Disease (672 citations)
  • Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin. (317 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • Cancer

Robert T. Abraham focuses on Cell biology, PI3K/AKT/mTOR pathway, mTORC1, Autophagy and Cell growth. The concepts of his Cell biology study are interwoven with issues in DNA damage, G2-M DNA damage checkpoint, Cyclin-dependent kinase, Cell cycle and DNA replication. His PI3K/AKT/mTOR pathway research entails a greater understanding of Signal transduction.

His Autophagy study results in a more complete grasp of Biochemistry. P70-S6 Kinase 1, Sirolimus and Everolimus is closely connected to RPTOR in his research, which is encompassed under the umbrella topic of mTORC2. His work in TOR Serine-Threonine Kinases covers topics such as Kinase which are related to areas like In vitro and Structure–activity relationship.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham.
Autophagy (2012)

8302 Citations

Cell cycle checkpoint signaling through the ATM and ATR kinases

Robert T. Abraham.
Genes & Development (2001)

2601 Citations

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

Anne-Claude Gingras;Steven P. Gygi;Brian Raught;Roberto D. Polakiewicz.
Genes & Development (1999)

1489 Citations

Regulation of Hypoxia-Inducible Factor 1α Expression and Function by the Mammalian Target of Rapamycin

Christine C. Hudson;Mei Liu;Gary G. Chiang;Diane M. Otterness.
Molecular and Cellular Biology (2002)

1446 Citations

A role for ATR in the DNA damage-induced phosphorylation of p53

Randal S. Tibbetts;Kathryn M. Brumbaugh;Josie M. Williams;Jann N. Sarkaria.
Genes & Development (1999)

1371 Citations

Inhibition of ATM and ATR Kinase Activities by the Radiosensitizing Agent, Caffeine

Jann N. Sarkaria;Ericka C. Busby;Randal S. Tibbetts;Pia Roos.
Cancer Research (1999)

1319 Citations

Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

Gregory J. Brunn;Christine C. Hudson;Aleksandar Sekulić;Josie M. Williams.
Science (1997)

1099 Citations

Isolation of a Protein Target of the FKBP12-Rapamycin Complex in Mammalian Cells

Candace J. Sabers;Mary M. Martin;Gregory J. Brunn;Josie M. Williams.
Journal of Biological Chemistry (1995)

950 Citations

A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells

Aleksandar Sekulić;Christine C. Hudson;James L. Homme;Peng Yin.
Cancer Research (2000)

924 Citations

Wortmannin, a Potent and Selective Inhibitor of Phosphatidylinositol-3-kinase

G Powis;R Bonjouklian;R Bonjouklian;M M Berggren;M M Berggren;A Gallegos;A Gallegos.
Cancer Research (1994)

854 Citations

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