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D-Index & Metrics

Biology and Biochemistry

D-Index
107
Citations
55057
World Ranking
1081
National Ranking
650

Overview

Robert T. Abraham is affiliated with Pfizer in the United States and has contributed extensively to the fields of biochemistry, genetics, molecular biology, and medicine. Their research primarily focuses on molecular biology, pulmonary and respiratory medicine, pathology and forensic medicine, biomedical engineering, and oncology.

The scientist's work covers several key topics, including:

  • Genetic factors in colorectal cancer
  • Advanced breast cancer therapies
  • Metabolism, diabetes, and cancer
  • DNA repair mechanisms
  • Nuclear structure and function
  • CAR-T cell therapy research
  • Nanowire synthesis and applications

Robert T. Abraham has co-authored multiple studies with frequent collaborators such as Aaron N. Snead, Jason C. Green, Christie L. Eissler, Steffen M. Bernard, and Eileen Tran.

The researcher has published in a variety of scientific journals, with several recurrent venues including:

  • Nature
  • Molecular Cancer Research
  • UNC Libraries
  • Nature Communications
  • Cell Cycle

Among the recent research papers contributed to by Abraham are:

  • Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase (2024, Nature)
  • Direct control of CAR T cells through small molecule-regulated antibodies (2021, Nature Communications)
  • Sustained mTORC1 activity during palbociclib-induced growth arrest triggers senescence in ER+ breast cancer cells (2020, Cell Cycle)
  • Anti-tumor immunity influences cancer cell reliance upon ATG7 (2020, OncoImmunology)
  • Suppression of NRF2-dependent cancer growth by a covalent allosteric molecular glue (2024, bioRxiv, Cold Spring Harbor Laboratory)

Robert T. Abraham's studies intersect fundamental molecular mechanisms with clinical applications, including the modulation of cancer growth pathways and immune system interactions. Their research spans various experimental approaches relevant to cancer biology, drug discovery, and cellular therapies.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Cell cycle checkpoint signaling through the ATM and ATR kinases

    Robert T. Abraham

  • The PI3K pathway in human disease

    David A. Fruman;Honyin Chiu;Benjamin D. Hopkins;Shubha Bagrodia

  • Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

    Anne-Claude Gingras;Steven P. Gygi;Brian Raught;Roberto D. Polakiewicz

  • Regulation of Hypoxia-Inducible Factor 1α Expression and Function by the Mammalian Target of Rapamycin

    Christine C. Hudson;Mei Liu;Gary G. Chiang;Diane M. Otterness

  • A role for ATR in the DNA damage-induced phosphorylation of p53

    Randal S. Tibbetts;Kathryn M. Brumbaugh;Josie M. Williams;Jann N. Sarkaria

  • Inhibition of ATM and ATR Kinase Activities by the Radiosensitizing Agent, Caffeine

    Jann N. Sarkaria;Ericka C. Busby;Randal S. Tibbetts;Pia Roos

  • Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

    Gregory J. Brunn;Christine C. Hudson;Aleksandar Sekulić;Aleksandar Sekulić;Aleksandar Sekulić;Josie M. Williams

  • Isolation of a Protein Target of the FKBP12-Rapamycin Complex in Mammalian Cells

    Candace J. Sabers;Mary M. Martin;Gregory J. Brunn;Josie M. Williams

  • A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells

    Aleksandar Sekulić;Christine C. Hudson;James L. Homme;Peng Yin

  • Wortmannin, a Potent and Selective Inhibitor of Phosphatidylinositol-3-kinase

    G Powis;R Bonjouklian;R Bonjouklian;M M Berggren;M M Berggren;A Gallegos;A Gallegos

  • Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

    G. J. Brunn;J. Williams;C. Sabers;G. Wiederrecht

  • Immunopharmacology of rapamycin.

    Robert T. Abraham;Gregory J. Wiederrecht

  • Jurkat T cells and development of the T-cell receptor signalling paradigm

    Robert T. Abraham;Arthur Weiss

  • Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress.

    Randal S. Tibbetts;David Cortez;Kathryn M. Brumbaugh;Ralph Scully

  • Inhibition of Phosphoinositide 3-Kinase Related Kinases by the Radiosensitizing Agent Wortmannin

    Jann N. Sarkaria;Randal S. Tibbetts;Ericka C. Busby;Amy P. Kennedy

  • Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase.

    Gary G. Chiang;Robert T. Abraham

  • PI 3-kinase related kinases: 'big' players in stress-induced signaling pathways.

    Robert T. Abraham

  • Distinct requirements for Ras oncogenesis in human versus mouse cells

    Nesrin M. Hamad;Joel H. Elconin;Antoine E. Karnoub;Wenli Bai

  • Functional Analysis of Human Microtubule-based Motor Proteins, the Kinesins and Dyneins, in Mitosis/Cytokinesis Using RNA Interference

    Changjun Zhu;Jian Zhao;Marina Bibikova;Joel D. Leverson

Frequent Co-Authors

Paul J. Leibson
Paul J. Leibson Mayo Clinic
Larry M. Karnitz
Larry M. Karnitz Mayo Clinic
Weiguo Zhang
Weiguo Zhang Duke University
Tarek S. Mansour
Tarek S. Mansour Pfizer (United States)
Garth Powis
Garth Powis Sanford Burnham Prebys Medical Discovery Institute
David J. McKean
David J. McKean Mayo Clinic
Jann N. Sarkaria
Jann N. Sarkaria Mayo Clinic
Garth Powis
Garth Powis Discovery Institute
John C. Lawrence
John C. Lawrence University of Virginia
Lawrence E. Samelson
Lawrence E. Samelson National Institutes of Health

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