Robert T. Abraham mainly investigates Cell biology, Phosphorylation, Signal transduction, PI3K/AKT/mTOR pathway and Biochemistry. Robert T. Abraham works in the field of Cell biology, namely Tyrosine phosphorylation. His research integrates issues of Proteasome, K562 cells and DNA damage, Genotoxic Stress in his study of Phosphorylation.
The study incorporates disciplines such as Carcinogenesis, Kinase, Protein kinase A and Effector in addition to Signal transduction. His PI3K/AKT/mTOR pathway research integrates issues from Cancer, FKBP and Function. His RPTOR study combines topics in areas such as TOR Serine-Threonine Kinases, Cancer research, Sirolimus, mTORC2 and P70-S6 Kinase 1.
Robert T. Abraham mainly focuses on Cell biology, Biochemistry, Signal transduction, PI3K/AKT/mTOR pathway and Kinase. Robert T. Abraham interconnects Jurkat cells, T cell and T-cell receptor in the investigation of issues within Cell biology. His work deals with themes such as Carcinogenesis, Receptor, Intracellular and Effector, which intersect with Signal transduction.
His study in PI3K/AKT/mTOR pathway is interdisciplinary in nature, drawing from both Cancer research and Sirolimus. His biological study spans a wide range of topics, including Cell cycle checkpoint and Small molecule. His study looks at the relationship between Phosphorylation and topics such as DNA damage, which overlap with DNA replication and DNA repair.
His main research concerns Cell biology, Cancer research, PI3K/AKT/mTOR pathway, Cancer and Biochemistry. His Cell biology study combines topics from a wide range of disciplines, such as Autophagy, G2-M DNA damage checkpoint and Cell metabolism. His Cancer research research is multidisciplinary, relying on both Antibody-drug conjugate, Immunology, Antigen, Lung cancer and In vivo.
The subject of his PI3K/AKT/mTOR pathway research is within the realm of Signal transduction. His Signal transduction research focuses on Enzyme inhibitor and how it connects with Growth inhibition. His Cancer research includes themes of Antibody and Immune system.
Robert T. Abraham focuses on Cell biology, PI3K/AKT/mTOR pathway, mTORC1, Autophagy and Cell growth. The concepts of his Cell biology study are interwoven with issues in DNA damage, G2-M DNA damage checkpoint, Cyclin-dependent kinase, Cell cycle and DNA replication. His PI3K/AKT/mTOR pathway research entails a greater understanding of Signal transduction.
His Autophagy study results in a more complete grasp of Biochemistry. P70-S6 Kinase 1, Sirolimus and Everolimus is closely connected to RPTOR in his research, which is encompassed under the umbrella topic of mTORC2. His work in TOR Serine-Threonine Kinases covers topics such as Kinase which are related to areas like In vitro and Structure–activity relationship.
Guidelines for the use and interpretation of assays for monitoring autophagy
Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham.
Cell cycle checkpoint signaling through the ATM and ATR kinases
Robert T. Abraham.
Genes & Development (2001)
Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism
Anne-Claude Gingras;Steven P. Gygi;Brian Raught;Roberto D. Polakiewicz.
Genes & Development (1999)
Regulation of Hypoxia-Inducible Factor 1α Expression and Function by the Mammalian Target of Rapamycin
Christine C. Hudson;Mei Liu;Gary G. Chiang;Diane M. Otterness.
Molecular and Cellular Biology (2002)
A role for ATR in the DNA damage-induced phosphorylation of p53
Randal S. Tibbetts;Kathryn M. Brumbaugh;Josie M. Williams;Jann N. Sarkaria.
Genes & Development (1999)
Inhibition of ATM and ATR Kinase Activities by the Radiosensitizing Agent, Caffeine
Jann N. Sarkaria;Ericka C. Busby;Randal S. Tibbetts;Pia Roos.
Cancer Research (1999)
Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin
Gregory J. Brunn;Christine C. Hudson;Aleksandar Sekulić;Josie M. Williams.
Isolation of a Protein Target of the FKBP12-Rapamycin Complex in Mammalian Cells
Candace J. Sabers;Mary M. Martin;Gregory J. Brunn;Josie M. Williams.
Journal of Biological Chemistry (1995)
A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells
Aleksandar Sekulić;Christine C. Hudson;James L. Homme;Peng Yin.
Cancer Research (2000)
Wortmannin, a Potent and Selective Inhibitor of Phosphatidylinositol-3-kinase
G Powis;R Bonjouklian;R Bonjouklian;M M Berggren;M M Berggren;A Gallegos;A Gallegos.
Cancer Research (1994)
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