Tarek S. Mansour

Overview

Best Publications

• Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin.

  Ker Yu;Lourdes Toral-Barza;Celine Shi;Wei-Guo Zhang

  419
  Citations

• Bis(morpholino-1,3,5-triazine) derivatives: potent adenosine 5'-triphosphate competitive phosphatidylinositol-3-kinase/mammalian target of rapamycin inhibitors: discovery of compound 26 (PKI-587), a highly efficacious dual inhibitor.

  Aranapakam M. Venkatesan;Christoph M. Dehnhardt;Efren Delos Santos;Zecheng Chen

  285
  Citations

• Acidity measurements on pyridines in tetrahydrofuran using lithiated silylamines

  Unknown

  249
  Citations

• Design and synthesis of monocyclic β-lactams as mechanism-based inhibitors of human cytomegalovirus protease

  Alan D. Borthwick;Gordon Weingarten;Terry M. Haley;Mirek Tomaszewski

  225
  Citations

• Kinase domain mutations in cancer: implications for small molecule drug design strategies.

  Jack A Bikker;Natasja Brooijmans;Allan Wissner;Tarek S Mansour

  219
  Citations

• Structure-Based Optimization of Protein Tyrosine Phosphatase 1B Inhibitors: From the Active Site to the Second Phosphotyrosine Binding Site

  Douglas P Wilson;Zhao-Kui Wan;Wei-Xin Xu;Steven J Kirincich

  177
  Citations

• Molecular mechanism of hepatitis C virus replicon variants with reduced susceptibility to a benzofuran inhibitor, HCV-796.

  Anita Y. M. Howe;Huiming Cheng;Stephen Johann;Stanley Mullen

  156
  Citations

• PROCESS FOR STEREOSELECTIVE SYNTHESIS OF NUCLEOSIDES DERIVATIVES

  Mansour Tarek;Tse Allan H

  153
  Citations

• A selective matrix metalloprotease 12 inhibitor for potential treatment of chronic obstructive pulmonary disease (COPD): discovery of (S)-2-(8-(methoxycarbonylamino)dibenzo[b,d]furan-3-sulfonamido)-3-methylbutanoic acid (MMP408).

  Wei Li;Jianchang Li;Yuchuan Wu;Junjun Wu

  151
  Citations

• ATP-Competitive Inhibitors of the Mammalian Target of Rapamycin: Design and Synthesis of Highly Potent and Selective Pyrazolopyrimidines.

  Arie Zask;Jeroen C. Verheijen;Kevin Curran;Joshua Kaplan

  144
  Citations

• β-Keto sulfones as inhibitors of 11β-hydroxysteroid dehydrogenase type I and the mechanism of action

  Jason Xiang;Manus Ipek;Vipin Suri;May Tam

  139
  Citations

• Discovery of pyrano[3,4-b]indoles as potent and selective HCV NS5B polymerase inhibitors

  Ariamala Gopalsamy;Kitae Lim;Gregory Ciszewski;Kaapjoo Park

  133
  Citations

• The scope and mechanism of phosphonium-mediated S(N)Ar reactions in heterocyclic amides and ureas.

  Zhao-Kui Wan;Sumrit Wacharasindhu;Christopher G. Levins;Melissa Lin

  122
  Citations

• An efficient direct amination of cyclic amides and cyclic ureas.

  Zhao-Kui Wan;Sumrit Wacharasindhu;Eva Binnun;Tarek Mansour

  117
  Citations

• Discovery of 4-(benzylaminomethylene)isoquinoline-1,3-(2H,4H)-diones and 4-[(pyridylmethyl)aminomethylene]isoquinoline-1,3-(2H,4H)-diones as potent and selective inhibitors of the cyclin-dependent kinase 4.

  Hwei-Ru Tsou;Xiaoxiang Liu;Gary Birnberg;Joshua Kaplan

  111
  Citations

• Anti-human immunodeficiency virus and anti-hepatitis-B virus activities and toxicities of the enantiomers of 2'-deoxy-3'-oxa-4'-thiocytidine and their 5-fluoro analogues in vitro.

  Tarek S. Mansour;Haolun Jin;Wei Wang;Elizabeth U. Hooker

  105
  Citations

• Phenyl thiazolyl urea and carbamate derivatives as new inhibitors of bacterial cell-wall biosynthesis.

  Gerardo D. Francisco;Zhong Li;J.Donald Albright;Nancy H. Eudy

  105
  Citations

• Lead Optimization of N-3-Substituted 7-Morpholinotriazolopyrimidines as Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitors: Discovery of PKI-402

  Christoph M. Dehnhardt;Aranapakam M. Venkatesan;Efren Delos Santos;Zecheng Chen

  103
  Citations

• Acidity measurements in THF. V. Heteroaromatic compounds containing 5-membered rings

  Unknown

  101
  Citations

• 2,4-Diamino-quinazolines as inhibitors of β-catenin/Tcf-4 pathway: Potential treatment for colorectal cancer

  Zecheng Chen;Aranapakam M. Venkatesan;Christoph M. Dehnhardt;Osvaldo Dos Santos

  100
  Citations

• Processes for preparing substituted 1,3-oxathiolanes with antiviral properties

  Bernard Belleau;Tarek Mansour;Allan Tse;Colleen A. Evans

  98
  Citations

• Anti-Human Immunodeficiency Virus Type 1 Activity, Intracellular Metabolism, and Pharmacokinetic Evaluation of 2′-Deoxy-3′-Oxa-4′-Thiocytidine

  J M de Muys;H Gourdeau;N Nguyen-Ba;D L Taylor

  95
  Citations