D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Chemistry D-index 68 Citations 19,213 654 World Ranking 2904 National Ranking 40
Biology and Biochemistry D-index 78 Citations 22,262 464 World Ranking 1961 National Ranking 31

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • DNA
  • Gene

Piet Herdewijn mostly deals with Biochemistry, Stereochemistry, Nucleic acid, Oligonucleotide and RNA. Biochemistry is closely attributed to Molecular biology in his work. The Stereochemistry study combines topics in areas such as Biological activity, Structure–activity relationship and Stereoisomerism.

The various areas that Piet Herdewijn examines in his Nucleic acid study include Nucleic acid structure, Oligoribonucleotides, DNA, RNase H and Phosphoramidite. Solid-phase synthesis and Nucleobase is closely connected to Base pair in his research, which is encompassed under the umbrella topic of Oligonucleotide. His RNA research is multidisciplinary, relying on both Duplex and Transfection.

His most cited work include:

  • Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds (1426 citations)
  • Synthetic genetic polymers capable of heredity and evolution (446 citations)
  • Both 2′,3′-dideoxythymidine and its 2′,3′-unsaturated derivative (2′,3′-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitro (305 citations)

What are the main themes of his work throughout his whole career to date?

Piet Herdewijn mainly investigates Stereochemistry, Biochemistry, Nucleic acid, Oligonucleotide and Nucleoside. His study in Stereochemistry is interdisciplinary in nature, drawing from both Base pair, DNA and Nucleotide. As a part of the same scientific study, Piet Herdewijn usually deals with the Nucleotide, concentrating on Polymerase and frequently concerns with DNA polymerase.

His research in Biochemistry intersects with topics in Molecular biology and Thymidine kinase. His Nucleic acid study combines topics in areas such as RNA, Nucleic acid structure, Duplex and Nucleic acid analogue. In most of his Oligonucleotide studies, his work intersects topics such as Combinatorial chemistry.

He most often published in these fields:

  • Stereochemistry (52.91%)
  • Biochemistry (28.42%)
  • Nucleic acid (24.11%)

What were the highlights of his more recent work (between 2012-2021)?

  • Stereochemistry (52.91%)
  • Biochemistry (28.42%)
  • Nucleic acid (24.11%)

In recent papers he was focusing on the following fields of study:

Piet Herdewijn mainly focuses on Stereochemistry, Biochemistry, Nucleic acid, Nucleotide and DNA. He has researched Stereochemistry in several fields, including Prodrug, Base pair and Nucleobase. His research investigates the link between Base pair and topics such as In vivo that cross with problems in In vitro.

He has included themes like Molecular biology and Aptamer in his Biochemistry study. His studies deal with areas such as Oligonucleotide, RNA, Computational biology, Synthetic biology and Combinatorial chemistry as well as Nucleic acid. His Nucleotide research includes elements of Polymerase and Substrate.

Between 2012 and 2021, his most popular works were:

  • Catalysts from synthetic genetic polymers (140 citations)
  • Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral (130 citations)
  • Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects (107 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • DNA
  • Gene

His primary areas of investigation include Biochemistry, Stereochemistry, Nucleic acid, DNA and Nucleotide. Piet Herdewijn frequently studies issues relating to Molecular biology and Biochemistry. Piet Herdewijn studies Stereochemistry, namely Nucleoside.

His Nucleic acid study integrates concerns from other disciplines, such as RNA, Transfer RNA, mdx mouse, Synthetic biology and Xeno nucleic acid. The concepts of his DNA study are interwoven with issues in Xenobiology, Nucleoside triphosphate, Guanine, Derivatization and Agarose. Piet Herdewijn interconnects Phosphodiesterase, Moiety, Substrate and Alkaline phosphatase in the investigation of issues within Nucleotide.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds

Rudi Pauwels;Jan Balzarini;Masanori Baba;Robert Snoeck.
Journal of Virological Methods (1988)

2327 Citations

Synthetic genetic polymers capable of heredity and evolution

Vitor B. Pinheiro;Alexander I. Taylor;Christopher Cozens;Mikhail Abramov.
Science (2012)

594 Citations

Both 2′,3′-dideoxythymidine and its 2′,3′-unsaturated derivative (2′,3′-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitro

Masanori Baba;Rudi Pauwels;Piet Herdewijn;Erik De Clercq.
Biochemical and Biophysical Research Communications (1987)

474 Citations

3'-substituted 2',3'-dideoxynucleoside analogues as potential anti-HIV (HTLV-III/LAV) agents.

Piet Herdewijn;Jan Balzarini;Erik De Clercq;Rudi Pauwels.
Journal of Medicinal Chemistry (1987)

468 Citations

Differential patterns of intracellular metabolism of 2',3'-didehydro-2',3'-dideoxythymidine and 3'-azido-2',3'-dideoxythymidine, two potent anti-human immunodeficiency virus compounds.

J Balzarini;P Herdewijn;E De Clercq.
Journal of Biological Chemistry (1989)

432 Citations

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

Jesper B. Bramsen;Maria B. Laursen;Anne F. Nielsen;Thomas B. Hansen.
Nucleic Acids Research (2009)

358 Citations

The anti-HTLV-III (anti-HIV) and cytotoxic activity of 2',3'-didehydro-2',3'-dideoxyribonucleosides: a comparison with their parental 2',3'-dideoxyribonucleosides.

J Balzarini;G J Kang;M Dalal;P Herdewijn.
Molecular Pharmacology (1987)

335 Citations

Modifications in Lignin and Accumulation of Phenolic Glucosides in Poplar Xylem upon Down-regulation of Caffeoyl-Coenzyme A O-Methyltransferase, an Enzyme Involved in Lignin Biosynthesis

Hugo Meyermans;Kris Morreel;Catherine Lapierre;Brigitte Pollet.
Journal of Biological Chemistry (2000)

327 Citations

Intracellular metabolism and mechanism of anti-retrovirus action of 9-(2-phosphonylmethoxyethyl)adenine, a potent anti-human immunodeficiency virus compound.

J. Balzarini;Zhang Hao;P. Herdewijn;D. G. Johns.
Proceedings of the National Academy of Sciences of the United States of America (1991)

295 Citations

Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent.

J Balzarini;L Naesens;P Herdewijn;I Rosenberg.
Proceedings of the National Academy of Sciences of the United States of America (1989)

256 Citations

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