Piet Herdewijn mostly deals with Biochemistry, Stereochemistry, Nucleic acid, Oligonucleotide and RNA. Biochemistry is closely attributed to Molecular biology in his work. The Stereochemistry study combines topics in areas such as Biological activity, Structure–activity relationship and Stereoisomerism.
The various areas that Piet Herdewijn examines in his Nucleic acid study include Nucleic acid structure, Oligoribonucleotides, DNA, RNase H and Phosphoramidite. Solid-phase synthesis and Nucleobase is closely connected to Base pair in his research, which is encompassed under the umbrella topic of Oligonucleotide. His RNA research is multidisciplinary, relying on both Duplex and Transfection.
Piet Herdewijn mainly investigates Stereochemistry, Biochemistry, Nucleic acid, Oligonucleotide and Nucleoside. His study in Stereochemistry is interdisciplinary in nature, drawing from both Base pair, DNA and Nucleotide. As a part of the same scientific study, Piet Herdewijn usually deals with the Nucleotide, concentrating on Polymerase and frequently concerns with DNA polymerase.
His research in Biochemistry intersects with topics in Molecular biology and Thymidine kinase. His Nucleic acid study combines topics in areas such as RNA, Nucleic acid structure, Duplex and Nucleic acid analogue. In most of his Oligonucleotide studies, his work intersects topics such as Combinatorial chemistry.
Piet Herdewijn mainly focuses on Stereochemistry, Biochemistry, Nucleic acid, Nucleotide and DNA. He has researched Stereochemistry in several fields, including Prodrug, Base pair and Nucleobase. His research investigates the link between Base pair and topics such as In vivo that cross with problems in In vitro.
He has included themes like Molecular biology and Aptamer in his Biochemistry study. His studies deal with areas such as Oligonucleotide, RNA, Computational biology, Synthetic biology and Combinatorial chemistry as well as Nucleic acid. His Nucleotide research includes elements of Polymerase and Substrate.
His primary areas of investigation include Biochemistry, Stereochemistry, Nucleic acid, DNA and Nucleotide. Piet Herdewijn frequently studies issues relating to Molecular biology and Biochemistry. Piet Herdewijn studies Stereochemistry, namely Nucleoside.
His Nucleic acid study integrates concerns from other disciplines, such as RNA, Transfer RNA, mdx mouse, Synthetic biology and Xeno nucleic acid. The concepts of his DNA study are interwoven with issues in Xenobiology, Nucleoside triphosphate, Guanine, Derivatization and Agarose. Piet Herdewijn interconnects Phosphodiesterase, Moiety, Substrate and Alkaline phosphatase in the investigation of issues within Nucleotide.
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Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds
Rudi Pauwels;Jan Balzarini;Masanori Baba;Robert Snoeck.
Journal of Virological Methods (1988)
Synthetic genetic polymers capable of heredity and evolution
Vitor B. Pinheiro;Alexander I. Taylor;Christopher Cozens;Mikhail Abramov.
Both 2′,3′-dideoxythymidine and its 2′,3′-unsaturated derivative (2′,3′-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitro
Masanori Baba;Rudi Pauwels;Piet Herdewijn;Erik De Clercq.
Biochemical and Biophysical Research Communications (1987)
3'-substituted 2',3'-dideoxynucleoside analogues as potential anti-HIV (HTLV-III/LAV) agents.
Piet Herdewijn;Jan Balzarini;Erik De Clercq;Rudi Pauwels.
Journal of Medicinal Chemistry (1987)
Differential patterns of intracellular metabolism of 2',3'-didehydro-2',3'-dideoxythymidine and 3'-azido-2',3'-dideoxythymidine, two potent anti-human immunodeficiency virus compounds.
J Balzarini;P Herdewijn;E De Clercq.
Journal of Biological Chemistry (1989)
A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity
Jesper B. Bramsen;Maria B. Laursen;Anne F. Nielsen;Thomas B. Hansen.
Nucleic Acids Research (2009)
The anti-HTLV-III (anti-HIV) and cytotoxic activity of 2',3'-didehydro-2',3'-dideoxyribonucleosides: a comparison with their parental 2',3'-dideoxyribonucleosides.
J Balzarini;G J Kang;M Dalal;P Herdewijn.
Molecular Pharmacology (1987)
Modifications in Lignin and Accumulation of Phenolic Glucosides in Poplar Xylem upon Down-regulation of Caffeoyl-Coenzyme A O-Methyltransferase, an Enzyme Involved in Lignin Biosynthesis
Hugo Meyermans;Kris Morreel;Catherine Lapierre;Brigitte Pollet.
Journal of Biological Chemistry (2000)
Intracellular metabolism and mechanism of anti-retrovirus action of 9-(2-phosphonylmethoxyethyl)adenine, a potent anti-human immunodeficiency virus compound.
J. Balzarini;Zhang Hao;P. Herdewijn;D. G. Johns.
Proceedings of the National Academy of Sciences of the United States of America (1991)
Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent.
J Balzarini;L Naesens;P Herdewijn;I Rosenberg.
Proceedings of the National Academy of Sciences of the United States of America (1989)
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