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Chemistry

D-Index
46
Citations
8716
World Ranking
15943
National Ranking
131

Overview

Erik B. Pedersen is affiliated with the University of Southern Denmark in Denmark and has contributed to research primarily in the fields of Biochemistry, Genetics, and Molecular Biology, with a focus on Molecular Biology and Organic Chemistry. Their work also touches on Oncology, Spectroscopy, and Materials Chemistry.

The main topics of Pedersen's research include:

  • DNA and Nucleic Acid Chemistry
  • PARP inhibition in cancer therapy
  • DNA Repair Mechanisms
  • Cell death mechanisms and regulation
  • Synthesis and Biological Evaluation
  • Synthesis and biological activity
  • Cancer therapeutics and mechanisms

Pedersen has published in several scientific journals, with a notable presence in:

  • ChemistrySelect (2 publications)
  • International Journal of Molecular Sciences (1 publication)
  • Indonesian Journal of Chemistry (1 publication)
  • Organic & Biomolecular Chemistry (1 publication)

Frequent coauthors collaborating with Pedersen include Maha I. Fatthalla, with whom they have coauthored three papers, as well as Giorgio Cinque, Annalisa Ferino, Luigi E. Xodo, and Manal El-Saidi associated with one publication each.

Selected recent papers authored or coauthored by Erik B. Pedersen are:

  • Role of Poly [ADP-ribose] Polymerase 1 in Activating the Kirsten ras (KRAS) Gene in Response to Oxidative Stress, 2020, International Journal of Molecular Sciences
  • Synthesis, Characterization and Docking Study of Novel Pyrimidine Derivatives as Anticancer Agents, 2020, Indonesian Journal of Chemistry
  • Hoogsteen triplexes stabilized through ethynyl-linked pyrene-indole synthesized by high-temperature Sonogashira coupling, 2022, Organic & Biomolecular Chemistry
  • Enone as TFO Linker: Synthesis and Parallel DNA Triplex Stability Evaluation, 2022, ChemistrySelect
  • Evaluation of the Base-Pairing Properties of 5-(5-Indolylethynyl) and 5-(5-Indolyl)-2'-deoxyuridine Modified Triplex and Duplex, 2020, ChemistrySelect

Pedersen's research contributions focus on molecular mechanisms related to DNA structure and stability, chemical synthesis of biologically relevant molecules, and exploring therapeutic strategies targeting cancer through the modulation of DNA repair and cell death pathways.

Best Publications

  • Intercalating nucleic acids containing insertions of 1-O-(1-pyrenylmethyl)glycerol: stabilisation of dsDNA and discrimination of DNA over RNA

    Ulf B. Christensen;Erik B. Pedersen

  • Recent basic research in hydrodesulfurization catalysis

    Henrik Topsoee;Bjerne S. Clausen;Nan Yu Topsoee;Erik Pedersen

  • Synthesis and Anti-HIV-1 Activity of Novel 2,3-Dihydro-7H-thiazolo[3,2-a]pyrimidin-7-ones

    Krzysztof Danel;Erik B. Pedersen;Claus Nielsen

  • Synthesis of Triazenopyrazole Derivativesas Potential Inhibitors of HIV-1

    Janus S. Larsen;Magdy A. Zahran;Erik B. Pedersen;Claus Nielsen

  • ESR characterization of trans-diacidatotetrakis(pyridine)vanadium and -manganese trans-VII(py)4X2 and trans-MnII(py)4X2 (X = NCS, Cl, Br, I; py = pyridine)

    Claus J. H. Jacobsen;Erik Pedersen;Joergen Villadsen;Hoegni Weihe

  • S-Glucosylated hydantoins as new antiviral agents

    Ahmed A. El-Barbary;Ahmed I. Khodair;Erik B. Pedersen;Claus Nielsen

  • Non-nucleoside reverse transcriptase inhibitors: the NNRTI boom.

    Ole S Pedersen;Erik B Pedersen

  • Stable and selective formation of hoogsteen-type triplexes and duplexes using twisted intercalating nucleic acids (TINA) prepared via postsynthetic Sonogashira solid-phase coupling reactions.

    Vyacheslav V. Filichev;Erik B. Pedersen

  • Electron spin resonance spectra of tetragonal chromium(III) complexes. I. trans-[Cr(NH3)4XY]n+ and trans-Cr(py)4XY]n+ in frozen solutions and powders. Correlation between zero-field splittings and ligand field parameters via complete d-electron calculations

    Erik. Pedersen;Hans. Toftlund

  • The regulatory G4 motif of the Kirsten ras (KRAS) gene is sensitive to guanine oxidation: implications on transcription.

    Susanna Cogoi;Annalisa Ferino;Giulia Miglietta;Erik B Pedersen

  • MAZ-binding G4-decoy with locked nucleic acid and twisted intercalating nucleic acid modifications suppresses KRAS in pancreatic cancer cells and delays tumor growth in mice

    Susanna Cogoi;Sonia Zorzet;Valentina Rapozzi;Imrich Géci

  • Binuclear bis(.mu.-oxo)dimanganese(III,IV) and -(IV,IV) complexes with N,N'-bis(2-pyridylmethyl)-1,2-ethanediamine

    Patricia A. Goodson;Joergen Glerup;Derek J. Hodgson;Kirsten Michelsen

  • G4-DNA formation in the HRAS promoter and rational design of decoy oligonucleotides for cancer therapy.

    Alexandro Membrino;Susanna Cogoi;Erik B. Pedersen;Luigi E. Xodo

  • The Flourishing Syntheses of Non-Nucleoside Reverse Transcriptase Inhibitors

    Ole S. Pedersen;Erik B. Pedersen

  • A double staining technique for simultaneous demonstration of astrocytes and microglia in brain sections and astroglial cell cultures

    B Castellano;B González;M B Jensen;E B Pedersen

  • Preparation of Chromium(III) Complexes with Two Fluorine Atoms and Four Nitrogen Atoms as Ligators. trans-Difluorotetrakis(pyridine)chromium(III) Salts as Initial Materials.

    Jørgen Glerup;Jens Josephsen;Kirsten Michelsen;Erik Pedersen

  • Synthesis and potent anti-HIV-1 activity of novel 6-benzyluracil analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine.

    Krzysztof Danel;Erik Larsen;Erik B. Pedersen;Bent F. Vestergaard

  • Magnetic and electrochemical properties of transition metal complexes with multiple metal-to-metal bonds. II. Tetrabutyratodiruthenium(n+) with n = 0 and 1

    F. Albert. Cotton;Erik. Pedersen

  • Magnetic Properties and Molecular Structure of the mu-Oxo-bis{pentaamminechromium(III)} Ion.

    Erik Pedersen;Ingmar Grenthe;Veikko Nurmikko;Jean Galy

  • A Novel Correlation between Magnetism and Structural Parameters in Superexchange Coupled Chromium(III) Dimers.

    Jørgen Glerup;Derek J. Hodgson;Erik Pedersen;Arne Haaland

  • Identification of a new G-quadruplex motif in the KRAS promoter and design of pyrene-modified G4-decoys with antiproliferative activity in pancreatic cancer cells.

    Susanna Cogoi;Manikandan Paramasivam;Vyacheslav Filichev;Imrich Géci

  • Stabilization of parallel triplexes by twisted intercalating nucleic acids (TINAs) incorporating 1,2,3-triazole units and prepared by microwave-accelerated click chemistry.

    Imrich Géci;Vyacheslav V. Filichev;Vyacheslav V. Filichev;Erik B. Pedersen

  • Raman spectra of amorphous Al2O3 and Al2O3/MoO3 obtained by visible and infrared excitation

    A. Mortensen;D. H. Christensen;O. Faurskov Nielsen;E. Pedersen

Frequent Co-Authors

Claus Henrik Nielsen
Claus Henrik Nielsen Copenhagen University Hospital
Claus J. Nielsen
Claus J. Nielsen University of Oslo
Jesper Wengel
Jesper Wengel Aalborg University
Paolo La Colla
Paolo La Colla University of Cagliari
Derek J. Hodgson
Derek J. Hodgson University of North Carolina at Chapel Hill
Sine Larsen
Sine Larsen University of Copenhagen
F. Albert Cotton
F. Albert Cotton Texas A&M University
Arne Haaland
Arne Haaland University of Oslo
Poul Erik Hansen
Poul Erik Hansen Roskilde University
Lars Porskjær Christensen
Lars Porskjær Christensen University of Southern Denmark

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