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Chemistry

D-Index
43
Citations
8742
World Ranking
17095
National Ranking
140

Overview

Sine Larsen was a researcher affiliated with the University of Copenhagen in Denmark. Their scientific contributions spanned several disciplines, predominantly bridging Arts and Humanities with Biochemistry, Genetics, and Molecular Biology.

Their research covered diverse fields of study, including Molecular Biology, Archeology, Materials Chemistry, General Health Professions, and Earth-Surface Processes. This broad range reflected an interdisciplinary approach, connecting biological sciences with cultural and material heritage.

Main topics addressed in their work were:

  • Enzyme Structure and Function
  • Protein Structure and Dynamics
  • Cultural Heritage Materials Analysis
  • Building Materials and Conservation
  • Conservation Techniques and Studies
  • Microbial Metabolic Engineering and Bioproduction
  • Fermentation and Sensory Analysis

Their publication record included articles in various respected venues such as:

  • Proceedings of the National Academy of Sciences
  • Nature Communications
  • IUCrJ
  • Structure
  • Acta Crystallographica Section D Structural Biology

Notable recent papers by Larsen included:

  • Insights into the composition of ancient Egyptian red and black inks on papyri achieved by synchrotron-based microanalyses, 2020, Proceedings of the National Academy of Sciences
  • The structural basis of fungal glucuronoyl esterase activity on natural substrates, 2020, Nature Communications
  • Structural insights into protein folding, stability and activity using in vivo perdeuteration of hen egg-white lysozyme, 2021, IUCrJ
  • The impact of folding modes and deuteration on the atomic resolution structure of hen egg-white lysozyme, 2021, Acta Crystallographica Section D Structural Biology
  • Structure and dynamics of the active site of hen egg-white lysozyme from atomic resolution neutron crystallography, 2024, Structure

Larsen also contributed to the academic book domain with a publication titled Structure, mechanism, and evolution of organophosphorus hydrolase from Deinococcus radiodurans, released in 2025 by La Trobe University.

Frequent co-authors during Larsen's career included:

  • Annette E. Langkilde
  • João Ramos
  • Valérie Laux
  • Michael Haertlein
  • V. Trevor Forsyth

Best Publications

  • Stimulation of lignocellulosic biomass hydrolysis by proteins of glycoside hydrolase family 61: structure and function of a large, enigmatic family

    Paul V Harris;Ditte Welner;K C McFarland;Edward Re

  • Rhamnogalacturonan acetylesterase elucidates the structure and function of a new family of hydrolases

    Anne Mølgaard;Sakari Kauppinen;Sine Larsen

  • Structural and Functional Insight into How the Plasmodium falciparum VAR2CSA Protein Mediates Binding to Chondroitin Sulfate A in Placental Malaria

    Thomas M. Clausen;Stig Christoffersen;Madeleine Dahlbäck;Annette Eva Langkilde

  • Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes

    Wade Abbott;Orly Alber;Ed Bayer;Jean-Guy Berrin

  • The crystal structure of rhamnogalacturonase A from Aspergillus aculeatus: a right-handed parallel β helix

    Thomas Nordahl Petersen;S. Kauppinen;Sine Larsen

  • Structure of the Sulfolobus solfataricus α-Glucosidase: Implications for Domain Conservation and Substrate Recognition in GH31

    Heidi A. Ernst;Leila Lo Leggio;Martin Willemoës;Gordon Leonard

  • Structural basis for the catalytic mechanism of a proficient enzyme: orotidine 5'-monophosphate decarboxylase.

    Pernille Harris;§ Jens-Christian Navarro Poulsen;and Kaj Frank Jensen;Sine Larsen

  • Structural basis for the function of Bacillus subtilis phosphoribosyl-pyrophosphate synthetase.

    Tine A. Eriksen;Anders Kadziola;Ann-Kristin Bentsen;Kenneth W. Harlow

  • Active Site of Dihydroorotate Dehydrogenase A from Lactococcus lactis Investigated by Chemical Modification and Mutagenesis

    Olof Björnberg;Paul Rowland;Sine Larsen;Kaj Frank Jensen

  • Structures of β-Ketoacyl-Acyl Carrier Protein Synthase I Complexed with Fatty Acids Elucidate its Catalytic Machinery

    Johan Gotthardt Olsen;Anders Kadziola;Penny von Wettstein-Knowles;Mads Siggaard-Andersen

  • Crystal structure of the tetrameric cytidine deaminase from Bacillus subtilis at 2.0 A resolution.

    Eva Johansson;Nina Mejlhede;Jan Neuhard;Sine Larsen

  • The X-ray crystal structure of β-ketoacyl [acyl carrier protein] synthase I

    Johan Gotthardt Olsen;Johan Gotthardt Olsen;Anders Kadziola;Anders Kadziola;Penny von Wettstein-Knowles;Mads Siggaard-Andersen

  • Charge Density Study of Naphthalene Based on X-ray Diffraction Data at Four Different Temperatures and Theoretical Calculations

    Jette Oddershede;Sine Larsen

  • The crystal structure of the flavin containing enzyme dihydroorotate dehydrogenase A from Lactococcus lactis

    Paul Rowland;Finn S Nielsen;Kaj Frank Jensen;Sine Larsen

  • Three-dimensional structure of a recombinant peroxidase from Coprinus cinereus at 2.6 A resolution.

    Jens F.W. Petersen;Anders Kadziola;Sine Larsen

  • Experimental Charge-Density Study of Methylammonium Hydrogen Succinate Monohydrate - A Salt with a Very Short O-H-O Hydrogen-Bond

    Claus Flensburg;Sine Larsen;Robert F. Stewart

  • Automation of sample mounting for macromolecular crystallography.

    F. Cipriani;F. Felisaz;L. Launer;J.-S. Aksoy

  • E. coli Dihydroorotate Dehydrogenase Reveals Structural and Functional Distinctions between Different Classes of Dihydroorotate Dehydrogenases

    Sofie Nørager;Kaj Frank Jensen;Olof Björnberg;Sine Larsen

  • The 1.62 Å structure of Thermoascus aurantiacus endoglucanase: completing the structural picture of subfamilies in glycoside hydrolase family 5

    Leila Lo Leggio;Sine Larsen

  • The crystal structure of lactococcus lactis dihydroorotate dehydrogenase A complexed with the enzyme reaction product throws light on its enzymatic function

    P Rowland;O Björnberg;F S Nielsen;K F Jensen

Frequent Co-Authors

Eva Johansson
Eva Johansson Swedish University of Agricultural Sciences
Erik B. Pedersen
Erik B. Pedersen University of Southern Denmark
Svante Wold
Svante Wold Umeå University
Dušan Turk
Dušan Turk Jožef Stefan Institute
Giovanni Sindona
Giovanni Sindona University of Calabria
Carl Erik Olsen
Carl Erik Olsen University of Copenhagen
Michael A. McDonough
Michael A. McDonough University of Oxford
Peter E. Andersen
Peter E. Andersen Technical University of Denmark
Ali Salanti
Ali Salanti Copenhagen University Hospital
Kell Mortensen
Kell Mortensen University of Copenhagen

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