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Biology and Biochemistry

D-Index
104
Citations
32492
World Ranking
1277
National Ranking
749

Research.com Recognitions

  • 2020 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Charles O. Rock is affiliated with St. Jude Children's Research Hospital in the United States. Their research primarily focuses on fields within Biochemistry, Genetics, and Molecular Biology, with significant contributions to Medicine as well. Their work spans across several subfields, including Molecular Biology, Genetics, Materials Chemistry, Infectious Diseases, and Epidemiology.

Rock's investigations cover a diverse range of main topics, highlighting RNA and protein synthesis mechanisms, bacterial genetics and biotechnology, enzyme structure and function, antimicrobial resistance in Staphylococcus, metabolism and genetic disorders, neurological diseases and metabolism, and microbial natural products and biosynthesis.

Frequent publication venues for their work include the Journal of Biological Chemistry, bioRxiv (Cold Spring Harbor Laboratory), The FASEB Journal, mSphere, and the Journal of Structural Biology.

Among their recent research papers are:

  • "A bacterial pan-genome makes gene essentiality strain-dependent and evolvable" (2022, Nature Microbiology)
  • "Host Fatty Acid Utilization by Staphylococcus aureus at the Infection Site" (2020, mBio)
  • "Branched-chain amino acid metabolism controls membrane phospholipid structure in Staphylococcus aureus" (2021, Journal of Biological Chemistry)
  • "Mining Fatty Acid Biosynthesis for New Antimicrobials" (2022, Annual Review of Microbiology)
  • "Role of the pyruvate metabolic network on carbohydrate metabolism and virulence in Streptococcus pneumoniae" (2020, Molecular Microbiology)

Rock frequently collaborates with several coauthors who have contributed to multiple publications, including Matthew W. Frank, Christopher D. Radka, Chitra Subramanian, and Stephen W. White.

In 2020, Rock was recognized as a Fellow of the American Association for the Advancement of Science (AAAS).

Best Publications

  • Membrane lipid homeostasis in bacteria.

    Yong-Mei Zhang;Charles O. Rock

  • THE STRUCTURAL BIOLOGY OF TYPE II FATTY ACID BIOSYNTHESIS

    Stephen W. White;Jie Zheng;Yo ng-Mei Zhang;Charles O. Rock

  • Regulation of fatty acid biosynthesis in Escherichia coli.

    K Magnuson;S Jackowski;C O Rock;J E Cronan

  • Mechanism of Triclosan Inhibition of Bacterial Fatty Acid Synthesis

    Richard J. Heath;J. Ronald Rubin;Debra R. Holland;Erli Zhang

  • Coenzyme A: back in action.

    Roberta Leonardi;Yong-Mei Zhang;Charles O. Rock;Suzanne Jackowski

  • Biosynthesis of Membrane Lipids.

    John E. Cronan;Charles O. Rock

  • Enoyl-acyl carrier protein-reductase (fabI) plays a determinant role in completing cycles of fatty acid elongation in Escherichia coli

    Richard J. Heath;Charles O. Rock;Charles O. Rock

  • BROAD SPECTRUM ANTIMICROBIAL BIOCIDES TARGET THE FABI COMPONENT OF FATTY ACID SYNTHESIS

    Richard J. Heath;Yuen-Tsu Yu;Martin A. Shapiro;Eric Olson

  • Bacterial lipids: Metabolism and membrane homeostasis

    Joshua B. Parsons;Charles O. Rock

  • Lipid biosynthesis as a target for antibacterial agents.

    Richard J. Heath;Stephen W. White;Stephen W. White;Charles O. Rock;Charles O. Rock

  • Escherichia coli as a model for the regulation of dissociable (type II) fatty acid biosynthesis

    Charles O. Rock;John E. Cronan

  • Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism.

    Allen C. Price;Keum-Hwa Choi;Richard J. Heath;Zhenmei Li

  • A triclosan-resistant bacterial enzyme

    Richard J. Heath;Charles O. Rock;Charles O. Rock

  • Isolation and characterization of the beta-ketoacyl-acyl carrier protein synthase III gene (fabH) from Escherichia coli K-12.

    J T Tsay;W Oh;T J Larson;S Jackowski

  • Roles of the FabA and FabZ β-Hydroxyacyl-Acyl Carrier Protein Dehydratases in Escherichia coli Fatty Acid Biosynthesis

    Richard J. Heath;Charles O. Rock;Charles O. Rock

  • β-Ketoacyl-Acyl Carrier Protein Synthase III (FabH) Is a Determining Factor in Branched-Chain Fatty Acid Biosynthesis

    Keum-Hwa Choi;Richard J. Heath;Charles O. Rock;Charles O. Rock

  • Regulation of Fatty Acid Elongation and Initiation by Acyl-Acyl Carrier Protein in Escherichia coli

    Richard J. Heath;Charles O. Rock;Charles O. Rock

  • The 1.8 Å crystal structure and active-site architecture of β-ketoacyl-acyl carrier protein synthase III (FabH) from Escherichia coli

    Christopher Davies;Richard J Heath;Stephen W White;Stephen W White;Charles O Rock;Charles O Rock

  • Inhibition of the Staphylococcus aureusNADPH-dependent Enoyl-Acyl Carrier Protein Reductase by Triclosan and Hexachlorophene

    Richard J. Heath;Jing Li;Gregory E. Roland;Charles O. Rock;Charles O. Rock

  • Inhibiting bacterial fatty acid synthesis

    Yong-Mei Zhang;Stephen W. White;Charles O. Rock

Frequent Co-Authors

Suzanne Jackowski
Suzanne Jackowski St. Jude Children's Research Hospital
Yong-Mei Zhang
Yong-Mei Zhang Medical University of South Carolina
Stephen W. White
Stephen W. White St. Jude Children's Research Hospital
Richard E. Lee
Richard E. Lee St. Jude Children's Research Hospital
John E. Cronan
John E. Cronan University of Illinois at Urbana-Champaign
Jie Zheng
Jie Zheng University of California, Los Angeles
Diego de Mendoza
Diego de Mendoza National University of Rosario
Herbert P. Schweizer
Herbert P. Schweizer Colorado State University
Masoud Vedadi
Masoud Vedadi Structural Genomics Consortium
Geoffrey Neale
Geoffrey Neale St. Jude Children's Research Hospital

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