World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
64
Citations
15235
World Ranking
9626
National Ranking
4251

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Gene
  • Biochemistry

Richard E. Lee mostly deals with Biochemistry, Mycobacterium tuberculosis, Microbiology, Enzyme and Pharmacology. His work on Coenzyme A, Pantothenate kinase and Pterin as part of general Biochemistry research is often related to Dihydropteroate synthase, thus linking different fields of science. His research in Mycobacterium tuberculosis intersects with topics in Pharmacophore and Cytotoxicity.

His Microbiology research incorporates elements of Fatty acid, Membrane, Gene and Bacteria. Richard E. Lee interconnects Antibacterial agent and Stereochemistry in the investigation of issues within Enzyme. Drug tolerance, Cell biology, Membrane potential, ATP synthase and Cell membrane is closely connected to Drug resistance in his research, which is encompassed under the umbrella topic of Pharmacology.

His most cited work include:

  • Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections. (470 citations)
  • Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane (274 citations)
  • Genome-Wide Expression Profiling of the Response to Azole, Polyene, Echinocandin, and Pyrimidine Antifungal Agents in Candida albicans (255 citations)

What are the main themes of his work throughout his whole career to date?

The scientist’s investigation covers issues in Biochemistry, Stereochemistry, Microbiology, Enzyme and Antibiotics. He carries out multidisciplinary research, doing studies in Biochemistry and Dihydropteroate synthase. The various areas that Richard E. Lee examines in his Stereochemistry study include Antibacterial activity, Structure–activity relationship, Antibacterial agent and Transferase.

As part of the same scientific family, Richard E. Lee usually focuses on Microbiology, concentrating on Staphylococcus aureus and intersecting with Bacillus anthracis. Richard E. Lee combines subjects such as Biofilm, Pharmacology and Drug resistance with his study of Antibiotics. The Pharmacology study combines topics in areas such as In vivo and Mycobacterium tuberculosis.

He most often published in these fields:

  • Biochemistry (41.44%)
  • Stereochemistry (26.52%)
  • Microbiology (21.55%)

What were the highlights of his more recent work (between 2018-2021)?

  • Antibiotics (18.23%)
  • Microbiology (21.55%)
  • Pharmacology (19.34%)

In recent papers he was focusing on the following fields of study:

His primary areas of investigation include Antibiotics, Microbiology, Pharmacology, Biochemistry and Mycobacterium tuberculosis. His work on Moraxella catarrhalis, Streptococcus pneumoniae and Haemophilus influenzae as part of his general Antibiotics study is frequently connected to Ear infection, thereby bridging the divide between different branches of science. His work in the fields of Microbiology, such as Antibacterial agent, overlaps with other areas such as Respiratory tract infections.

His Pharmacology research incorporates themes from Pyridoxal and In vivo. His research ties Boron and Biochemistry together. His work carried out in the field of Mycobacterium tuberculosis brings together such families of science as Streptomycin, Kanamycin, Dehydratase and Mycobacterium.

Between 2018 and 2021, his most popular works were:

  • Advancing Translational Science for Pulmonary Nontuberculous Mycobacterial Infections. A Road Map for Research. (20 citations)
  • De novo design of boron-based peptidomimetics as potent inhibitors of human ClpP in the presence of human ClpX. (9 citations)
  • Ureadepsipeptides as ClpP Activators. (8 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Gene
  • Amino acid

His primary scientific interests are in Biochemistry, Pharmacology, Antibiotics, In vivo and Antibacterial activity. Biochemistry connects with themes related to Boron in his study. His Pharmacology study integrates concerns from other disciplines, such as Anti tuberculosis and Mycobacterium tuberculosis.

His work deals with themes such as Francisella tularensis, Burkholderia pseudomallei, Burkholderia mallei and Bacillus anthracis, which intersect with Antibiotics. As part of his studies on Burkholderia pseudomallei, Richard E. Lee often connects relevant subjects like Microbiology. His Antibacterial activity research includes elements of Protease, Potency, Staphylococcus aureus and Biofilm.

Best Publications

  • Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections

    Julian G. Hurdle;Alex J. O'Neill;Ian Chopra;Richard E. Lee

  • Mycolactone: A Polyketide Toxin from Mycobacterium ulcerans Required for Virulence

    Kathleen M. George;Delphi Chatterjee;Geewananda Gunawardana;Diane Welty

  • Biased Signaling Pathways in β2-Adrenergic Receptor Characterized by 19F-NMR

    Jeffrey J. Liu;Reto Horst;Vsevolod Katritch;Raymond C. Stevens

  • Validation of molecular docking programs for virtual screening against dihydropteroate synthase.

    Kirk E. Hevener;Wei Zhao;Wei Zhao;David M. Ball;David M. Ball;Kerim Babaoglu;Kerim Babaoglu

  • Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane

    Anna E Grzegorzewicz;Ha Pham;Vijay A K B Gundi;Michael S Scherman

  • Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans.

    Timothy Paul Stinear;Armand Mve-Obiang;Pamela L C Small;Wafa Frigui

  • Genome-Wide Expression Profiling of the Response to Azole, Polyene, Echinocandin, and Pyrimidine Antifungal Agents in Candida albicans

    Teresa T. Liu;Robin E. B. Lee;Katherine S. Barker;Richard E. Lee

  • New agents for the treatment of drug-resistant Mycobacterium tuberculosis

    Daniel T. Hoagland;Jiuyu Liu;Robin B. Lee;Richard E. Lee

  • Novel inhibitors of an emerging target in Mycobacterium tuberculosis; substituted thiazolidinones as inhibitors of dTDP-rhamnose synthesis.

    Kerim Babaoglu;Mark A. Page;Victoria C. Jones;Michael R. McNeil

  • Identification of a gene involved in the biosynthesis of cyclopropanated mycolic acids in Mycobacterium tuberculosis.

    Ying Yuan;Richard E. Lee;Gurdyal S. Besra;John T. Belisle

  • Catalysis and sulfa drug resistance in dihydropteroate synthase.

    Mi Kyung Yun;Yinan Wu;Yinan Wu;Zhenmei Li;Ying Zhao

  • Heterogeneity of mycolactones produced by clinical isolates of Mycobacterium ulcerans: implications for virulence.

    Armand Mve-Obiang;Richard E. Lee;Françoise Portaels;P. L. C. Small;P. L. C. Small

  • Novel Insights into the Mechanism of Inhibition of MmpL3, a Target of Multiple Pharmacophores in Mycobacterium tuberculosis

    Wei Li;Ashutosh Upadhyay;Fabio L. Fontes;E. Jeffrey North

  • Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux

    Richard E Lee;Julian G Hurdle;Jiuyu Liu;David F Bruhn

  • Acyl-Phosphates Initiate Membrane Phospholipid Synthesis in Gram-Positive Pathogens

    Ying-Jie Lu;Yong-Mei Zhang;Kimberly D. Grimes;Jianjun Qi

  • A Newly Discovered Mycobacterial Pathogen Isolated from Laboratory Colonies of Xenopus Species with Lethal Infections Produces a Novel Form of Mycolactone, the Mycobacterium ulcerans Macrolide Toxin

    Armand Mve-Obiang;Richard E. Lee;Edward S. Umstot;Kristin A. Trott

  • Inhibition of UDP-Gal Mutase and Mycobacterial Galactan Biosynthesis by Pyrrolidine Analogues of Galactofuranose

    Richard E Lee;Martin D. Smith;Robert J. Nash;Rhodri C. Griffiths

  • The structure-activity relationship of urea derivatives as anti-tuberculosis agents

    Joshua R. Brown;Elton J. North;Julian G. Hurdle;Christophe Morisseau

  • Chemical Knockout of Pantothenate Kinase Reveals the Metabolic and Genetic Program Responsible for Hepatic Coenzyme A Homeostasis

    Yong-Mei Zhang;Shigeru Chohnan;Kristopher G. Virga;Robert D. Stevens

  • Synthesis and Evaluation of Cyclic Secondary Amine Substituted Phenyl and Benzyl Nitrofuranyl Amides as Novel Antituberculosis Agents

    Rajendra P. Tangallapally;Raghunandan Yendapally;Robin E. Lee;and Anne J. M. Lenaerts

Frequent Co-Authors

Stephen W. White
Stephen W. White St. Jude Children's Research Hospital
Charles O. Rock
Charles O. Rock St. Jude Children's Research Hospital
Michael R. McNeil
Michael R. McNeil Colorado State University
Suzanne Jackowski
Suzanne Jackowski St. Jude Children's Research Hospital
Mary Jackson
Mary Jackson Colorado State University
Philip M. Potter
Philip M. Potter St. Jude Children's Research Hospital
Mary K. Danks
Mary K. Danks St. Jude Children's Research Hospital
Erik C. Böttger
Erik C. Böttger University of Zurich
Kim Lewis
Kim Lewis Northeastern University
Helena I. Boshoff
Helena I. Boshoff National Institutes of Health

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