Mary K. Danks

Overview

Best Publications

• Efficacy of topoisomerase I inhibitors, topotecan and irinotecan, administered at low dose levels in protracted schedules to mice bearing xenografts of human tumors

  Peter J. Houghton;Pamela J. Cheshire;James D. Hallman;Lois Lutz

  429
  Citations

• Stem and progenitor cell-mediated tumor selective gene therapy

  K S Aboody;J Najbauer;M K Danks

  365
  Citations

• Atypical multiple drug resistance in a human leukemic cell line selected for resistance to teniposide (VM-26).

  Mary K. Danks;Jack C. Yalowich;William T. Beck

  327
  Citations

• Altered catalytic activity of and DNA cleavage by DNA topoisomerase II from human leukemic cells selected for resistance to VM-26.

  Danks Mk;Schmidt Ca;Cirtain Mc;Suttle Dp

  326
  Citations

• Pharmacological, molecular, and cytogenetic analysis of "atypical" multidrug-resistant human leukemic cells.

  William T. Beck;M. C. Cirtain;M. K. Danks;R. L. Felsted

  247
  Citations

• Studies on the Mechanism of Resistance to Rapamycin in Human Cancer Cells

  Hajime Hosoi;Michael B. Dilling;Linda N. Liu;Mary K. Danks

  246
  Citations

• Proficient metabolism of irinotecan by a human intestinal carboxylesterase.

  Ruchi Khanna;Christopher L. Morton;Mary K. Danks;Philip M. Potter

  224
  Citations

• Structural insights into CPT-11 activation by mammalian carboxylesterases.

  Sompop Bencharit;Christopher L. Morton;Escher L. Howard-Williams;Mary K. Danks

  216
  Citations

• Expression of a mutant DNA topoisomerase II in CCRF-CEM human leukemic cells selected for resistance to teniposide.

  B Y Bugg;M K Danks;W T Beck;D P Suttle

  215
  Citations

• Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition.

  Sompop Bencharit;Christopher L Morton;Janice L Hyatt;Peter Kuhn

  201
  Citations

• Identification and Characterization of Novel Benzil (Diphenylethane-1,2-dione) Analogues as Inhibitors of Mammalian Carboxylesterases

  Randy M. Wadkins;Janice L. Hyatt;Xin Wei;Kyoung Jin P. Yoon

  194
  Citations

• Tumor-Targeted Enzyme/Prodrug Therapy Mediates Long-term Disease-Free Survival of Mice Bearing Disseminated Neuroblastoma

  Mary K. Danks;K. Jin Yoon;Rebecca A. Bush;Joanna S. Remack

  166
  Citations

• p53 mutation and MDM2 amplification frequency in pediatric rhabdomyosarcoma tumors and cell lines

  Alan C. Taylor;Lili Shu;Mary K. Danks;Catherine A. Poquette

  153
  Citations

• Comparison of activation of CPT-11 by rabbit and human carboxylesterases for use in enzyme/prodrug therapy.

  Mary K. Danks;Christopher L. Morton;Erik J. Krull;Pamela J. Cheshire

  152
  Citations

• Development of a tumor-selective approach to treat metastatic cancer.

  Karen S. Aboody;Rebecca A. Bush;Elizabeth Garcia;Marianne Z. Metz

  147
  Citations

• Brain tumor oncolysis with replication-conditional herpes simplex virus type 1 expressing the prodrug-activating genes, CYP2B1 and secreted human intestinal carboxylesterase, in combination with cyclophosphamide and irinotecan.

  Edyta Tyminski;Stanley LeRoy;Kinya Terada;Dianne M. Finkelstein

  143
  Citations

• Overexpression of a Rabbit Liver Carboxylesterase Sensitizes Human Tumor Cells to CPT-11

  Mary K. Danks;Christopher L. Morton;Cynthia A. Pawlik;Philip M. Potter

  140
  Citations

• The anticancer prodrug CPT-11 is a potent inhibitor of acetylcholinesterase but is rapidly catalyzed to SN-38 by butyrylcholinesterase.

  Christopher L. Morton;Randy M. Wadkins;Mary K. Danks;Philip M. Potter

  133
  Citations

• New therapeutic targets for the treatment of high-risk neuroblastoma.

  Lars M. Wagner;Mary K. Danks

  132
  Citations

• Discovery of Novel Selective Inhibitors of Human Intestinal Carboxylesterase for the Amelioration of Irinotecan-Induced Diarrhea: Synthesis, Quantitative Structure-Activity Relationship Analysis, and Biological Activity

  Randy M. Wadkins;Janice L Hyatt;Kyoung Jin P. Yoon;Christopher L. Morton

  130
  Citations