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Medicine

D-Index
87
Citations
23609
World Ranking
13777
National Ranking
6992

Overview

Clinton F. Stewart is affiliated with St. Jude Children's Research Hospital in the United States. Their research spans predominantly the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a notable focus on Oncology, Molecular Biology, and Genetics as subfields of study.

Their work addresses several specialized topics including:

  • Glioma Diagnosis and Treatment
  • Neuroblastoma Research and Treatments
  • Cancer therapeutics and mechanisms
  • Lung Cancer Research Studies
  • Protein Degradation and Inhibitors
  • Advanced Breast Cancer Therapies
  • Drug Transport and Resistance Mechanisms

Stewart has published extensively, with a substantial number of papers appearing in publication venues such as:

  • Neuro-Oncology (22 publications)
  • Cancer Research (4 publications)
  • Journal of Clinical Oncology (3 publications)
  • Journal of Chromatography B (3 publications)
  • Cancer Chemotherapy and Pharmacology (3 publications)

Some recent notable papers include:

  • Outcomes by Clinical and Molecular Features in Children With Medulloblastoma Treated With Risk-Adapted Therapy: Results of an International Phase III Trial (SJMB03), 2021, Journal of Clinical Oncology
  • Serial assessment of measurable residual disease in medulloblastoma liquid biopsies, 2021, Cancer Cell
  • A phase II trial of selumetinib in children with recurrent optic pathway and hypothalamic low-grade glioma without NF1: a Pediatric Brain Tumor Consortium study, 2021, Neuro-Oncology
  • A phase I trial of talazoparib and irinotecan with and without temozolomide in children and young adults with recurrent or refractory solid malignancies, 2020, European Journal of Cancer
  • Clinical Pharmacokinetics and Pharmacodynamics of Selumetinib, 2020, Clinical Pharmacokinetics

Frequent collaborators with Stewart include:

  • Olivia Campagne (34 joint publications)
  • Arzu Onar-Thomas (23 joint publications)
  • Amar Gajjar (20 joint publications)
  • Giles Robinson (18 joint publications)
  • Maryam Fouladi (15 joint publications)

Best Publications

  • Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial

    Amar Gajjar;Murali Chintagumpala;David Ashley;Stewart Kellie

  • Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.

    Justyna T. Romer;Hiromichi Kimura;Susan Magdaleno;Ken Sasai

  • Mrp4 confers resistance to topotecan and protects the brain from chemotherapy.

    Markos Leggas;Masashi Adachi;George L. Scheffer;Daxi Sun

  • Bevacizumab-Induced Transient Remodeling of the Vasculature in Neuroblastoma Xenografts Results in Improved Delivery and Efficacy of Systemically Administered Chemotherapy

    Paxton V. Dickson;John B. Hamner;Thomas L. Sims;Charles H. Fraga

  • Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog–Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032

    Giles W. Robinson;Brent A. Orr;Gang Wu;Sridharan Gururangan

  • Imatinib mesylate is a potent inhibitor of the ABCG2 (BCRP) transporter and reverses resistance to topotecan and SN-38 in vitro.

    Peter J. Houghton;Glen S. Germain;Franklin C. Harwood;John D. Schuetz

  • Selumetinib in paediatric patients with BRAF-aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade glioma: a multicentre, phase 2 trial.

    Jason Fangusaro;Arzu Onar-Thomas;Tina Young Poussaint;Shengjie Wu

  • Direct Translation of a Protracted Irinotecan Schedule From a Xenograft Model to a Phase I Trial in Children

    Wayne L. Furman;Clinton F. Stewart;Catherine A. Poquette;Charles B. Pratt

  • Medulloblastoma Genotype Dictates Blood Brain Barrier Phenotype.

    Timothy N. Phoenix;Deanna M. Patmore;Scott Boop;Nidal Boulos

  • A phase I trial of the MEK inhibitor selumetinib (AZD6244) in pediatric patients with recurrent or refractory low-grade glioma: a Pediatric Brain Tumor Consortium (PBTC) study

    Anuradha Banerjee;Regina I. Jakacki;Arzu Onar-Thomas;Shengjie Wu

  • Evaluation of 9-dimethylaminomethyl-10-hydroxycamptothecin against xenografts derived from adult and childhood solid tumors.

    Peter J. Houghton;Pamela J. Cheshire;Leann Myers;Clinton F. Stewart

  • A phase I/II trial of GW572016 (lapatinib) in recurrent glioblastoma multiforme: clinical outcomes, pharmacokinetics and molecular correlation

    Brian Thiessen;Clinton Stewart;Ming Tsao;Suzanne Kamel-Reid

  • Phase I Study of Vismodegib in Children with Recurrent or Refractory Medulloblastoma: A Pediatric Brain Tumor Consortium Study

    Amar Gajjar;Clinton F. Stewart;David W. Ellison;Sue Kaste

  • Gefitinib Enhances the Antitumor Activity and Oral Bioavailability of Irinotecan in Mice

    Clinton F. Stewart;Markos Leggas;John D. Schuetz;John C. Panetta

  • Phase I Study of Everolimus in Pediatric Patients With Refractory Solid Tumors

    Maryam Fouladi;Fred Laningham;Jianrong Wu;Melinda A. O'Shaughnessy

  • Crenolanib is active against models of drug-resistant FLT3-ITD−positive acute myeloid leukemia

    Eric I. Zimmerman;David C. Turner;Jassada Buaboonnam;Shuiying Hu

  • Pediatric Phase I Trial and Pharmacokinetic Study of Vorinostat: A Children's Oncology Group Phase I Consortium Report

    Maryam Fouladi;Julie R. Park;Clinton F. Stewart;Richard J. Gilbertson

  • Relationship between topotecan systemic exposure and tumor response in human neuroblastoma xenografts.

    William C. Zamboni;Clinton F. Stewart;Joyce Thompson;Victor M. Santana

  • Risk-adapted therapy for young children with medulloblastoma (SJYC07): therapeutic and molecular outcomes from a multicentre, phase 2 trial.

    Giles W Robinson;Vasilisa A Rudneva;Ivo Buchhalter;Catherine A Billups

  • Phase II Study of Irinotecan and Temozolomide in Children With Relapsed or Refractory Neuroblastoma: A Children's Oncology Group Study

    Rochelle Bagatell;Wendy B. London;Lars M. Wagner;Stephan D. Voss

Frequent Co-Authors

Amar Gajjar
Amar Gajjar St. Jude Children's Research Hospital
Richard J. Gilbertson
Richard J. Gilbertson University of Cambridge
Peter J. Houghton
Peter J. Houghton The University of Texas Health Science Center at San Antonio
Larry E. Kun
Larry E. Kun St. Jude Children's Research Hospital
James M. Boyett
James M. Boyett St. Jude Children's Research Hospital
Roger J. Packer
Roger J. Packer Children’s National Health System
Martine F. Roussel
Martine F. Roussel St. Jude Children's Research Hospital
William E. Evans
William E. Evans St. Jude Children's Research Hospital
Susan M. Blaney
Susan M. Blaney Baylor College of Medicine
Thomas E. Merchant
Thomas E. Merchant St. Jude Children's Research Hospital

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