John D. Schuetz

Overview

Best Publications

• The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype

  Sheng Zhou;John D. Schuetz;Kevin D. Bunting;Anne-Marie Colapietro

  2978
  Citations

• Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression.

  Peter Kuehl;Jiong Zhang;Yvonne Lin;Jatinder Lamba

  2669
  Citations

• Identification of functionally variant MDR1 alleles among European Americans and African Americans

  Richard B. Kim;Richard B. Kim;Brenda F. Leake;Brenda F. Leake;Edna F. Choo;Edna F. Choo;George K. Dresser;George K. Dresser

  1285
  Citations

• The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme.

  Partha Krishnamurthy;Douglas D. Ross;Douglas D. Ross;Takeo Nakanishi;Kim Bailey-Dell

  879
  Citations

• MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs.

  John D. Schuetz;Michele C. Connelly;Daxi Sun;Sheela G. Paibir

  731
  Citations

• Bcrp1 gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cells in vivo.

  Sheng Zhou;John J. Morris;Yuxiao Barnes;Lubin Lan

  715
  Citations

• Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes.

  Joseph C. Kolars;Phyllissa Schmiedlin-Ren;John D. Schuetz;Che Fang

  667
  Citations

• Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells.

  E G Schuetz;W T Beck;J D Schuetz

  652
  Citations

• Mrp4 confers resistance to topotecan and protects the brain from chemotherapy.

  Markos Leggas;Masashi Adachi;George L. Scheffer;Daxi Sun

  522
  Citations

• ROLE OF ABCG2/BCRP IN BIOLOGY AND MEDICINE

  Krishnamurthy P;Schuetz Jd

  468
  Citations

• Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration

  Rhonda M. Perciavalle;Daniel P. Stewart;Brian Koss;John Lynch

  447
  Citations

• Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450.

  Erin G. Schuetz;Stephen Strom;Kazuto Yasuda;Valerie Lecureur

  447
  Citations

• Imatinib mesylate is a potent inhibitor of the ABCG2 (BCRP) transporter and reverses resistance to topotecan and SN-38 in vitro.

  Peter J. Houghton;Glen S. Germain;Franklin C. Harwood;John D. Schuetz

  426
  Citations

• Identification of a mammalian mitochondrial porphyrin transporter

  Partha C. Krishnamurthy;Guoqing Du;Yu Fukuda;Daxi Sun

  425
  Citations

• High-affinity interaction of tyrosine kinase inhibitors with the ABCG2 multidrug transporter

  Csilla Ozvegy-Laczka;Tamás Hegedus;György Várady;Olga Ujhelly

  408
  Citations

• Transcriptional Control of Intestinal Cytochrome P-4503A by 1α,25-Dihydroxy Vitamin D3

  Kenneth E. Thummel;Cynthia Brimer;Kazuto Yasuda;Jaideep Thottassery

  389
  Citations

• A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase

  Eugene Y. Krynetski;John D. Schuetz;Amy J. Galpin;Ching-Hon Pui

  384
  Citations

• Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4)

  Noam Zelcer;Glen Reid;Peter Wielinga;Annemieke Kuil

  380
  Citations

• Selective expression of cytochrome P450 CYP3A mRNAs in embryonic and adult human liver.

  John D. Schuetz;Deborah L. Beach;Philip S. Guzelian

  372
  Citations

• Interindividual variation in expression of P-glycoprotein in normal human liver and secondary hepatic neoplasms.

  E G Schuetz;K N Furuya;J D Schuetz

  352
  Citations