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Genetics

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Molecular Biology

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Overview

Uwe Strähle is affiliated with the Karlsruhe Institute of Technology in Germany. Their research focuses primarily on biochemistry, genetics, and molecular biology, with particular emphasis on molecular biology, cell biology, cancer research, developmental neuroscience, and cellular and molecular neuroscience.

The scientist's work covers several key topics, including:

  • Zebrafish Biomedical Research Applications
  • MicroRNA in disease regulation
  • Neurogenesis and neuroplasticity mechanisms
  • Developmental Biology and Gene Regulation
  • Congenital heart defects research
  • Interferon and immune responses
  • Axon Guidance and Neuronal Signaling

Uwe Strähle has published extensively, with notable contributions to various publication venues. The most frequent outlets include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • OPAL (Open@LaTrobe) (La Trobe University)
  • Frontiers in Neuroscience
  • ACS Nano
  • EMBO Molecular Medicine

Among recent papers authored or co-authored by Uwe Strähle are:

  • "Common and Distinct Features of Adult Neurogenesis and Regeneration in the Telencephalon of Zebrafish and Mammals" (2020, Frontiers in Neuroscience)
  • "Differential Nanoparticle Sequestration by Macrophages and Scavenger Endothelial Cells Visualized in Vivo in Real-Time and at Ultrastructural Resolution" (2020, ACS Nano)
  • "Proteasome subunit PSMC3 variants cause neurosensory syndrome combining deafness and cataract due to proteotoxic stress" (2020, EMBO Molecular Medicine)
  • "Pax6 organizes the anterior eye segment by guiding two distinct neural crest waves" (2020, PLoS Genetics)
  • "Loss of the Bardet-Biedl protein Bbs1 alters photoreceptor outer segment protein and lipid composition" (2022, Nature Communications)

The scientist collaborates frequently with other researchers, including:

  • Masanari Takamiya
  • Sepand Rastegar
  • Victor Gourain
  • Thomas Dickmeis
  • Luisa Lübke

Best Publications

  • Cooperativity of glucocorticoid response elements located far upstream of the tyrosine aminotransferase gene.

    Hans Michael Jantzen;Uwe Strähle;Bernd Gloss;Francis Stewart

  • Zebrafish embryos as an alternative to animal experiments--a commentary on the definition of the onset of protected life stages in animal welfare regulations.

    Uwe Strähle;Stefan Scholz;Robert Geisler;Petra Greiner

  • A DNA sequence of 15 base pairs is sufficient to mediate both glucocorticoid and progesterone induction of gene expression

    U Strähle;G Klock;G Schütz

  • Synergistic action of the glucocorticoid receptor with transcription factors.

    U. Strähle;W. Schmid;Günther Schütz

  • Acetylcholinesterase is required for neuronal and muscular development in the zebrafish embryo

    Martine Behra;Xavier Cousin;Christelle Bertrand;Jean-Luc Vonesch

  • Conserved and acquired features of adult neurogenesis in the zebrafish telencephalon

    Birgit Adolf;Prisca Chapouton;Chen Sok Lam;Stefanie Topp

  • Oestrogen and glucocorticoid responsive elements are closely related but distinct

    Gerd Klock;Uwe Strähle;Günther Schütz

  • Zebrafish Clock rhythmic expression reveals independent peripheral circadian oscillators

    David Whitmore;Nicholas S. Foulkes;Uwe Strähle;Paolo Sassone-Corsi

  • Neurogenesis in zebrafish – from embryo to adult

    Rebecca Schmidt;Uwe Strähle;Steffen Scholpp

  • In vivo protein-DNA interactions in a glucocorticoid response element require the presence of the hormone

    Peter B. Becker;Bernd Gloss;Wolfgang Schmid;Uwe Strähle

  • Zebrafish embryos as models for embryotoxic and teratological effects of chemicals

    Lixin Yang;Nga Yu Ho;Rüdiger Alshut;Jessica Legradi

  • Toxicity of mercury: Molecular evidence.

    Lixin Yang;Yuanyuan Zhang;Feifei Wang;Zidie Luo

  • Axial, a zebrafish gene expressed along the developing body axis, shows altered expression in cyclops mutant embryos.

    U Strähle;P Blader;D Henrique;P W Ingham

  • Heterogeneity in progenitor cell subtypes in the ventricular zone of the zebrafish adult telencephalon.

    Martin März;Prisca Chapouton;Nicolas Diotel;Colette Vaillant

  • The activity of neurogenin1 is controlled by local cues in the zebrafish embryo

    Patrick Blader;Nadine Fischer;Gerard Gradwohl;François Guillemot

  • gfap and nestin reporter lines reveal characteristics of neural progenitors in the adult zebrafish brain

    Chen Sok Lam;Martin März;Uwe Strähle

  • WNT5 Is Required for Tail Formation in the Zebrafish Embryo

    G.-J. Rauch;M. Hammerschmidt;P. Blader;H.E. Schauerte

  • Cleavage of the BMP-4 Antagonist Chordin by Zebrafish Tolloid

    Patrick Blader;Sepand Rastegar;Nadine Fischer;Uwe Strähle

  • Two independent transcription initiation codes overlap on vertebrate core promoters

    Vanja Haberle;Vanja Haberle;Nan Li;Yavor Hadzhiev;Charles Plessy

  • Dynamic microtubules and specification of the zebrafish embryonic axis

    Suresh Jesuthasan;Uwe Strähle

Frequent Co-Authors

Ralf Mikut
Ralf Mikut Karlsruhe Institute of Technology
G. Ulrich Nienhaus
G. Ulrich Nienhaus Karlsruhe Institute of Technology
Henner Hollert
Henner Hollert Goethe University Frankfurt
Vladimir Korzh
Vladimir Korzh United Way
Hélène Dollfus
Hélène Dollfus University of Strasbourg
Philip W. Ingham
Philip W. Ingham University of Bath
Günther Schütz
Günther Schütz German Cancer Research Center
Laure Bally-Cuif
Laure Bally-Cuif Institut Pasteur
Thomas Braunbeck
Thomas Braunbeck Heidelberg University
Boris Lenhard
Boris Lenhard Imperial College London

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