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Molecular Biology

D-Index
65
Citations
21740
World Ranking
1648
National Ranking
834

Overview

Xavier Darzacq is affiliated with the University of California, Berkeley, in the United States. Their research primarily falls within the field of Biochemistry, Genetics, and Molecular Biology, with a specialization in Molecular Biology, Biophysics, Biomedical Engineering, Plant Science, and Infectious Diseases.

The scientist's work covers several main topics, including:

  • Genomics and Chromatin Dynamics
  • Advanced Fluorescence Microscopy Techniques
  • RNA Research and Splicing
  • Single-cell and spatial transcriptomics
  • Protein Degradation and Inhibitors
  • Cell Image Analysis Techniques
  • CRISPR and Genetic Engineering

The frequent co-authors collaborating with Xavier Darzacq include Robert Tjian, Gina M. Dailey, Thomas G.W. Graham, Claire Dugast-Darzacq, and Alec Heckert.

The researcher has published notably in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • eLife
  • Molecular Cell
  • Zenodo (CERN European Organization for Nuclear Research)
  • RNA

Selected recent publications by Xavier Darzacq include:

  • Resolving the 3D Landscape of Transcription-Linked Mammalian Chromatin Folding, 2020, Molecular Cell
  • Overcoming the bottleneck to widespread testing: a rapid review of nucleic acid testing approaches for COVID-19 detection, 2020, RNA
  • Enhancer-promoter interactions and transcription are largely maintained upon acute loss of CTCF, cohesin, WAPL or YY1, 2022, Nature Genetics
  • Tuning levels of low-complexity domain interactions to modulate endogenous oncogenic transcription, 2022, Molecular Cell
  • The transcription factor activity gradient (TAG) model: contemplating a contact-independent mechanism for enhancer-promoter communication, 2021, Genes & Development

Best Publications

  • Phase Separation Drives Heterochromatin Domain Formation

    Amy R. Strom;Alexander V. Emelyanov;Mustafa R. Mir;Dmitry V. Fyodorov

  • Imaging dynamic and selective low-complexity domain interactions that control gene transcription

    Shasha Chong;Claire Dugast-Darzacq;Zhe Liu;Peng Dong

  • In vivo dynamics of RNA polymerase II transcription

    Xavier Darzacq;Yaron Shav-Tal;Yaron Shav-Tal;Valeria de Turris;Yehuda Brody

  • Cajal body-specific small nuclear RNAs: a novel class of 2'-O-methylation and pseudouridylation guide RNAs.

    Xavier Darzacq;Beáta E. Jády;Céline Verheggen;Arnold M. Kiss

  • RNA polymerase II clustering through carboxy-terminal domain phase separation

    Marc Boehning;Claire Dugast-Darzacq;Marija Rankovic;Anders S Hansen

  • CTCF and cohesin regulate chromatin loop stability with distinct dynamics

    Anders S Hansen;Iryna Pustova;Claudia Cattoglio;Robert Tjian

  • Dynamics of Single mRNPs in Nuclei of Living Cells

    Yaron Shav-Tal;Xavier Darzacq;Shailesh M. Shenoy;Dahlene Fusco

  • Resolving the 3D Landscape of Transcription-Linked Mammalian Chromatin Folding.

    Tsung-Han S. Hsieh;Claudia Cattoglio;Elena Slobodyanyuk;Anders S. Hansen

  • Real-Time Dynamics of RNA Polymerase II Clustering in Live Human Cells

    Ibrahim I. Cisse;Ibrahim I. Cisse;Ignacio Izeddin;Sebastien Z. Causse;Lydia Boudarene

  • Phase-separation mechanism for C-terminal hyperphosphorylation of RNA polymerase II.

    Huasong Lu;Huasong Lu;Dan Yu;Anders S. Hansen;Sourav Ganguly

  • Fast multicolor 3D imaging using aberration-corrected multifocus microscopy

    Sara Abrahamsson;Sara Abrahamsson;Sara Abrahamsson;Jiji Chen;Bassam Hajj;Sjoerd Stallinga

  • Evaluating phase separation in live cells: diagnosis, caveats, and functional consequences

    David T. McSwiggen;Mustafa Mir;Xavier Darzacq;Robert Tjian

  • Overcoming the bottleneck to widespread testing: a rapid review of nucleic acid testing approaches for COVID-19 detection.

    Meagan N. Esbin;Oscar N. Whitney;Shasha Chong;Anna Maurer

  • Dynamic Sorting of Nuclear Components into Distinct Nucleolar Caps during Transcriptional Inhibition

    Yaron Shav-Tal;Janna Blechman;Xavier Darzacq;Cristina Montagna

  • FISH-quant: automatic counting of transcripts in 3D FISH images

    Florian Mueller;Florian Mueller;Adrien Senecal;Katjana Tantale;Hervé Marie-Nelly

  • A transgenic mouse for in vivo detection of endogenous labeled mRNA

    Timothée Lionnet;Kevin Czaplinski;Xavier Darzacq;Yaron Shav-Tal

  • Gene Expression Is Circular: Factors for mRNA Degradation Also Foster mRNA Synthesis

    Gal Haimovich;Daniel A. Medina;Sebastien Z. Causse;Manuel Garber

  • Single-molecule tracking in live cells reveals distinct target-search strategies of transcription factors in the nucleus

    Ignacio Izeddin;Vincent Récamier;Lana Bosanac;Lana Bosanac;Ibrahim I Cissé

  • Modification of Sm small nuclear RNAs occurs in the nucleoplasmic Cajal body following import from the cytoplasm

    Beáta E. Jády;Xavier Darzacq;Karen E. Tucker;A. Gregory Matera

  • Transcription Factors Modulate c-Fos Transcriptional Bursts

    Adrien Senecal;Brian Munsky;Florence Proux;Nathalie Ly

Frequent Co-Authors

Robert Tjian
Robert Tjian University of California, Berkeley
Robert H. Singer
Robert H. Singer Albert Einstein College of Medicine
Edouard Bertrand
Edouard Bertrand Centre national de la recherche scientifique, CNRS
Antoine Triller
Antoine Triller École Normale Supérieure
Olivier Bensaude
Olivier Bensaude École Normale Supérieure
Michael R. Botchan
Michael R. Botchan University of California, Berkeley
Carl Wu
Carl Wu Johns Hopkins University
James M. Berger
James M. Berger Johns Hopkins University
Job Dekker
Job Dekker University of Massachusetts Chan Medical School
Carlos Bustamante
Carlos Bustamante Stanford University

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