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Leonid A. Mirny

Leonid A. Mirny

D-Index & Metrics

Genetics

D-Index
89
Citations
51053
World Ranking
1095
National Ranking
528

Research.com Recognitions

  • 2014 - Fellow of American Physical Society (APS) Citation For elucidating principles of proteinDNA search, and for applying concepts and methods of polymer physics to characterize the three dimensional organization of genome within a cell
  • 2003 - Fellow of Alfred P. Sloan Foundation

Overview

Leonid A. Mirny is primarily affiliated with the Massachusetts Institute of Technology (MIT) in the United States. Their research spans a broad range of topics within biochemistry, genetics, and molecular biology, with a particular focus on molecular biology. The scientist has contributed substantially to the understanding of genomics and chromatin dynamics, RNA research and splicing, cancer genomics and diagnostics, gene expression and cancer classification, RNA and protein synthesis mechanisms, chromosomal and genetic variations, and epigenetics and DNA methylation.

Recent notable papers authored by Mirny include:

  • Ultrastructural Details of Mammalian Chromosome Architecture, 2020, Molecular Cell
  • Dynamics of CTCF- and cohesin-mediated chromatin looping revealed by live-cell imaging, 2022, Science
  • Systematic evaluation of chromosome conformation capture assays, 2021, Nature Methods
  • Transcription shapes 3D chromatin organization by interacting with loop extrusion, 2023, Proceedings of the National Academy of Sciences
  • Molecular basis of CTCF binding polarity in genome folding, 2020, Nature Communications

Frequent co-authors collaborating with Mirny include:

  • Edward J. Banigan
  • Simon Grosse-Holz
  • Antoine Coulon
  • Daniele Fachinetti
  • Maxime Dahan

Their work is regularly published in venues such as:

  • Zenodo (CERN European Organization for Nuclear Research)
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Structural & Molecular Biology
  • Science
  • Nature Communications

Leonid A. Mirny's research integrates approaches from biophysics and molecular biology to investigate chromatin architecture and gene regulation processes. The scientist's research topics highlight significant intersections between genomics, chromatin dynamics, and cancer-related studies within molecular biology.

Among recognized distinctions, Mirny is a Fellow of the American Physical Society (APS), awarded in 2014 for elucidating principles of protein-DNA interactions and applying polymer physics concepts to characterize the 3D organization of the genome within cells. Mirny is also a Fellow of the Alfred P. Sloan Foundation since 2003.

Best Publications

  • Comprehensive mapping of long-range interactions reveals folding principles of the human genome.

    Erez Lieberman-Aiden;Nynke L. van Berkum;Louise Williams;Maxim Imakaev

  • HiGlass: web-based visual exploration and analysis of genome interaction maps

    Peter Kerpedjiev;Nezar Abdennur;Fritz Lekschas;Chuck McCallum

  • Formation of Chromosomal Domains by Loop Extrusion

    Geoffrey Fudenberg;Maksim Viktorovich Imakaev;Carolyn Lu;Anton Goloborodko

  • Protein complexes and functional modules in molecular networks

    Victor Spirin;Leonid A. Mirny

  • Targeted Degradation of CTCF Decouples Local Insulation of Chromosome Domains from Genomic Compartmentalization.

    Elphège P. Nora;Anton Goloborodko;Anne-Laure Valton;Johan H. Gibcus

  • Iterative correction of Hi-C data reveals hallmarks of chromosome organization

    Maxim Imakaev;Geoffrey Fudenberg;Rachel Patton McCord;Natalia Naumova

  • Cooler: scalable storage for Hi-C data and other genomically labeled arrays.

    Nezar Abdennur;Leonid A Mirny

  • Exploring the three-dimensional organization of genomes: interpreting chromatin interaction data

    Job Dekker;Marc A. Marti-Renom;Leonid A. Mirny

  • Two independent modes of chromatin organization revealed by cohesin removal

    Wibke Schwarzer;Nezar Abdennur;Anton Goloborodko;Aleksandra Pekowska

  • Organization of the Mitotic Chromosome

    Natalia Naumova;Maxim Imakaev;Geoffrey Fudenberg;Geoffrey Fudenberg;Ye Zhan

  • The 3D Genome as Moderator of Chromosomal Communication

    Job Dekker;Leonid A. Mirny

  • Super-resolution imaging reveals distinct chromatin folding for different epigenetic states

    Alistair N. Boettiger;Bogdan Bintu;Jeffrey R. Moffitt;Siyuan Wang

  • Single-nucleus Hi-C reveals unique chromatin reorganization at oocyte-to-zygote transition

    Ilya M. Flyamer;Johanna Gassler;Maxim Imakaev;Hugo B. Brandão

  • A pathway for mitotic chromosome formation

    Johan H. Gibcus;Kumiko Samejima;Anton Goloborodko;Itaru Samejima

  • The 4D nucleome project

    Job Dekker;Andrew S. Belmont;Mitchell Guttman;Victor O. Leshyk

  • The fractal globule as a model of chromatin architecture in the cell

    Leonid A. Mirny

  • High-Resolution Mapping of the Spatial Organization of a Bacterial Chromosome

    Tung Ba Khanh Le;Maksim Viktorovich Imakaev;Leonid A. Mirny;Michael T. Laub;Michael T. Laub

  • Chromatin organization by an interplay of loop extrusion and compartmental segregation

    Johannes Nuebler;Geoffrey Fudenberg;Maxim Imakaev;Nezar Abdennur

  • Kinetics of Protein-DNA Interaction: Facilitated Target Location in Sequence-Dependent Potential

    Michael Slutsky;Leonid A. Mirny

  • Super-resolution imaging reveals distinct chromatin folding for different epigenetic states

    Alistair N. Boettiger;Bogdan Bintu;Jeffrey R. Moffitt;Siyuan Wang

Frequent Co-Authors

Job Dekker
Job Dekker University of Massachusetts Chan Medical School
Eugene I. Shakhnovich
Eugene I. Shakhnovich Harvard University
John F. Marko
John F. Marko Northwestern University
Bryan R. Lajoie
Bryan R. Lajoie University of Massachusetts Chan Medical School
Mikhail S. Gelfand
Mikhail S. Gelfand Skolkovo Institute of Science and Technology
Boris Reizis
Boris Reizis New York University
Antoine M. van Oijen
Antoine M. van Oijen Illawarra Health and Medical Research Institute
Peter J. Park
Peter J. Park Harvard University
Benoit G. Bruneau
Benoit G. Bruneau Gladstone Institutes

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