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Eugene I. Shakhnovich

Eugene I. Shakhnovich

Harvard University
United States

D-Index & Metrics

Chemistry

D-Index
87
Citations
28505
World Ranking
2396
National Ranking
847

Eugene I. Shakhnovich publication distribution in Chemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Chemistry in 2026. The highlighted bar marks where Eugene I. Shakhnovich sits on this spectrum.

61–80 publications: 66 scientists 81–100 publications: 302 scientists 101–120 publications: 623 scientists 121–140 publications: 918 scientists 141–160 publications: 1,218 scientists 161–180 publications: 1,350 scientists 181–200 publications: 1,344 scientists 201–220 publications: 1,281 scientists 221–240 publications: 1,216 scientists 241–260 publications: 1,100 scientists 261–280 publications: 979 scientists 281–300 publications: 939 scientists 301–320 publications: 764 scientists 321–340 publications: 643 scientists 341–360 publications: 628 scientists 361–380 publications: 522 scientists 381–400 publications: 459 scientists 401–420 publications: 397 scientists 421–440 publications: 327 scientists 441–460 publications: 270 scientists 461–480 publications: 265 scientists 481–500 publications: 252 scientists 501–520 publications: 201 scientists 521–540 publications: 185 scientists 541–560 publications: 148 scientists 561–580 publications: 148 scientists 581–600 publications: 132 scientists 601–620 publications: 114 scientists 621–640 publications: 104 scientists 641–660 publications: 91 scientists 661–680 publications: 92 scientists 681–700 publications: 73 scientists 701–720 publications: 57 scientists 721–740 publications: 54 scientists 741–760 publications: 67 scientists 761–780 publications: 45 scientists 781–800 publications: 46 scientists 801–820 publications: 39 scientists 821–840 publications: 32 scientists 841–860 publications: 36 scientists 861–880 publications: 29 scientists 881–900 publications: 26 scientists 901–920 publications: 24 scientists 921–940 publications: 14 scientists 941–960 publications: 23 scientists 961–980 publications: 28 scientists 981–1,000 publications: 15 scientists 1,001–1,020 publications: 29 scientists 1,021–1,040 publications: 12 scientists 1,041–1,060 publications: 19 scientists 1,061–1,080 publications: 12 scientists 1,081–1,100 publications: 6 scientists 1,101–1,120 publications: 8 scientists 1,121–1,140 publications: 12 scientists 1,141–1,160 publications: 5 scientists 1,161–1,180 publications: 6 scientists 1,181–1,200 publications: 14 scientists 1,201–1,220 publications: 7 scientists 1,221–1,240 publications: 2 scientists 1,241–1,260 publications: 6 scientists 1,261–1,280 publications: 4 scientists 1,281–1,294 publications: 6 scientists 1,295+ publications: 100 scientists
61 publications 1,295+

This scientist: 363 publications — 75th percentile

75% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,295 publications or more.

Eugene I. Shakhnovich D-index placement in Chemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Chemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Eugene I. Shakhnovich sits on this spectrum.

40–41 D-Index: 289 scientists 42–43 D-Index: 612 scientists 44–45 D-Index: 808 scientists 46–47 D-Index: 776 scientists 48–49 D-Index: 835 scientists 50–51 D-Index: 861 scientists 52–53 D-Index: 872 scientists 54–55 D-Index: 933 scientists 56–57 D-Index: 1,051 scientists 58–59 D-Index: 930 scientists 60–61 D-Index: 882 scientists 62–63 D-Index: 834 scientists 64–65 D-Index: 731 scientists 66–67 D-Index: 775 scientists 68–69 D-Index: 683 scientists 70–71 D-Index: 646 scientists 72–73 D-Index: 561 scientists 74–75 D-Index: 501 scientists 76–77 D-Index: 437 scientists 78–79 D-Index: 388 scientists 80–81 D-Index: 354 scientists 82–83 D-Index: 292 scientists 84–85 D-Index: 275 scientists 86–87 D-Index: 254 scientists 88–89 D-Index: 235 scientists 90–91 D-Index: 185 scientists 92–93 D-Index: 192 scientists 94–95 D-Index: 155 scientists 96–97 D-Index: 163 scientists 98–99 D-Index: 125 scientists 100–101 D-Index: 105 scientists 102–103 D-Index: 105 scientists 104–105 D-Index: 112 scientists 106–107 D-Index: 88 scientists 108–109 D-Index: 68 scientists 110–111 D-Index: 69 scientists 112–113 D-Index: 65 scientists 114–115 D-Index: 79 scientists 116–117 D-Index: 61 scientists 118–119 D-Index: 44 scientists 120–121 D-Index: 37 scientists 122–123 D-Index: 40 scientists 124–125 D-Index: 33 scientists 126–127 D-Index: 26 scientists 128–129 D-Index: 34 scientists 130–131 D-Index: 35 scientists 132–133 D-Index: 25 scientists 134–135 D-Index: 27 scientists 136–137 D-Index: 17 scientists 138–139 D-Index: 16 scientists 140–141 D-Index: 20 scientists 142–143 D-Index: 20 scientists 144–145 D-Index: 15 scientists 146–147 D-Index: 9 scientists 148–149 D-Index: 9 scientists 150–151 D-Index: 16 scientists 152–153 D-Index: 11 scientists 154–155 D-Index: 9 scientists 156–157 D-Index: 3 scientists 158 D-Index: 3 scientists 159+ D-Index: 98 scientists
40 D-Index 159+

This scientist: 87 D-Index — 87th percentile

87% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 159 D-Index or more.

Research.com Recognitions

  • 2015 - Fellow of American Physical Society (APS) Citation For seminal contributions to the statistical physics of polypeptides, by significantly extending methods previously used for disordered systems, and for discovery of physicalchemical principles of selection of protein sequences now used as a tool for discovery of new protein sequences

Overview

Eugene I. Shakhnovich is affiliated with Harvard University in the United States. Their research primarily spans the field of Biochemistry, Genetics and Molecular Biology, with a significant focus on Molecular Biology, Materials Chemistry, Genetics, Infectious Diseases, and Computational Theory and Mathematics.

Their scholarly work covers a range of topics, notably:

  • Protein Structure and Dynamics
  • RNA and protein synthesis mechanisms
  • RNA Research and Splicing
  • Enzyme Structure and Function
  • Connexins and lens biology
  • Evolution and Genetic Dynamics
  • RNA modifications and cancer

Shakhnovich has contributed extensively to scientific literature with frequent publications in several venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Biophysical Journal
  • arXiv (Cornell University)
  • Proceedings of the National Academy of Sciences
  • Nature Communications

Recent notable papers include:

  • "Dynamic metastable long-living droplets formed by sticker-spacer proteins" (2020, eLife)
  • "Cotranslational folding allows misfolding-prone proteins to circumvent deep kinetic traps" (2020, Proceedings of the National Academy of Sciences)
  • "The physics of liquid-to-solid transitions in multi-domain protein condensates" (2022, Biophysical Journal)
  • "Thermal Half-Lives of Azobenzene Derivatives: Virtual Screening Based on Intersystem Crossing Using a Machine Learning Potential" (2023, ACS Central Science)
  • "Phosphorylation sites are evolutionary checkpoints against liquid-solid transition in protein condensates" (2023, Proceedings of the National Academy of Sciences)

Frequent collaborators in Shakhnovich's research include Eugene Serebryany, Srivastav Ranganathan, D. I. C. Wang, Amir Bitran, and Sourav Chowdhury.

In recognition of their work, Eugene I. Shakhnovich was named a Fellow of the American Physical Society (APS) in 2015. The citation highlighted contributions to the statistical physics of polypeptides, advancement of methods for disordered systems, and discoveries related to physical-chemical principles guiding protein sequence selection.

Best Publications

  • How does a protein fold

    Andrej Šali;Eugene Shakhnovich;Martin Karplus

  • Kinetics of protein folding. A lattice model study of the requirements for folding to the native state.

    Andrej Šali;Eugene Shakhnovich;Martin Karplus

  • Engineering of stable and fast-folding sequences of model proteins

    E I Shakhnovich;A M Gutin

  • Specific nucleus as the transition state for protein folding: evidence from the lattice model.

    V. I. Abkevich;A. M. Gutin;E. I. Shakhnovich

  • Common activation mechanism of class A GPCRs.

    Qingtong Zhou;Dehua Yang;Meng Wu;Meng Wu;Yu Guo;Yu Guo

  • On the transition coordinate for protein folding

    Rose Du;Vijay S. Pande;Vijay S. Pande;Alexander Yu. Grosberg;Toyoichi Tanaka

  • The role of topological constraints in the kinetics of collapse of macromolecules

    A. Yu. Grosberg;S.K. Nechaev;E.I. Shakhnovich

  • Theoretical studies of protein-folding thermodynamics and kinetics.

    Eugene I Shakhnovich

  • Proteins with selected sequences fold into unique native conformation.

    Shakhnovich Ei

  • Estimating the Entropic Cost of Self-Assembly of Multiparticle Hydrogen-Bonded Aggregates Based on the Cyanuric Acid·Melamine Lattice

    Mathai Mammen;Eugene I. Shakhnovich;John M. Deutch;George M. Whitesides

  • Conserved residues and the mechanism of protein folding

    E. Shakhnovich;V. Abkevich;O. Ptitsyn

  • Universally conserved positions in protein folds: reading evolutionary signals about stability, folding kinetics and function.

    Leonid A. Mirny;Eugene I. Shakhnovich

  • Protein folding theory: from lattice to all-atom models.

    Leonid Mirny;Eugene Shakhnovich

  • Protein Folding Thermodynamics and Dynamics: Where Physics, Chemistry, and Biology Meet

    Eugene I Shakhnovich

  • Formation of unique structure in polypeptide chains theoretical investigation with the aid of a replica approach

    E.I. Shakhnovich;A.M. Gutin

  • SMoG: de Novo Design Method Based on Simple, Fast, and Accurate Free Energy Estimates. 1. Methodology and Supporting Evidence

    Robert S. DeWitte;Eugene I. Shakhnovich

  • Discrete molecular dynamics studies of the folding of a protein-like model.

    Nikolay V. Dokholyan;Sergey V. Buldyrev;H Eugene Stanley;Eugene I. Shakhnovich

  • Impact of local and non-local interactions on thermodynamics and kinetics of protein folding.

    V.I. Abkevich;A.M. Gutin;E.I. Shakhnovich

  • Protein folding bottlenecks: A lattice Monte Carlo simulation.

    E. Shakhnovich;G. Farztdinov;A. M. Gutin;M. Karplus

  • Topological determinants of protein folding

    Nikolay V. Dokholyan;Lewyn Li;Feng Ding;Eugene I. Shakhnovich

  • Implications of thermodynamics of protein folding for evolution of primary sequences.

    E. I. Shakhnovich;E. I. Shakhnovich;A. M. Gutin

  • How to derive a protein folding potential? A new approach to an old problem.

    Leonid A. Mirny;Eugene I. Shakhnovich

Frequent Co-Authors

Nikolay V. Dokholyan
Nikolay V. Dokholyan Pennsylvania State University
Leonid A. Mirny
Leonid A. Mirny MIT
Arup K. Chakraborty
Arup K. Chakraborty MIT
Sergey V. Buldyrev
Sergey V. Buldyrev Yeshiva University
Martin Karplus
Martin Karplus Harvard University
H. Eugene Stanley
H. Eugene Stanley Boston University
Feng Ding
Feng Ding Clemson University
Ricardo A. Broglia
Ricardo A. Broglia University of Milan
Andrej Sali
Andrej Sali University of California, San Francisco
George M. Whitesides
George M. Whitesides Harvard University

External Links

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Related Online Degrees & Career Pathways

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Best Scientists Citing Eugene I. Shakhnovich

Nikolay V. Dokholyan

Nikolay V. Dokholyan

Pennsylvania State University

Publications: 140

José N. Onuchic

José N. Onuchic

Rice University

Publications: 93

Peter G. Wolynes

Peter G. Wolynes

Rice University

Publications: 82

Martin Karplus

Martin Karplus

Harvard University

Publications: 76

Vijay S. Pande

Vijay S. Pande

Stanford University

Publications: 68

Jeffrey Skolnick

Jeffrey Skolnick

Georgia Institute of Technology

Publications: 68

Hue Sun Chan

Hue Sun Chan

University of Toronto

Publications: 64

Feng Ding

Feng Ding

Clemson University

Publications: 64

Claus O. Wilke

Claus O. Wilke

The University of Texas at Austin

Publications: 62

Michele Vendruscolo

Michele Vendruscolo

University of Cambridge

Publications: 59

Arup K. Chakraborty

Arup K. Chakraborty

MIT

Publications: 56

Ruth Nussinov

Ruth Nussinov

National Institutes of Health

Publications: 54

Jin Wang

Jin Wang

Stony Brook University

Publications: 51

Harold A. Scheraga

Harold A. Scheraga

Cornell University

Publications: 51

Andrzej Kolinski

Andrzej Kolinski

University of Warsaw

Publications: 48

Ricardo A. Broglia

Ricardo A. Broglia

University of Milan

Publications: 47

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