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José N. Onuchic

José N. Onuchic

D-Index & Metrics

Chemistry

D-Index
107
Citations
46574
World Ranking
899
National Ranking
357

Research.com Recognitions

  • 2019 - Max Delbruck Prize, Division of Biological Physics of the American Physical Society For independent contributions to a new view of protein folding, from the introduction and exploration of simple models, to detailed confrontations between theory and experiment.
  • 2017 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2009 - Fellow of the American Academy of Arts and Sciences
  • 2006 - Member of the National Academy of Sciences
  • 1995 - Fellow of American Physical Society (APS) Citation For advancing our understanding of electron transfer in complex molecules

Overview

José N. Onuchic is affiliated with Rice University in the United States and has made significant contributions in the fields of biochemistry, genetics, and molecular biology. Their research encompasses major subfields including molecular biology, cancer research, cell biology, plant science, and immunology.

Their main research topics cover a broad range of areas:

  • Genomics and Chromatin Dynamics
  • RNA and protein synthesis mechanisms
  • Protein Structure and Dynamics
  • Cancer, Hypoxia, and Metabolism
  • Chromosomal and Genetic Variations
  • RNA Research and Splicing
  • Microtubule and mitosis dynamics

Recent publications reflect a focus on genomics, cancer biology, and molecular mechanisms:

  • "3D genomics across the tree of life reveals condensin II as a determinant of architecture type" (2021) published in Science
  • "Enhancing intracellular accumulation and target engagement of PROTACs with reversible covalent chemistry" (2020) published in Nature Communications
  • "Decoding leader cells in collective cancer invasion" (2021) published in Nature reviews. Cancer
  • "Towards decoding the coupled decision-making of metabolism and epithelial-to-mesenchymal transition in cancer" (2021) published in British Journal of Cancer
  • "Exploring chromosomal structural heterogeneity across multiple cell lines" (2020) published in eLife

Frequent collaborators in their research include:

  • Vinícius G. Contessoto
  • Herbert Levine
  • Antonio B. Oliveira
  • Dongya Jia
  • Esteban Dodero-Rojas

Onuchic's work has appeared in notable publication venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Proceedings of the National Academy of Sciences
  • Biophysical Journal
  • arXiv (Cornell University)
  • The Journal of Physical Chemistry B

Their achievements have been recognized through several awards and honors:

  • Max Delbruck Prize, Division of Biological Physics of the American Physical Society (2019) - for contributions to protein folding theory and experiment
  • Fellow of the American Association for the Advancement of Science (AAAS) (2017)
  • Fellow of the American Academy of Arts and Sciences (2009)
  • Member of the National Academy of Sciences (2006)
  • Fellow of American Physical Society (APS) (1995) - for advancing understanding of electron transfer in complex molecules

Best Publications

  • Funnels, pathways, and the energy landscape of protein folding: A synthesis

    Joseph D. Bryngelson;José Nelson Onuchic;Nicholas D. Socci;Peter G. Wolynes

  • THEORY OF PROTEIN FOLDING: The Energy Landscape Perspective

    José Nelson Onuchic;Zaida Luthey-Schulten;Peter G. Wolynes

  • Topological and energetic factors: what determines the structural details of the transition state ensemble and "en-route" intermediates for protein folding? An investigation for small globular proteins

    Cecilia Clementi;Hugh Nymeyer;José Nelson Onuchic

  • Theory of protein folding.

    José Nelson Onuchic;Peter G Wolynes

  • Navigating the folding routes.

    Peter G. Wolynes;Jose N. Onuchic;D. Thirumalai

  • WATER MEDIATION IN PROTEIN FOLDING AND MOLECULAR RECOGNITION

    Yaakov Levy;José N. Onuchic

  • Protein folding funnels: a kinetic approach to the sequence-structure relationship.

    Peter E. Leopold;Mauricio Montal;Jose Nelson Onuchic

  • Protein electron transfer rates set by the bridging secondary and tertiary structure

    D. N. Beratan;J. N. Betts;J. N. Onuchic

  • Effect of friction on electron transfer in biomolecules

    Anupam Garg;Anupam Garg;José Nelson Onuchic;José Nelson Onuchic;Vinay Ambegaokar;Vinay Ambegaokar

  • Toward an outline of the topography of a realistic protein-folding funnel

    J. N. Onuchic;P. G. Wolynes;Z. Luthey-Schulten;N. D. Socci

  • Electron-tunneling pathways in proteins.

    David N. Beratan;José Nelson Onuchic;Jay R. Winkler;Harry B. Gray

  • Protein folding mediated by solvation: Water expulsion and formation of the hydrophobic core occur after the structural collapse

    Margaret S. Cheung;Angel E. García;José N. Onuchic

  • Nonlinear elasticity, proteinquakes, and the energy landscapes of functional transitions in proteins

    O. Miyashita;J. N. Onuchic;P. G. Wolynes

  • DIFFUSIVE DYNAMICS OF THE REACTION COORDINATE FOR PROTEIN FOLDING FUNNELS

    N. D. Socci;J. N. Onuchic;P. G. Wolynes

  • Pathway analysis of protein electron-transfer reactions.

    José Nelson Onuchic;David N. Beratan;Jay R. Winkler;Harry B. Gray

  • Electron tunneling through covalent and noncovalent pathways in proteins

    David N. Beratan;José Nelson Onuchic;J. J. Hopfield

  • Folding a protein in a computer: an atomic description of the folding/unfolding of protein A.

    Angel E. García;José N. Onuchic

  • Protein folding funnels: the nature of the transition state ensemble.

    José Nelson Onuchic;Nicholas D. Socci;Zaida Luthey-Schulten;Peter G. Wolynes

  • An all‐atom structure‐based potential for proteins: Bridging minimal models with all‐atom empirical forcefields

    Paul C. Whitford;Jeffrey K. Noel;Shachi Gosavi;Alexander Schug

  • Folding funnels and frustration in off-lattice minimalist protein landscapes

    Hugh Nymeyer;Angel E. García;José Nelson Onuchic

Frequent Co-Authors

Herbert Levine
Herbert Levine Northeastern University
Peter G. Wolynes
Peter G. Wolynes Rice University
Mohit Kumar Jolly
Mohit Kumar Jolly Indian Institute of Science
David N. Beratan
David N. Beratan Duke University
Ron Mittler
Ron Mittler University of Missouri
Jianpeng Ma
Jianpeng Ma Baylor College of Medicine
Nicholas D. Socci
Nicholas D. Socci Memorial Sloan Kettering Cancer Center
Samir M. Hanash
Samir M. Hanash The University of Texas MD Anderson Cancer Center
Angel E. Garcia
Angel E. Garcia Los Alamos National Laboratory
Terence Hwa
Terence Hwa University of California, San Diego

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