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D-Index & Metrics

Biology and Biochemistry

D-Index
75
Citations
24254
World Ranking
5244
National Ranking
2496

Research.com Recognitions

  • 2020 - Member of the National Academy of Sciences
  • 2015 - Fellow of the American Academy of Microbiology Genetics and Molecular Biology
  • 2008 - Fellow of American Physical Society (APS) Citation For fundamental investigations into the statistical physics underlying molecular biology, especially including transcriptional regulation
  • 1999 - Fellow of John Simon Guggenheim Memorial Foundation
  • 1995 - Fellow of Alfred P. Sloan Foundation

Overview

Terence Hwa is affiliated with the University of California, San Diego in the United States. Their research primarily focuses on the intersections of biochemistry, genetics, and molecular biology, with a strong emphasis on molecular biology and genetics among their subfields of study.

The scientist's work covers several main topics, including:

  • Bacterial Genetics and Biotechnology
  • Microbial Metabolic Engineering and Bioproduction
  • Gene Regulatory Network Analysis
  • Microbial Community Ecology and Physiology
  • RNA and protein synthesis mechanisms
  • Evolution and Genetic Dynamics
  • Protein Structure and Dynamics

Terence Hwa has contributed to various publication venues, with frequent appearances in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Proceedings of the National Academy of Sciences
  • Molecular Systems Biology
  • Nature Communications
  • Nature Microbiology

Selected recent papers exemplify the scope of their research:

  • A universal trade-off between growth and lag in fluctuating environments, 2020, Nature
  • From coarse to fine: the absolute Escherichia coli proteome under diverse growth conditions, 2021, Molecular Systems Biology
  • Principles of gene regulation quantitatively connect DNA to RNA and proteins in bacteria, 2022, Science
  • General quantitative relations linking cell growth and the cell cycle in Escherichia coli, 2020, Nature Microbiology
  • Shaping bacterial gene expression by physiological and proteome allocation constraints, 2022, Nature Reviews Microbiology

Frequent collaborators include:

  • Matteo Mori
  • Hiroyuki Okano
  • Zhongge Zhang
  • Brian Taylor
  • Rohan Balakrishnan

Terence Hwa has received various professional distinctions, such as:

  • Member of the National Academy of Sciences (2020)
  • Fellow of the American Academy of Microbiology (2015) in Genetics and Molecular Biology
  • Fellow of the American Physical Society (2008) for investigations into the statistical physics underlying molecular biology, especially transcriptional regulation
  • Fellow of John Simon Guggenheim Memorial Foundation (1999)
  • Fellow of Alfred P. Sloan Foundation (1995)

The body of work and collaborations demonstrate a consistent research focus on bacterial genetics, microbial physiology, and the quantitative analysis of gene regulation and cell growth, situated within a broader molecular biology framework.

Best Publications

  • Direct-coupling analysis of residue coevolution captures native contacts across many protein families

    Faruck Morcos;Andrea Pagnani;Bryan Lunt;Arianna Bertolino

  • Interdependence of Cell Growth and Gene Expression: Origins and Consequences

    Matthew Scott;Carl W. Gunderson;Eduard M. Mateescu;Zhongge Zhang

  • Identification of direct residue contacts in protein-protein interaction by message passing.

    Martin Weigt;Robert A. White;Hendrik Szurmant;James A. Hoch

  • Transcriptional regulation by the numbers: models.

    Lacramioara Bintu;Nicolas E Buchler;Hernan G Garcia;Ulrich Gerland

  • On schemes of combinatorial transcription logic

    Nicolas E. Buchler;Ulrich Gerland;Terence Hwa

  • Growth Rate-Dependent Global Effects on Gene Expression in Bacteria

    Stefan Klumpp;Zhongge Zhang;Terence Hwa

  • Overflow metabolism in Escherichia coli results from efficient proteome allocation

    Markus Basan;Markus Basan;Sheng Hui;Hiroyuki Okano;Zhongge Zhang

  • Transcriptional regulation by the numbers: applications.

    Lacramioara Bintu;Nicolas E Buchler;Hernan G Garcia;Ulrich Gerland

  • Sequential Establishment of Stripe Patterns in an Expanding Cell Population

    Chenli Liu;Xiongfei Fu;Lizhong Liu;Xiaojing Ren

  • Quantitative characteristics of gene regulation by small RNA.

    Erel Levine;Zhongge Zhang;Thomas Kuhlman;Terence Hwa

  • Coordination of bacterial proteome with metabolism by cyclic AMP signalling

    Conghui You;Hiroyuki Okano;Sheng Hui;Zhongge Zhang

  • Emergence of robust growth laws from optimal regulation of ribosome synthesis

    Matthew Scott;Stefan Klumpp;Eduard M Mateescu;Terence Hwa

  • Dissipative transport in open systems: An investigation of self-organized criticality.

    Terence Hwa;Mehran Kardar

  • Quantitative proteomic analysis reveals a simple strategy of global resource allocation in bacteria

    Sheng Hui;Josh M Silverman;Stephen S Chen;David W Erickson

  • Bacterial growth laws and their applications.

    Matthew Scott;Terence Hwa

  • Physical constraints and functional characteristics of transcription factor-DNA interaction.

    Ulrich Gerland;J. David Moroz;Terence Hwa

  • Combinatorial transcriptional control of the lactose operon of Escherichia coli

    Thomas Kuhlman;Zhongge Zhang;Milton H. Saier;Terence Hwa

  • Molecular crowding limits translation and cell growth

    Stefan Klumpp;Matthew Scott;Steen Pedersen;Terence Hwa

  • Transcriptional Regulation by the Numbers 2: Applications

    Lacramioara Bintu;Nicolas E. Buchler;Hernan G. Garcia;Ulrich Gerland

  • Transcriptional Regulation by the Numbers 1: Models

    Lacramioara Bintu;Nicolas E. Buchler;Hernan G. Garcia;Ulrich Gerland

Frequent Co-Authors

José N. Onuchic
José N. Onuchic Rice University
Martin Weigt
Martin Weigt Sorbonne University
James A. Hoch
James A. Hoch Scripps Research Institute
William F. Loomis
William F. Loomis University of California, San Diego
Herbert Levine
Herbert Levine Northeastern University
Dmitri A. Petrov
Dmitri A. Petrov Stanford University

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