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Biology and Biochemistry
UK
2026

D-Index & Metrics

Chemistry

D-Index
119
Citations
57315
World Ranking
512
National Ranking
21

Biology and Biochemistry

D-Index
125
Citations
64913
World Ranking
505
National Ranking
28

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2025 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2023 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2017 - Member of Academia Europaea

Overview

Michele Vendruscolo is affiliated with the University of Cambridge in the United Kingdom. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with a strong focus on Molecular Biology, Physiology, and Neurology as key subfields. The work also touches Computational Theory and Mathematics as well as Cell Biology.

The main topics in Michele Vendruscolo's research encompass Alzheimer's disease research and treatments, Protein Structure and Dynamics, Parkinson's Disease Mechanisms and Treatments, Computational Drug Discovery Methods, RNA Research and Splicing, Monoclonal and Polyclonal Antibodies Research, and Lipid Membrane Structure and Behavior.

Their research output includes publications in a variety of venues with the highest number of papers appearing in bioRxiv (Cold Spring Harbor Laboratory), followed by the Proceedings of the National Academy of Sciences, Nature Communications, Biophysical Journal, and ACS Chemical Neuroscience.

Significant recent papers include:

  • The Amyloid-β Pathway in Alzheimer's Disease, 2021, Molecular Psychiatry
  • Widespread occurrence of the droplet state of proteins in the human proteome, 2020, Proceedings of the National Academy of Sciences
  • Critical assessment of protein intrinsic disorder prediction, 2021, Nature Methods
  • Dynamics of oligomer populations formed during the aggregation of Alzheimer's Aβ42 peptide, 2020, Nature Chemistry
  • Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation, 2020, Molecular Systems Biology

Michele Vendruscolo has collaborated frequently with several researchers, highlighting close working relationships with:

  • Tuomas P. J. Knowles
  • Christopher M. Dobson
  • Z. Faidon Brotzakis
  • Sean Chia
  • Pietro Sormanni

In recognition of their contributions, Michele Vendruscolo was awarded membership in the Academia Europaea in 2017.

Best Publications

  • The amyloid state and its association with protein misfolding diseases

    Tuomas P. J. Knowles;Michele Vendruscolo;Christopher M. Dobson

  • The Amyloid-β Pathway in Alzheimer's Disease.

    Harald Hampel;John Hardy;Kaj Blennow;Kaj Blennow;Christopher Chen

  • Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism

    Samuel I. A. Cohen;Sara Linse;Leila M. Luheshi;Erik Hellstrand

  • An analytical solution to the kinetics of breakable filament assembly

    Tuomas P. J. Knowles;Christopher A. Waudby;Glyn L. Devlin;Samuel I. A. Cohen

  • Promoting transparency and reproducibility in enhanced molecular simulations

    M. Bonomi;M. Bonomi;B. Giovanni;C. Camilloni;G.A. Tribello

  • Parmbsc1: a refined force field for DNA simulations

    Ivan Ivani;Pablo D Dans;Agnes Noy;Alberto Pérez

  • ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function

    Tetsuro Murakami;Seema Qamar;Julie Qiaojin Lin;Gabriele S Kaminski Schierle

  • FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions

    Seema Qamar;Guo Zhen Wang;Suzanne J. Randle;Francesco Simone Ruggeri

  • Role of intermolecular forces in defining material properties of protein nanofibrils.

    Tuomas P. Knowles;Anthony W. Fitzpatrick;Sarah Meehan;Helen R. Mott

  • Mapping Long-Range Interactions in α-Synuclein using Spin-Label NMR and Ensemble Molecular Dynamics Simulations

    Matthew M. Dedmon;Kresten Lindorff-Larsen;John Christodoulou;Michele Vendruscolo

  • Simultaneous determination of protein structure and dynamics

    Kresten Lindorff-Larsen;Kresten Lindorff-Larsen;Robert B. Best;Robert B. Best;Mark A. DePristo;Mark A. DePristo;Christopher M. Dobson

  • Molecular mechanisms of protein aggregation from global fitting of kinetic models

    Georg Meisl;Julius B Kirkegaard;Paolo Arosio;Thomas C T Michaels

  • Amyloid-like Aggregates Sequester Numerous Metastable Proteins with Essential Cellular Functions

    Heidi Olzscha;Sonya M. Schermann;Andreas C. Woerner;Stefan Pinkert

  • Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation

    Alexander K. Buell;Céline Galvagnion;Ricardo Gaspar;Emma Sparr

  • Prediction of "aggregation-prone" and "aggregation-susceptible" regions in proteins associated with neurodegenerative diseases.

    Amol P. Pawar;Kateri F. DuBay;Jesús Zurdo;Fabrizio Chiti

  • Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

    Céline Galvagnion;Alexander K Buell;Georg Meisl;Thomas C T Michaels

  • Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers

    Giuliana Fusco;Giuliana Fusco;Serene W. Chen;Serene W. Chen;Philip T. F. Williamson;Roberta Cascella

  • Widespread Proteome Remodeling and Aggregation in Aging C. elegans

    Dirk M. Walther;Prasad Kasturi;Min Zheng;Stefan Pinkert

  • Atomic structure and hierarchical assembly of a cross-β amyloid fibril

    Anthony W. P. Fitzpatrick;Galia T. Debelouchina;Marvin J. Bayro;Daniel K. Clare

  • Protein structure determination from NMR chemical shifts.

    Andrea Cavalli;Xavier Salvatella;Christopher M. Dobson;Michele Vendruscolo

  • Erratum: The amyloid state and its association with protein misfolding diseases

    Tuomas P. J. Knowles;Michele Vendruscolo;Christopher M. Dobson

Frequent Co-Authors

Christopher M. Dobson
Christopher M. Dobson University of Cambridge
Tuomas P. J. Knowles
Tuomas P. J. Knowles University of Cambridge
Carlo Camilloni
Carlo Camilloni University of Milan
Gian Gaetano Tartaglia
Gian Gaetano Tartaglia Italian Institute of Technology
Sara Linse
Sara Linse Lund University
Fabrizio Chiti
Fabrizio Chiti University of Florence
Paolo Arosio
Paolo Arosio ETH Zurich
Kresten Lindorff-Larsen
Kresten Lindorff-Larsen University of Copenhagen
Richard I. Morimoto
Richard I. Morimoto Northwestern University
Martin Karplus
Martin Karplus Harvard University

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