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Sara Linse

Sara Linse

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Biology and Biochemistry
Sweden
2023

D-Index & Metrics

Chemistry

D-Index
93
Citations
38299
World Ranking
1757
National Ranking
23

Biology and Biochemistry

D-Index
94
Citations
38439
World Ranking
1978
National Ranking
33

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Sweden Leader Award

Overview

Sara Linse is affiliated with Lund University in Sweden. Their research primarily focuses on the intersection of Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions in subfields such as Molecular Biology, Physiology, Neurology, Biomaterials, and Computational Theory and Mathematics.

The core topics of Sara Linse's work include:

  • Alzheimer's disease research and treatments
  • Protein Structure and Dynamics
  • Parkinson's Disease Mechanisms and Treatments
  • Supramolecular Self-Assembly in Materials
  • Lipid Membrane Structure and Behavior
  • Computational Drug Discovery Methods
  • Prion Diseases and Protein Misfolding

Linse has published frequently in several scientific venues. The most common publication platforms include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Proceedings of the National Academy of Sciences
  • ACS Chemical Neuroscience
  • Chemical Science
  • QRB Discovery

Recent papers authored or co-authored by Linse cover multiple aspects of amyloid and protein aggregation research. Selected works include:

  • "Dynamics of oligomer populations formed during the aggregation of Alzheimer's Aβ42 peptide," 2020, Nature Chemistry
  • "Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies," 2020, Nature Structural & Molecular Biology
  • "Kinetic diversity of amyloid oligomers," 2020, Proceedings of the National Academy of Sciences
  • "Amyloid formation as a protein phase transition," 2023, Nature Reviews Physics
  • "Identification of on- and off-pathway oligomers in amyloid fibril formation," 2020, Chemical Science

Sara Linse collaborates frequently with a group of researchers including Tuomas P. J. Knowles, Georg Meisl, Michele Vendruscolo, Emma Sparr, and Thomas C. T. Michaels.

Best Publications

  • Understanding the nanoparticle-protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles.

    Tommy Cedervall;Iseult Lynch;Stina Lindman;Tord Berggård

  • Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism

    Samuel I. A. Cohen;Sara Linse;Leila M. Luheshi;Erik Hellstrand

  • Nucleation of protein fibrillation by nanoparticles

    Sara Linse;Celia Cabaleiro-Lago;Wei-Feng Xue;Iseult Lynch

  • Detailed identification of plasma proteins adsorbed on copolymer nanoparticles.

    Tommy Cedervall;Iseult Lynch;Martina Foy;Tord Berggård

  • Methods for the detection and analysis of protein-protein interactions

    Tord Berggård;Sara Linse;Peter James

  • The nanoparticle-protein complex as a biological entity; a complex fluids and surface science challenge for the 21st century.

    Iseult Lynch;Tommy Cedervall;Martin Lundqvist;Celia Cabaleiro-Lago

  • Atomic Resolution Structure of Monomorphic Aβ42 Amyloid Fibrils

    Michael T. Colvin;Robert Silvers;Qing Zhe Ni;Thach V. Can

  • On the lag phase in amyloid fibril formation

    Paolo Arosio;Tuomas Pertti Knowles;Sara Linse

  • Brain damage and behavioural disorders in fish induced by plastic nanoparticles delivered through the food chain

    Karin Mattsson;Elyse V. Johnson;Anders Malmendal;Sara Linse

  • Molecular mechanisms of protein aggregation from global fitting of kinetic models

    Georg Meisl;Julius B Kirkegaard;Paolo Arosio;Thomas C T Michaels

  • Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation

    Alexander K. Buell;Céline Galvagnion;Ricardo Gaspar;Emma Sparr

  • Food Chain Transport of Nanoparticles Affects Behaviour and Fat Metabolism in Fish

    Tommy Cedervall;Lars-Anders Hansson;Mercy Lard;Birgitta Frohm

  • Calcium binding to calmodulin and its globular domains

    Sara Linse;Anna Helmersson;Sture Forsen

  • Altered Behavior, Physiology, and Metabolism in Fish Exposed to Polystyrene Nanoparticles

    Karin Mattsson;Mikael T. Ekvall;Lars-Anders Hansson;Sara Linse

  • Inhibition of amyloid beta protein fibrillation by polymeric nanoparticles.

    Celia Cabaleiro-Lago;Fiona Quinlan-Pluck;Iseult Lynch;Stina Lindman

  • Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides

    Georg Meisl;Xiaoting Yang;Erik Hellstrand;Birgitta Frohm

  • Systematic investigation of the thermodynamics of HSA adsorption to N-iso-propylacrylamide/N-tert-butylacrylamide copolymer nanoparticles. Effects of particle size and hydrophobicity

    Stina Lindman;Iseult Lynch;Eva Thulin;Hanna Nilsson

  • Conversion of alpha-lactalbumin to a protein inducing apoptosis.

    Malin Svensson;Anders P Håkansson;A K Mossberg;S Linse

  • A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers

    Samuel I A Cohen;Paolo Arosio;Jenny Presto;Firoz Roshan Kurudenkandy

  • Secondary nucleation in amyloid formation.

    Mattias Törnquist;Thomas C T Michaels;Thomas C T Michaels;Kalyani Sanagavarapu;Xiaoting Yang

  • Amyloid beta-Protein Aggregation Produces Highly Reproducible Kinetic Data and Occurs by a Two-Phase Process

    Erik Hellstrand;Barry Boland;Dominic M. Walsh;Sara Linse

Frequent Co-Authors

Tuomas P. J. Knowles
Tuomas P. J. Knowles University of Cambridge
Christopher M. Dobson
Christopher M. Dobson University of Cambridge
Michele Vendruscolo
Michele Vendruscolo University of Cambridge
Paolo Arosio
Paolo Arosio ETH Zurich
Sture Forsén
Sture Forsén Lund University
Mikael Akke
Mikael Akke Lund University
Iseult Lynch
Iseult Lynch University of Birmingham
Kenneth A. Dawson
Kenneth A. Dawson University College Dublin
Torbjörn Drakenberg
Torbjörn Drakenberg Lund University
Jan Johansson
Jan Johansson Karolinska Institute

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