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Mikael Akke

Mikael Akke

D-Index & Metrics

Chemistry

D-Index
50
Citations
9998
World Ranking
14301
National Ranking
213

Overview

Mikael Akke is affiliated with Lund University in Sweden and has a research portfolio concentrated in biochemistry, genetics, and molecular biology. Their work predominantly focuses on protein structure and dynamics, enzyme structure and function, as well as galectins and cancer biology. The research emphasizes advanced nuclear magnetic resonance (NMR) spectroscopy techniques and applications related to molecular biology and disease mechanisms.

Their publication record includes papers in well-regarded journals such as Biochemistry, Proceedings of the National Academy of Sciences, JACS Au, The Journal of Physical Chemistry B, and Nature Communications. Notable recent papers include:

  • "Ultrastructural evidence for self-replication of Alzheimer-associated Aβ42 amyloid along the sides of fibrils," 2020, Proceedings of the National Academy of Sciences
  • "Entropy-Entropy Compensation between the Protein, Ligand, and Solvent Degrees of Freedom Fine-Tunes Affinity in Ligand Binding to Galectin-3C," 2021, JACS Au
  • "Dynamic allosteric communication pathway directing differential activation of the glucocorticoid receptor," 2020, Science Advances
  • "Structural characterization of the microbial enzyme urocanate reductase mediating imidazole propionate production," 2021, Nature Communications
  • "NMR Studies of Aromatic Ring Flips to Probe Conformational Fluctuations in Proteins," 2023, The Journal of Physical Chemistry B

The scientist collaborates frequently with peers such as Olof Stenström, Ulrich Weininger, Göran Carlström, Sven Wernersson, and Ulf J. Nilsson.

Frequent publication venues for their work include:

  • Biochemistry
  • Proceedings of the National Academy of Sciences
  • JACS Au
  • The Journal of Physical Chemistry B
  • Nature Communications

The main fields of study consist of:

  • Biochemistry, Genetics and Molecular Biology

Subfields of their research include:

  • Molecular Biology
  • Immunology
  • Materials Chemistry
  • Spectroscopy
  • Nuclear and High Energy Physics

Key research topics covered by Mikael Akke's work are:

  • Protein Structure and Dynamics
  • Enzyme Structure and Function
  • Galectins and Cancer Biology
  • NMR Spectroscopy and Applications
  • Alzheimer's Disease Research and Treatments
  • Glycosylation and Glycoproteins Research
  • Advanced NMR Techniques and Applications

Best Publications

  • Backbone dynamics of Escherichia coli ribonuclease HI: correlations with structure and function in an active enzyme.

    Arthur M. Mandel;Mikael Akke;Arthur G. Palmer

  • Enzyme dynamics during catalysis.

    Elan Zohar Eisenmesser;Daryl A. Bosco;Mikael Akke;Dorothee Kern

  • NMR order parameters and free energy: an analytical approach and its application to cooperative calcium(2+) binding by calbindin D9k

    Mikael Akke;Rafael Brueschweiler;Arthur G. Palmer

  • Monitoring Macromolecular Motions on Microsecond to Millisecond Time Scales by R1ρ−R1 Constant Relaxation Time NMR Spectroscopy

    Mikael Akke;Arthur G. Palmer

  • Protein Flexibility and Conformational Entropy in Ligand Design Targeting the Carbohydrate Recognition Domain of Galectin-3

    Carl Diehl;Olof Engström;Tamara Delaine;Maria Håkansson

  • Backbone dynamics of calcium-loaded calbindin D9k studied by two-dimensional proton-detected 15N NMR spectroscopy.

    J Kördel;N J Skelton;M Akke;A G Palmer rd

  • Dynamics of ribonuclease H: temperature dependence of motions on multiple time scales.

    A M Mandel;M Akke;A G Palmer rd

  • Fractional 13C enrichment of isolated carbons using [1-13C]- or [2-13C]-glucose facilitates the accurate measurement of dynamics at backbone Ca and side-chain methyl positions in protein

    Patrik Lundström;Kaare Teilum;Tommy Carstensen;Irina Bezsonova;Irina Bezsonova

  • The structure of calcyclin reveals a novel homodimeric fold for S100 Ca(2+)-binding proteins.

    Barbara C. M. Potts;Jarrod Smith;Mikael Akke;Mikael Akke;Thomas J. Macke

  • Effects of ion binding on the backbone dynamics of calbindin D9k determined by 15N NMR relaxation

    Mikael Akke;Nicholas J. Skelton;Johan Kordel;Arthur G. Palmer

  • Practical Aspects of Two-Dimensional Proton-Detected 15N Spin Relaxation Measurements

    N.J. Skelton;A.G. Palmer;M. Akke;J. Kordel

  • Signal transduction versus buffering activity in Ca(2+)-binding proteins.

    Nicholas J. Skelton;Johan Kördel;Mikael Akke;Sture Forsén

  • Structural dynamics in the C-terminal domain of calmodulin at low calcium levels.

    Anders Malmendal;Johan Evenäs;Sture Forsén;Mikael Akke

  • The Carbohydrate-Binding Site in Galectin-3 Is Preorganized To Recognize a Sugarlike Framework of Oxygens: Ultra-High-Resolution Structures and Water Dynamics

    Kadhirvel Saraboji;Maria Håkansson;Samuel Genheden;Carl Diehl

  • NMR methods for characterizing microsecond to millisecond dynamics in recognition and catalysis.

    Mikael Akke

  • From snapshot to movie: φ analysis of protein folding transition states taken one step further

    Tomas Ternström;Ugo Mayor;Mikael Akke;Mikael Oliveberg

  • Backbone dynamics and energetics of a calmodulin domain mutant exchanging between closed and open conformations.

    Johan Evenäs;Sture Forsén;Anders Malmendal;Mikael Akke

  • The ribosomal stalk binds to translation factors IF2, EF-Tu, EF-G and RF3 via a conserved region of the L12 C-terminal domain.

    Magnus Helgstrand;Chandra S. Mandava;Frans A.A. Mulder;Anders Liljas

  • Calbindin D28k Exhibits Properties Characteristic of a Ca2+ Sensor

    Tord Berggård;Simona Miron;Patrik Önnerfjord;Eva Thulin

  • Protein stability and electrostatic interactions between solvent exposed charged side chains

    Mikael Akke;Sture Forsén

Frequent Co-Authors

Walter J. Chazin
Walter J. Chazin Vanderbilt University
Sara Linse
Sara Linse Lund University
Sture Forsén
Sture Forsén Lund University
Ulf Ryde
Ulf Ryde Lund University
Ulf J. Nilsson
Ulf J. Nilsson Lund University
Arthur G. Palmer
Arthur G. Palmer Columbia University
Frans A. A. Mulder
Frans A. A. Mulder Aarhus University
Hakon Leffler
Hakon Leffler Lund University
Pau Bernadó
Pau Bernadó University of Montpellier

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