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Ulf J. Nilsson

Ulf J. Nilsson

D-Index & Metrics

Chemistry

D-Index
64
Citations
11009
World Ranking
8237
National Ranking
109

Overview

Ulf J. Nilsson is affiliated with Lund University in Sweden and conducts research primarily in the fields of Immunology and Microbiology as well as Biochemistry, Genetics, and Molecular Biology. Their work focuses on subfields including Immunology, Molecular Biology, Oncology, Infectious Diseases, and Pharmacology.

The main topics addressed in their research include Galectins and Cancer Biology, Glycosylation and Glycoproteins Research, Toxin Mechanisms and Immunotoxins, Signaling Pathways in Disease, Peptidase Inhibition and Analysis, Macrophage Migration Inhibitory Factor, and Protein Tyrosine Phosphatases.

Ulf J. Nilsson has contributed to several recent papers such as:

  • Target inhibition of galectin-3 by inhaled TD139 in patients with idiopathic pulmonary fibrosis, 2020, European Respiratory Journal
  • Discovery and Optimization of the First Highly Effective and Orally Available Galectin-3 Inhibitors for Treatment of Fibrotic Disease, 2022, Journal of Medicinal Chemistry
  • Entropy-Entropy Compensation between the Protein, Ligand, and Solvent Degrees of Freedom Fine-Tunes Affinity in Ligand Binding to Galectin-3C, 2021, JACS Au
  • Crosstalk between WNT and STAT3 is mediated by galectin-3 in tumor progression, 2021, Gastric Cancer
  • Safety and pharmacokinetics of GB1211, an oral galectin-3 inhibitor: a single- and multiple-dose first-in-human study in healthy participants, 2023, Cancer Chemotherapy and Pharmacology

Frequent co-authors collaborating with Ulf J. Nilsson include:

  • Hakon Leffler
  • Fredrik R. Zetterberg
  • Robert J. Slack
  • Marko Anderluh
  • Anders N. Pedersen

Their research has been published most often in the following venues:

  • Journal of Medicinal Chemistry
  • ChemMedChem
  • RSC Advances
  • bioRxiv (Cold Spring Harbor Laboratory)
  • ACS Chemical Biology

Best Publications

  • Functional adaptation of BabA the H. pylori ABO blood group antigen binding adhesin

    Marina Aspholm-Hurtig;Giedrius Dailide;Martina Lahmann;Awdhesh Kalia

  • Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer’s disease

    Antonio Boza-Serrano;Rocío Ruiz;Raquel Sánchez-Varo;Juan García-Revilla

  • Protein Flexibility and Conformational Entropy in Ligand Design Targeting the Carbohydrate Recognition Domain of Galectin-3

    Carl Diehl;Olof Engström;Tamara Delaine;Maria Håkansson

  • Structural and thermodynamic studies on cation-Pi interactions in lectin-ligand complexes: high-affinity galectin-3 inhibitors through fine-tuning of an arginine-arene interaction.

    Pernilla Sörme;Pascal Arnoux;Barbro Kahl-Knutsson;Hakon Leffler

  • Fluorescence polarization as an analytical tool to evaluate galectin–ligand interactions

    Pernilla Sörme;Barbro Kahl-Knutsson;Margaret Huflejt;Ulf J. Nilsson

  • Experimentally determined swelling pressures and geochemical interactions of compacted Wyoming bentonite with highly alkaline solutions

    Ola Karnland;Siv Olsson;Ulf Nilsson;Patrik Sellin

  • Affinity of galectin-8 and its carbohydrate recognition domains for ligands in solution and at the cell surface

    Susanne Carlsson;Christopher T Öberg;Michael C Carlsson;Anders Sundin

  • Determination of the Degree of Branching in Normal and Amylopectin Type Potato Starch with 1H‐NMR Spectroscopy Improved resolution and two‐dimensional spectroscopy

    Gunilla S. Nilsson;Lo Gorton;Karl-Erik Bergquist;Ulf Nilsson

  • C2-symmetrical thiodigalactoside bis-benzamido derivatives as high-affinity inhibitors of galectin-3: efficient lectin inhibition through double arginine-arene interactions.

    Ian Cumpstey;Anders Sundin;Hakon Leffler;Ulf J. Nilsson

  • Galectin‐3‐Binding Glycomimetics that Strongly Reduce Bleomycin‐Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition

    Tamara Delaine;Patrick Collins;Alison MacKinnon;G. Sharma

  • Kinetics of lead in bone and blood after end of occupational exposure.

    U. Nilsson;R. Attewell;J.-O. Christoffersson;A. Schütz

  • Ligand induced galectin-3 protein self-association.

    Adriana Lepur;Emma Salomonsson;Ulf J. Nilsson;Hakon Leffler

  • The Carbohydrate-Binding Site in Galectin-3 Is Preorganized To Recognize a Sugarlike Framework of Oxygens: Ultra-High-Resolution Structures and Water Dynamics

    Kadhirvel Saraboji;Maria Håkansson;Samuel Genheden;Carl Diehl

  • Low micromolar inhibitors of galectin-3 based on 3'-derivatization of N-acetyllactosamine.

    Pernilla Sörme;Yuning Qian;Per-Georg Nyholm;Hakon Leffler

  • 1H-1,2,3-Triazol-1-yl thiodigalactoside derivatives as high affinity galectin-3 inhibitors

    Bader A. Salameh;Ian Cumpstey;Anders Sundin;Hakon Leffler

  • Mutational Tuning of Galectin-3 Specificity and Biological Function

    Emma Salomonsson;Michael C. Carlsson;Veronica Osla;Ruth Hendus-Altenburger

  • C2-symmetric macrocyclic carbohydrate/amino acid hybrids through copper(I)-catalyzed formation of 1,2,3-triazoles.

    Johan F. Billing;Ulf J. Nilsson

  • 3-(1,2,3-Triazol-1-yl)-1-thio-galactosides as small, efficient, and hydrolytically stable inhibitors of galectin-3

    Bader A. Salameh;Hakon Leffler;Ulf J. Nilsson

  • Double Affinity Amplification of Galectin-Ligand Interactions through Arginine-Arene Interactions: Synthetic, Thermodynamic, and Computational Studies with Aromatic Diamido-Thiodigalactosides.

    Ian Cumpstey;Emma Salomonsson;Anders Sundin;Hakon Leffler

  • Physical Properties of Escherichia coli P Pili Measured by Optical Tweezers

    Jana Jass;Staffan Schedin;Erik Fällman;Jörgen Ohlsson

  • Short-chain fatty acid formation in the hindgut of rats fed oligosaccharides varying in monomeric composition, degree of polymerisation and solubility

    Ulf Nilsson;Margareta Nyman

  • Interplay between Conformational Entropy and Solvation Entropy in Protein-Ligand Binding.

    Maria Luisa Verteramo;Olof Stenström;Majda Misini Ignjatović;Octav Caldararu

  • Galectin-3 Targeted Therapy with a Small Molecule Inhibitor Activates Apoptosis and Enhances Both Chemosensitivity and Radiosensitivity in Papillary Thyroid Cancer

    Chi-Iou Lin;Edward E. Whang;David B. Donner;Xiaofeng Jiang

Frequent Co-Authors

Hakon Leffler
Hakon Leffler Lund University
Margareta Nyman
Margareta Nyman Lund University
Ole Hindsgaul
Ole Hindsgaul University of Alberta
Mikael Akke
Mikael Akke Lund University
Ulf Ryde
Ulf Ryde Lund University
Jukka Finne
Jukka Finne University of Helsinki
Jan Kihlberg
Jan Kihlberg Uppsala University
Staffan Skerfving
Staffan Skerfving Lund University
Toby M. Maher
Toby M. Maher University of Southern California
Roland J. Pieters
Roland J. Pieters Utrecht University

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