World's Best Scientists 2026 revealed!
Hakon Leffler

Hakon Leffler

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Biology and Biochemistry
Sweden
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
99
Citations
32069
World Ranking
1605
National Ranking
27

Hakon Leffler publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Hakon Leffler sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 330 publications — 83rd percentile

83% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Hakon Leffler D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Hakon Leffler sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 99 D-Index — 92nd percentile

92% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Sweden Leader Award

Overview

Hakon Leffler is affiliated with Lund University in Sweden, specializing in research primarily within immunology and microbiology as well as biochemistry, genetics, and molecular biology. Their work extensively covers molecular mechanisms related to galectins, glycosylation, and signaling pathways in disease, with a focus on the biological and pathological roles of galectin-3.

Leffler's recent research publications include the following:

  • Target inhibition of galectin-3 by inhaled TD139 in patients with idiopathic pulmonary fibrosis, 2020, European Respiratory Journal
  • Discovery and Optimization of the First Highly Effective and Orally Available Galectin-3 Inhibitors for Treatment of Fibrotic Disease, 2022, Journal of Medicinal Chemistry
  • Entropy-Entropy Compensation between the Protein, Ligand, and Solvent Degrees of Freedom Fine-Tunes Affinity in Ligand Binding to Galectin-3C, 2021, JACS Au
  • Crosstalk between WNT and STAT3 is mediated by galectin-3 in tumor progression, 2021, Gastric Cancer
  • Safety and pharmacokinetics of GB1211, an oral galectin-3 inhibitor: a single- and multiple-dose first-in-human study in healthy participants, 2023, Cancer Chemotherapy and Pharmacology

Their frequent co-authors include:

  • Ulf J. Nilsson
  • Fredrik R. Zetterberg
  • Robert J. Slack
  • Barbro Kahl-Knutson
  • Kristoffer Peterson

Common publication venues for this scientist comprise:

  • Journal of Medicinal Chemistry
  • ChemMedChem
  • bioRxiv (Cold Spring Harbor Laboratory)
  • iScience
  • Frontiers in Pharmacology

The primary fields of study are:

  • Immunology and Microbiology
  • Biochemistry, Genetics and Molecular Biology

Within these fields, the notable subfields of study include:

  • Immunology
  • Molecular Biology
  • Oncology
  • Cell Biology
  • Pulmonary and Respiratory Medicine

The main research topics addressed by Leffler involve:

  • Galectins and Cancer Biology
  • Glycosylation and Glycoproteins Research
  • Signaling Pathways in Disease
  • Toxin Mechanisms and Immunotoxins
  • Peptidase Inhibition and Analysis
  • Macrophage Migration Inhibitory Factor
  • Protein Tyrosine Phosphatases

Best Publications

  • Galectins. Structure and function of a large family of animal lectins.

    S. H Barondes;D. N. W Cooper;M. A Gitt;H Leffler

  • Galectins: a family of animal beta-galactoside-binding lectins.

    Samuel H. Barondes;Vincent Castronovo;Douglas N W Cooper;Richard D. Cummings

  • Introduction to galectins

    Hakon Leffler;Susanne Carlsson;Maria Hedlund;Yuning Qian

  • Chemical identification of a glycosphingolipid receptor for Escherichia coli attaching to human urinary tract epithelial cells and agglutinating human erythrocytes

    H. Leffler;Catharina Svanborg Edén

  • Regulation of Alternative Macrophage Activation by Galectin-3

    Alison C. MacKinnon;Sarah L. Farnworth;Philip S. Hodkinson;Neil C. Henderson

  • Regulation of Transforming Growth Factor-beta 1-driven Lung Fibrosis by Galectin-3

    Alison C. Mackinnon;Michael A. Gibbons;Sarah L. Farnworth;Hakon Leffler

  • Galectins at a glance.

    Ludger Johannes;Ralf Jacob;Hakon Leffler

  • Galectin-1, -2, and -3 Exhibit Differential Recognition of Sialylated Glycans and Blood Group Antigens

    Sean R. Stowell;Connie M. Arthur;Padmaja Mehta;Kristen A. Slanina

  • X-ray crystal structure of the human galectin-3 carbohydrate recognition domain at 2.1-A resolution.

    J. Seetharaman;Amit Kanigsberg;Rita Slaaby;Hakon Leffler

  • Galectin-3, a marker for vacuole lysis by invasive pathogens.

    Irit Paz;Martin Sachse;Nicolas Dupont;Joelle Mounier

  • Structure of the O-Glycans in GlyCAM-1, an Endothelial-derived Ligand for L-selectin

    Stefan Hemmerich;Hakon Leffler;Steven D. Rosen

  • Specificity of binding of three soluble rat lung lectins to substituted and unsubstituted mammalian beta-galactosides.

    Hakon Leffler;Samuel H. Barondes

  • Multiple soluble beta-galactoside-binding lectins from human lung.

    C P Sparrow;H Leffler;S H Barondes

  • X-ray crystal structure of the human dimeric S-Lac lectin, L-14-II, in complex with lactose at 2.9-A resolution.

    Y D Lobsanov;M A Gitt;H Leffler;S H Barondes

  • Specificity of binding of a strain of uropathogenic Escherichia coli to Gal alpha 1----4Gal-containing glycosphingolipids.

    K Bock;M E Breimer;A Brignole;G C Hansson

  • Identification of an active disaccharide unit of a glycoconjugate receptor for pneumococci attaching to human pharyngeal epithelial cells

    B Andersson;J Dahmén;T Frejd;H Leffler

  • Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation

    Miguel Angel Burguillos;Miguel Angel Burguillos;Martina Svensson;Tim Schulte;Antonio Boza-Serrano

  • Phylogenetic Analysis of the Vertebrate Galectin Family

    Denis Houzelstein;Isabelle R. Gonçalves;Andrew J. Fadden;Sukhvinder S. Sidhu

  • L-29, an endogenous lectin, binds to glycoconjugate ligands with positive cooperativity

    Stephen M. Massa;Douglas N. W. Cooper;Hakon Leffler;Samuel H. Barondes

  • Galectin-3 activates the NADPH-oxidase in exudated but not peripheral blood neutrophils.

    Anna Karlsson;Per Follin;Hakon Leffler;Claes Dahlgren

Frequent Co-Authors

Ulf J. Nilsson
Ulf J. Nilsson Lund University
Gunnar C. Hansson
Gunnar C. Hansson University of Gothenburg
Karl-Anders Karlsson
Karl-Anders Karlsson University of Gothenburg
Samuel H. Barondes
Samuel H. Barondes University of California, San Francisco
Anna Karlsson
Anna Karlsson Skåne University Hospital
Susan J. Fisher
Susan J. Fisher University of California, San Francisco
Ulf Ryde
Ulf Ryde Lund University
Mikael Akke
Mikael Akke Lund University
Göran Larson
Göran Larson University of Gothenburg
Ulf Jodal
Ulf Jodal University of Gothenburg

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