2026 Hakon Leffler: Biology and Biochemistry Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Biology and Biochemistry	99	1605	1449	27	23	330	32069

Research.com Recognitions

2023 - Research.com Biology and Biochemistry in Sweden Leader Award

Overview

Hakon Leffler is affiliated with Lund University in Sweden, specializing in research primarily within immunology and microbiology as well as biochemistry, genetics, and molecular biology. Their work extensively covers molecular mechanisms related to galectins, glycosylation, and signaling pathways in disease, with a focus on the biological and pathological roles of galectin-3.

Leffler's recent research publications include the following:

Target inhibition of galectin-3 by inhaled TD139 in patients with idiopathic pulmonary fibrosis, 2020, European Respiratory Journal
Discovery and Optimization of the First Highly Effective and Orally Available Galectin-3 Inhibitors for Treatment of Fibrotic Disease, 2022, Journal of Medicinal Chemistry
Entropy-Entropy Compensation between the Protein, Ligand, and Solvent Degrees of Freedom Fine-Tunes Affinity in Ligand Binding to Galectin-3C, 2021, JACS Au
Crosstalk between WNT and STAT3 is mediated by galectin-3 in tumor progression, 2021, Gastric Cancer
Safety and pharmacokinetics of GB1211, an oral galectin-3 inhibitor: a single- and multiple-dose first-in-human study in healthy participants, 2023, Cancer Chemotherapy and Pharmacology

Their frequent co-authors include:

Ulf J. Nilsson
Fredrik R. Zetterberg
Robert J. Slack
Barbro Kahl-Knutson
Kristoffer Peterson

Common publication venues for this scientist comprise:

Journal of Medicinal Chemistry
ChemMedChem
bioRxiv (Cold Spring Harbor Laboratory)
iScience
Frontiers in Pharmacology

The primary fields of study are:

Immunology and Microbiology
Biochemistry, Genetics and Molecular Biology

Within these fields, the notable subfields of study include:

Immunology
Molecular Biology
Oncology
Cell Biology
Pulmonary and Respiratory Medicine

The main research topics addressed by Leffler involve:

Galectins and Cancer Biology
Glycosylation and Glycoproteins Research
Signaling Pathways in Disease
Toxin Mechanisms and Immunotoxins
Peptidase Inhibition and Analysis
Macrophage Migration Inhibitory Factor
Protein Tyrosine Phosphatases

Best Publications

Galectins. Structure and function of a large family of animal lectins.

S. H Barondes;D. N. W Cooper;M. A Gitt;H Leffler

2200
Citations
Galectins: a family of animal beta-galactoside-binding lectins.

Samuel H. Barondes;Vincent Castronovo;Douglas N W Cooper;Richard D. Cummings

1642
Citations
Introduction to galectins

Hakon Leffler;Susanne Carlsson;Maria Hedlund;Yuning Qian

835
Citations
Chemical identification of a glycosphingolipid receptor for Escherichia coli attaching to human urinary tract epithelial cells and agglutinating human erythrocytes

H. Leffler;Catharina Svanborg Edén

750
Citations
Regulation of Alternative Macrophage Activation by Galectin-3

Alison C. MacKinnon;Sarah L. Farnworth;Philip S. Hodkinson;Neil C. Henderson

636
Citations
Regulation of Transforming Growth Factor-beta 1-driven Lung Fibrosis by Galectin-3

Alison C. Mackinnon;Michael A. Gibbons;Sarah L. Farnworth;Hakon Leffler

592
Citations
Galectins at a glance.

Ludger Johannes;Ralf Jacob;Hakon Leffler

587
Citations
Galectin-1, -2, and -3 Exhibit Differential Recognition of Sialylated Glycans and Blood Group Antigens

Sean R. Stowell;Connie M. Arthur;Padmaja Mehta;Kristen A. Slanina

543
Citations
X-ray crystal structure of the human galectin-3 carbohydrate recognition domain at 2.1-A resolution.

J. Seetharaman;Amit Kanigsberg;Rita Slaaby;Hakon Leffler

516
Citations
Galectin-3, a marker for vacuole lysis by invasive pathogens.

Irit Paz;Martin Sachse;Nicolas Dupont;Joelle Mounier

424
Citations
Structure of the O-Glycans in GlyCAM-1, an Endothelial-derived Ligand for L-selectin

Stefan Hemmerich;Hakon Leffler;Steven D. Rosen

420
Citations
Specificity of binding of three soluble rat lung lectins to substituted and unsubstituted mammalian beta-galactosides.

Hakon Leffler;Samuel H. Barondes

407
Citations
Multiple soluble beta-galactoside-binding lectins from human lung.

C P Sparrow;H Leffler;S H Barondes

379
Citations
X-ray crystal structure of the human dimeric S-Lac lectin, L-14-II, in complex with lactose at 2.9-A resolution.

Y D Lobsanov;M A Gitt;H Leffler;S H Barondes

376
Citations
Specificity of binding of a strain of uropathogenic Escherichia coli to Gal alpha 1----4Gal-containing glycosphingolipids.

K Bock;M E Breimer;A Brignole;G C Hansson

372
Citations
Identification of an active disaccharide unit of a glycoconjugate receptor for pneumococci attaching to human pharyngeal epithelial cells

B Andersson;J Dahmén;T Frejd;H Leffler

364
Citations
Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation

Miguel Angel Burguillos;Miguel Angel Burguillos;Martina Svensson;Tim Schulte;Antonio Boza-Serrano

360
Citations
Phylogenetic Analysis of the Vertebrate Galectin Family

Denis Houzelstein;Isabelle R. Gonçalves;Andrew J. Fadden;Sukhvinder S. Sidhu

358
Citations
L-29, an endogenous lectin, binds to glycoconjugate ligands with positive cooperativity

Stephen M. Massa;Douglas N. W. Cooper;Hakon Leffler;Samuel H. Barondes

356
Citations
Galectin-3 activates the NADPH-oxidase in exudated but not peripheral blood neutrophils.

Anna Karlsson;Per Follin;Hakon Leffler;Claes Dahlgren

292
Citations