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Mitsuomi Hirashima

Mitsuomi Hirashima

D-Index & Metrics

Immunology

D-Index
69
Citations
19068
World Ranking
2495
National Ranking
97

Overview

Mitsuomi Hirashima is affiliated with Kagawa University in Japan and specializes in research that spans immunology, microbiology, biochemistry, genetics, and molecular biology. Their work primarily addresses molecular mechanisms involved in cancer biology and immune system function, with a particular focus on the roles of galectins and signaling pathways in disease.

Their main research topics include:

  • Galectins and Cancer Biology
  • Signaling Pathways in Disease
  • Peptidase Inhibition and Analysis
  • Circular RNAs in diseases
  • Glycosylation and Glycoproteins Research
  • Protein Tyrosine Phosphatases
  • T-cell and Retrovirus Studies

The scientist has contributed to multiple publications examining the biological functions of galectin-9 and its effects on tumor growth and immune cell behavior. Recent papers authored or co-authored by Hirashima include:

  • "Galectin-9 mediates neutrophil capture and adhesion in a CD44 and β2 integrin-dependent manner," 2021, The FASEB Journal
  • "Galectin-9 suppresses the tumor growth of colon cancer in vitro and in vivo," 2021, Oncology Reports
  • "Antitumor Effect of Galectin-9 on Cell Proliferation and Tumor Growth of Human Duodenal Adenocarcinoma Cells," 2023, Anticancer Research
  • "Editor's Note: Targeting Activating Transcription Factor 3 by Galectin-9 Induces Apoptosis and Overcomes Various Types of Treatment Resistance in Chronic Myelogenous Leukemia," 2024, Molecular Cancer Research

The venues where Hirashima frequently publishes include The FASEB Journal, Oncology Reports, Anticancer Research, and Molecular Cancer Research. Their collaborative work involves several frequent co-authors, such as Toshiro Niki, Kei Takuma, Kyoko Oura, Taiga Chiyo, and Asif Iqbal.

The research contributions of Mitsuomi Hirashima reflect an interdisciplinary approach combining immunology and molecular biology to study cancer progression and immune modulation. Their focus on galectin proteins ties into broader investigations of signaling pathways and cellular interactions in disease contexts.

Best Publications

  • Tumor-infiltrating DCs suppress nucleic acid–mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1

    Shigeki Chiba;Muhammad Baghdadi;Hisaya Akiba;Hironori Yoshiyama

  • Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells.

    Ana C. Anderson;David E. Anderson;Lisa Bregoli;William D. Hastings

  • Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia

    Qing Zhou;Meghan E. Munger;Rachelle G. Veenstra;Brenda J. Weigel

  • Human Galectin-3 Is a Novel Chemoattractant for Monocytes and Macrophages

    Hideki Sano;Daniel K. Hsu;Lan Yu;John R. Apgar

  • Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis

    Masako Seki;Souichi Oomizu;Ken mei Sakata;Atsuko Sakata

  • Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells.

    Jihène Klibi;Toshiro Niki;Alexander Riedel;Catherine Pioche-Durieu

  • Galectin-9 Induces Apoptosis Through the Calcium-Calpain-Caspase-1 Pathway

    Yumiko Kashio;Kazuhiro Nakamura;Mohammad J. Abedin;Masako Seki

  • Tim-3 is an inducible human natural killer cell receptor that enhances interferon gamma production in response to galectin-9

    Michelle K. Gleason;Todd R. Lenvik;Valarie McCullar;Martin Felices

  • IL-12 upregulates TIM-3 expression and induces T cell exhaustion in patients with follicular B cell non-Hodgkin lymphoma

    Zhi Zhang Yang;Deanna M. Grote;Steven C. Ziesmer;Toshiro Niki

  • Human ecalectin, a variant of human galectin-9, is a novel eosinophil chemoattractant produced by T lymphocytes

    Ryoji Matsumoto;Hiroyuki Matsumoto;Masako Seki;Mitsumi Hata

  • Galectin-9-CD44 Interaction Enhances Stability and Function of Adaptive Regulatory T Cells

    Chuan Wu;Theresa Thalhamer;Rafael F. Franca;Sheng Xiao

  • Tim-3/Galectin-9 Pathway: Regulation of Th1 Immunity through Promotion of CD11b+Ly-6G+ Myeloid Cells

    Valerie Dardalhon;Ana C. Anderson;Jozsef Karman;Lionel Apetoh

  • An Emerging Role for Galectins in Tuning the Immune Response: Lessons from Experimental Models of Inflammatory Disease, Autoimmunity and Cancer

    Gabriel Adrián Rabinovich;F. T. Liu;M. Hirashima;A. Anderson

  • Exosomes released by EBV-infected nasopharyngeal carcinoma cells convey the viral Latent Membrane Protein 1 and the immunomodulatory protein galectin 9

    Cécile Keryer-Bibens;Catherine Pioche-Durieu;Cécile Villemant;Sylvie Souquère

  • Galectin-9 Increases Tim-3+ Dendritic Cells and CD8+ T Cells and Enhances Antitumor Immunity via Galectin-9-Tim-3 Interactions

    Keiko Nagahara;Tomohiro Arikawa;Souichi Oomizu;Keiichi Kontani

  • Galectin-9 induces maturation of human monocyte-derived dendritic cells.

    Shu-Yan Dai;Ryusuke Nakagawa;Aiko Itoh;Hiromoto Murakami

  • Galectin-9 as a prognostic factor with antimetastatic potential in breast cancer.

    Akemi Irie;Akira Yamauchi;Keiichi Kontani;Minoru Kihara

  • Interferon-γ stimulates the expression of galectin-9 in cultured human endothelial cells

    Tadaatsu Imaizumi;Mika Kumagai;Naoko Sasaki;Hidekachi Kurotaki

  • A Crucial Role for Kupffer Cell-Derived Galectin-9 in Regulation of T Cell Immunity in Hepatitis C Infection

    John A. Mengshol;Lucy Golden-Mason;Tomohiro Arikawa;Maxwell Smith

  • Galectin-9 is a high affinity IgE-binding lectin with anti-allergic effect by blocking IgE-antigen complex formation

    Toshiro Niki;Shoko Tsutsui;Shigeru Hirose;Sachiko Aradono

  • Possible role of galectin-9 in cell aggregation and apoptosis of human melanoma cell lines and its clinical significance.

    Toshiro Kageshita;Yumiko Kashio;Akira Yamauchi;Masako Seki

Frequent Co-Authors

Akira Yamauchi
Akira Yamauchi Kawasaki Medical School
Akira Yamauchi
Akira Yamauchi Nagoya University
Masayuki Ando
Masayuki Ando Kumamoto University
Vijay K. Kuchroo
Vijay K. Kuchroo Harvard University
Tadaatsu Imaizumi
Tadaatsu Imaizumi Hirosaki University
Hugo R. Rosen
Hugo R. Rosen University of Southern California
Kei Satoh
Kei Satoh Hirosaki University
Ana C. Anderson
Ana C. Anderson Brigham and Women's Hospital
Barry T. Rouse
Barry T. Rouse University of Tennessee at Knoxville
Michael Croft
Michael Croft La Jolla Institute For Allergy & Immunology

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