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Biology and Biochemistry
Canada
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
86
Citations
26697
World Ranking
2963
National Ranking
92

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Canada Leader Award
  • 2012 - Fellow of the Royal Society of Canada Academy of Science

Overview

James W. Dennis is affiliated with the Lunenfeld-Tanenbaum Research Institute in Canada. Their research spans several interconnected areas within biochemistry, genetics, and molecular biology, focusing on detailed cellular and molecular processes.

Their recent publications include the following notable papers:

  • A Genetic Map of the Response to DNA Damage in Human Cells, 2020, Cell
  • Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism, 2020, Nature Metabolism
  • The GATOR-Rag GTPase pathway inhibits mTORC1 activation by lysosome-derived amino acids, 2020, Science
  • A noncoding single-nucleotide polymorphism at 8q24 drives IDH1-mutant glioma formation, 2022, Science
  • Glioma stem cells invasive phenotype at optimal stiffness is driven by MGAT5 dependent mechanosensing, 2021, Journal of Experimental & Clinical Cancer Research

The scientist collaborates regularly with a group of coauthors, including:

  • Judy Pawling (16 joint publications)
  • Anne-Claude Gingras (6 joint publications)
  • Geoffrey G. Hesketh (4 joint publications)
  • Daniel Schramek (4 joint publications)
  • Cunjie Zhang (4 joint publications)

James W. Dennis publishes frequently in the following venues:

  • Journal of Biological Chemistry (4 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (3 publications)
  • Science (2 publications)
  • The FASEB Journal (2 publications)
  • Cell (1 publication)

The principal fields of study for this scientist are biochemistry, genetics, and molecular biology, with 36 documented publications, and medicine, with 16 publications. Their subfields include molecular biology, cell biology, immunology, cancer research, and biochemistry.

The main topics explored in their work encompass:

  • Glycosylation and Glycoproteins Research
  • Cellular transport and secretion
  • CRISPR and Genetic Engineering
  • Galectins and Cancer Biology
  • Glioma Diagnosis and Treatment
  • Genomics and Chromatin Dynamics
  • Amino Acid Enzymes and Metabolism

James W. Dennis received the award of Fellow of the Royal Society of Canada in 2012, recognized by the Academy of Science.

Best Publications

  • Beta 1-6 branching of Asn-linked oligosaccharides is directly associated with metastasis

    James W. Dennis;Suzanne Laferté;Carol Waghorne;Martin L. Breitman

  • Negative regulation of T-cell activation and autoimmunity by Mgat5 N -glycosylation

    Michael Demetriou;Maria Granovsky;Sue Quaggin;James W. Dennis;James W. Dennis

  • Complex N-Glycan Number and Degree of Branching Cooperate to Regulate Cell Proliferation and Differentiation

    Ken S. Lau;Ken S. Lau;Emily A. Partridge;Emily A. Partridge;Ani Grigorian;Cristina I. Silvescu

  • Glycoprotein glycosylation and cancer progression

    James W. Dennis;Maria Granovsky;Maria Granovsky;Charles E. Warren

  • Regulation of cytokine receptors by Golgi N-glycan processing and endocytosis.

    Emily A. Partridge;Christine Le Roy;Gianni M. Di Guglielmo;Judy Pawling

  • Suppression of tumor growth and metastasis in Mgat5-deficient mice.

    Maria Granovsky;Maria Granovsky;Jimmie Fata;Judy Pawling;William J. Muller

  • Interferon alfacon-1 plus corticosteroids in severe acute respiratory syndrome: a preliminary study.

    Mona R. Loutfy;Lawrence M. Blatt;Katharine A. Siminovitch;Sarah Ward

  • Protein glycosylation in development and disease.

    James W. Dennis;Maria Granovsky;Maria Granovsky;Charles E. Warren

  • Inhibitors of carbohydrate processing: A new class of anticancer agents.

    Paul E Goss;Michael A. Baker;Jeremy P. Carver;James W. Dennis

  • Metabolism, Cell Surface Organization, and Disease

    James W. Dennis;James W. Dennis;Ivan R. Nabi;Michael Demetriou

  • N-Glycans in cancer progression

    Ken S Lau;James W Dennis

  • A Genetic Map of the Response to DNA Damage in Human Cells

    Michele Olivieri;Michele Olivieri;Tiffany Cho;Tiffany Cho;Alejandro Álvarez-Quilón;Kejiao Li

  • Lattices, rafts, and scaffolds: domain regulation of receptor signaling at the plasma membrane

    Patrick Lajoie;Jacky G. Goetz;James W. Dennis;Ivan R. Nabi

  • The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism

    Kathryn E. Wellen;Chao Lu;Anthony Mancuso;Johanna M.S. Lemons

  • Glycosylation, galectins and cellular signaling

    Cecile Boscher;James W Dennis;Ivan R Nabi

  • Fetuin/α2-HS Glycoprotein Is a Transforming Growth Factor-β Type II Receptor Mimic and Cytokine Antagonist

    Michael Demetriou;Christoph Binkert;Balram Sukhu;Howard C. Tenenbaum;Howard C. Tenenbaum

  • The galectin lattice at a glance.

    Ivan R. Nabi;Jay Shankar;James W. Dennis

  • Reduced contact-inhibition and substratum adhesion in epithelial cells expressing GlcNAc-transferase V.

    Michael Demetriou;Ivan R. Nabi;Marc Coppolino;Shoukat Dedhar

  • Phase IB clinical trial of the oligosaccharide processing inhibitor swainsonine in patients with advanced malignancies.

    P E Goss;C L Reid;D Bailey;J W Dennis

  • Interferon Alfacon-1 Plus Corticosteroids in Severe Acute Respiratory Syndrome

    Mona R. Loutfy;Lawrence M. Blatt;Katharine A. Siminovitch;Sarah Ward

Frequent Co-Authors

Michael A. Demetriou
Michael A. Demetriou Worcester Polytechnic Institute
Ivan R. Nabi
Ivan R. Nabi University of British Columbia
Alessandro Datti
Alessandro Datti University of Perugia
Anne-Claude Gingras
Anne-Claude Gingras Lunenfeld-Tanenbaum Research Institute
Tony Pawson
Tony Pawson University of Toronto
Robert S. Kerbel
Robert S. Kerbel University of Toronto
Jeffrey L. Wrana
Jeffrey L. Wrana Lunenfeld-Tanenbaum Research Institute
Katherine A. Siminovitch
Katherine A. Siminovitch Lunenfeld-Tanenbaum Research Institute
John C. Roder
John C. Roder University of Toronto
Paul E. Goss
Paul E. Goss Harvard University

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