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D-Index & Metrics

Genetics

D-Index
92
Citations
30789
World Ranking
1002
National Ranking
29

Medicine

D-Index
98
Citations
35642
World Ranking
8913
National Ranking
350

Research.com Recognitions

  • 2013 - Fellow of the Royal Society of Canada Academy of Science

Overview

Katherine A. Siminovitch is affiliated with the Lunenfeld-Tanenbaum Research Institute in Canada. Their work primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with notable focus on Genetics, Molecular Biology, Cardiology and Cardiovascular Medicine, Pathology and Forensic Medicine, and Rheumatology.

The main research topics covered by their publications include Genetic Associations and Epidemiology, Genomics and Rare Diseases, BRCA gene mutations in cancer, Lymphoma Diagnosis and Treatment, PARP inhibition in cancer therapy, Atrial Fibrillation Management and Outcomes, and Liver Disease Diagnosis and Treatment.

Their recent academic contributions include the following papers:

  • Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis, 2022, Nature Genetics
  • Analysis of rare genetic variation underlying cardiometabolic diseases and traits among 200,000 individuals in the UK Biobank, 2022, Nature Genetics
  • A deep catalogue of protein-coding variation in 983,578 individuals, 2024, Nature
  • Genotyping, sequencing and analysis of 140,000 adults from Mexico City, 2023, Nature
  • High heritability of ascending aortic diameter and trans-ancestry prediction of thoracic aortic disease, 2022, Nature Genetics

A number of frequent co-authors have collaborated with Katherine A. Siminovitch, including:

  • John D. Overton
  • Jeffrey G. Reid
  • Gonçalo R. Abecasis
  • Luca A. Lotta
  • Alan R. Shuldiner

Their research is often published in journals such as:

  • Nature Genetics
  • Nature
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Communications Biology
  • JAMA Cardiology

Katherine A. Siminovitch received the award of Fellow of the Royal Society of Canada in 2013 from the Academy of Science.

Best Publications

  • Genetics of rheumatoid arthritis contributes to biology and drug discovery

    Yukinori Okada;Yukinori Okada;Di Wu;Di Wu;Di Wu;Gosia Trynka;Gosia Trynka;Towfique Raj;Towfique Raj

  • Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

    Eli A Stahl;Soumya Raychaudhuri;Soumya Raychaudhuri;Elaine F Remmers;Gang Xie

  • Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis

    Soumya Raychaudhuri;Cynthia Sandor;Eli A. Stahl;Eli A. Stahl;Jan Freudenberg

  • Functional variants of OCTN cation transporter genes are associated with Crohn disease.

    Vanya D Peltekova;Richard F Wintle;Laurence A Rubin;Laurence A Rubin;Christopher I Amos

  • Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease.

    John D. Rioux;Mark J. Daly;Mark S. Silverberg;Kerstin Lindblad

  • Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants.

    Gideon M. Hirschfield;Xiangdong Liu;Chun Xu;Yue Lu

  • Pervasive sharing of genetic effects in autoimmune disease.

    Chris Cotsapas;Benjamin F. Voight;Benjamin F. Voight;Elizabeth Rossin;Kasper Lage;Kasper Lage;Kasper Lage

  • Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci.

    John D. Rioux;Mark S. Silverberg;Mark J. Daly;A. Hillary Steinhart

  • Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases A Mendelian Randomization Study

    Philip C Haycock;Stephen Burgess;Aayah Nounu

  • The role of viscosupplementation with hylan G-F 20 (Synvisc®) in the treatment of osteoarthritis of the knee: a Canadian multicenter trial comparing hylan G-F 20 alone, hylan G-F 20 with non-steroidal anti-inflammatory drugs (NSAIDs) and NSAIDs alone

    Mark E. Adams;Martin H. Atkinson;André J. Lussier;Jan I. Schulz

  • Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis

    Eli A Stahl;Daniel Wegmann;Gosia Trynka;Javier Gutierrez-Achury

  • Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis

    Xiangdong Liu;Pietro Invernizzi;Yue Lu;Roman Kosoy

  • The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells

    Yiling Lu;Yue Zhen Lin;Ruth LaPushin;Bruce Cuevas

  • Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci

    Alexandra Zhernakova;Alexandra Zhernakova;Alexandra Zhernakova;Eli A. Stahl;Eli A. Stahl;Gosia Trynka;Soumya Raychaudhuri

  • Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein.

    Norzehan Abdul-Manan;Behzad Aghazadeh;Behzad Aghazadeh;Grace A. Liu;Ananya Majumdar

  • Roles of the SHP-1 tyrosine phosphatase in the negative regulation of cell signalling.

    Jinyi Zhang;Ally Khan Somani;Katherine A. Siminovitch

  • Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes.

    Jinyi Zhang;Amro Shehabeldin;Luis A.G. Da Cruz;Jeffrey Butler

  • REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.

    Peter K Gregersen;Chistopher I Amos;Annette T Lee;Yue Lu

  • Analysis of gene expression in a complex differentiation hierarchy by global amplification of cDNA from single cells

    Gerard Brady;Filio Billia;Jennifer Knox;Trang Hoang

  • Pervasive Sharing of Genetic Effects in Autoimmune Disease

    Chris Cotsapas;Benjamin F. Voight;Elizabeth Rossin;Kasper Lage

Frequent Co-Authors

Christopher I. Amos
Christopher I. Amos Baylor College of Medicine
Robert M. Plenge
Robert M. Plenge Bristol Myers Squibb
Soumya Raychaudhuri
Soumya Raychaudhuri Brigham and Women's Hospital
Peter K. Gregersen
Peter K. Gregersen Feinstein Institute for Medical Research
Gideon M. Hirschfield
Gideon M. Hirschfield University Health Network
Eli A. Stahl
Eli A. Stahl Icahn School of Medicine at Mount Sinai
Jane Worthington
Jane Worthington University of Manchester
Gordon B. Mills
Gordon B. Mills Oregon Health & Science University
Thomas J. Hudson
Thomas J. Hudson Ontario Institute for Cancer Research
Mark J. Daly
Mark J. Daly Massachusetts General Hospital

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