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Chemistry
Japan
2026

D-Index & Metrics

Chemistry

D-Index
106
Citations
33810
World Ranking
971
National Ranking
44

Research.com Recognitions

  • 2026 - Research.com Chemistry in Japan Leader Award
  • 2025 - Research.com Chemistry in Japan Leader Award
  • 2022 - Research.com Chemistry in Japan Leader Award

Overview

Hisashi Matsuda is a researcher affiliated with Kyoto Pharmaceutical University in Japan. Their primary field of study is Biochemistry, Genetics and Molecular Biology, with a focus on Molecular Biology and Pharmacology as key subfields. They also have contributions to Plant Science, Electrical and Electronic Engineering, and Complementary and Alternative Medicine.

The scientific work of Matsuda covers a range of topics related to natural products and bioactivities, including research on phytochemical compounds and their biological activities. They have investigated bioactive compounds from plants such as garlic and onion and have explored the mechanisms and applications of these substances. Other research areas include aerosol filtration and electrostatic precipitation, fungal plant pathogen control, and the biological activities of phytochemicals and antioxidants. There is also work centered on berberine and alkaloid compounds.

Matsuda has authored papers in various scientific journals, notably with multiple publications in the Journal of Natural Medicines and contributions to venues such as Organic & Biomolecular Chemistry, The Proceedings of Conference of Hokkaido Branch, Traditional & Kampo Medicine, Chemical and Pharmaceutical Bulletin, and Heterocycles.

Recent papers from Matsuda's research include:

  • A review of antidiabetic active thiosugar sulfoniums, salacinol and neokotalanol, from plants of the genus Salacia (2021, Journal of Natural Medicines)
  • Inhibitory effects of cynaropicrin and related sesquiterpene lactones from leaves of artichoke (Cynara scolymus L.) on induction of iNOS in RAW264.7 cells and its high-affinity proteins (2021, Journal of Natural Medicines)
  • Effects of Sanoshashinto on left ventricular hypertrophy and gut microbiota in spontaneously hypertensive rats (2020, Journal of Natural Medicines)
  • Construction of sulfur-containing compounds with anti-cancer stem cell activity using thioacrolein derived from garlic based on nature-inspired scaffolds (2021, Organic & Biomolecular Chemistry)
  • Antihypertensive constituents in Sanoshashinto (2020, Journal of Natural Medicines)

Matsuda often collaborates with other researchers. Frequent coauthors include Seikou Nakamura, Souichi Nakashima, Nobuyoshi Watanabe, Masayuki Yoshikawa, and Hideaki Sato, reflecting an active participation in collaborative scientific efforts.

Best Publications

  • Adjuvant and haemolytic activities of 47 saponins derived from medicinal and food plants.

    Kenji Oda;Hisashi Matsuda;Toshiyuki Murakami;Shigeji Katayama

  • Salacinol, potent antidiabetic principle with unique thiosugar sulfonium sulfate structure from the ayurvedic traditional medicine Salacia reticulata in Sri Lanka and India

    Masayuki Yoshikawa;Toshiyuki Murakami;Hiromi Shimada;Hisashi Matsuda

  • Kotalanol, a Potent α-Glucosidase Inhibitor with Thiosugar Sulfonium Sulfate Structure, from Antidiabetic Ayurvedic Medicine Salacia reticulata

    Masayuki Yoshikawa;Toshiyuki Murakami;Kenichi Yashiro;Hisashi Matsuda

  • Structural requirements of flavonoids for inhibition of protein glycation and radical scavenging activities.

    Hisashi Matsuda;Tao Wang;Hiromi Managi;Masayuki Yoshikawa

  • Salacia reticulata and Its Polyphenolic Constituents with Lipase Inhibitory and Lipolytic Activities Have Mild Antiobesity Effects in Rats

    Masayuki Yoshikawa;Hiroshi Shimoda;Norihisa Nishida;Miki Takada

  • Carnosic acid, a new class of lipid absorption inhibitor from sage

    Kiyofumi Ninomiya;Hisashi Matsuda;Hiroshi Shimoda;Norihisa Nishida

  • Absolute Stereostructure of Potent α-Glucosidase Inhibitor, Salacinol, with Unique Thiosugar Sulfonium Sulfate Inner Salt Structure from Salacia reticulata

    Masayuki Yoshikawa;Toshio Morikawa;Hisashi Matsuda;Genzoh Tanabe

  • Structural Requirements of Flavonoids and Related Compounds for Aldose Reductase Inhibitory Activity

    Hisashi Matsuda;Toshio Morikawa;Iwao Toguchida;Masayuki Yoshikawa

  • Structural requirements of flavonoids for nitric oxide production inhibitory activity and mechanism of action.

    Hisashi Matsuda;Toshio Morikawa;Shin Ando;Iwao Toguchida

  • Structures of withanosides I, II, III, IV, V, VI, and VII, new withanolide glycosides, from the roots of Indian Withania somnifera DUNAL. and inhibitory activity for tachyphylaxis to clonidine in isolated guinea-pig ileum.

    Hisashi Matsuda;Toshiyuki Murakami;Akinobu Kishi;Masayuki Yoshikawa

  • Microginin, an angiotensin-converting enzyme inhibitor from the blue-green alga Microcystis aeruginosa

    Tatsufumi Okino;Hisashi Matsuda;Masahiro Murakami;Katsumi Yamaguchi

  • Inhibitory effect and action mechanism of sesquiterpenes from Zedoariae Rhizoma on D-galactosamine/lipopolysaccharide-induced liver injury.

    Hisashi Matsuda;Kiyofumi Ninomiya;Toshio Morikawa;Masayuki Yoshikawa

  • Antioxidant constituents from rhubarb: structural requirements of stilbenes for the activity and structures of two new anthraquinone glucosides.

    Hisashi Matsuda;Toshio Morikawa;Iwao Toguchida;Ji-Young Park

  • Structures of new dammarane-type Triterpene Saponins from the flower buds of Panax notoginseng and hepatoprotective effects of principal Ginseng Saponins.

    Masayuki Yoshikawa;Toshio Morikawa;Yousuke Kashima;Kiyofumi Ninomiya

  • Medicinal Foodstuffs. XXI. Structures of New Cucurbitane-Type Triterpene Glycosides, Goyaglycosides-a, -b, -c, -d, -e, -f, -g, and -h, and New Oleanane-Type Triterpene Saponins, Goyasaponins I, II, and III, from the Fresh Fruit of Japanese Momordica charantia L.

    Toshiyuki Murakami;Akihito Emoto;Hisashi Matsuda;Masayuki Yoshikawa

  • New crinine-type alkaloids with inhibitory effect on induction of inducible nitric oxide synthase from Crinum yemense.

    Osama Bashir Abdel-Halim;Toshio Morikawa;Shin Ando;Hisashi Matsuda

  • Phytoestrogens from the roots of Polygonum cuspidatum (polygonaceae): structure-Requirement of hydroxyanthraquinones for estrogenic activity

    Hisashi Matsuda;Hiroshi Shimoda;Toshio Morikawa;Masayuki Yoshikawa

  • Structure-requirements of isocoumarins, phthalides, and stilbenes from Hydrangeae Dulcis Folium for inhibitory activity on histamine release from rat peritoneal mast cells

    Hisashi Matsuda;Hiroshi Shimoda;Masayuki Yoshikawa

  • Medicinal Foodstuffs. IV. Fenugreek Seed. (1) : Structures of Trigoneosides Ia, Ib, IIa, IIb, IIIa, and IIIb, New Furostanol Saponins from the Seeds of Indian Trigonella foenum-graecum L.

    Masayuki Yoshikawa;Toshiyuki Murakami;Hajime Komatsu;Nobutoshi Murakami

  • Effects of stilbene constituents from rhubarb on nitric oxide production in lipopolysaccharide-activated macrophages.

    Hisashi Matsuda;Tadashi Kageura;Toshio Morikawa;Iwao Toguchida

  • Antidiabetic Principles of Natural Medicines. IV. Aldose Reductase and α-Glucosidase Inhibitors from the Roots of Salacia oblonga WALL. (Celastraceae) : Structure of a New Friedelane-Type Triterpene, Kotalagenin 16-Acetate

    Hisashi Matsuda;Toshiyuki Murakami;Kenichi Yashiro;Johji Yamahara

Frequent Co-Authors

Masayuki Yoshikawa
Masayuki Yoshikawa Kyoto Pharmaceutical University
Toshio Morikawa
Toshio Morikawa Kindai University
Seikou Nakamura
Seikou Nakamura Kyoto Pharmaceutical University
Johji Yamahara
Johji Yamahara Kyoto Pharmaceutical University
Toshiyuki Murakami
Toshiyuki Murakami Kyoto Pharmaceutical University
Osamu Muraoka
Osamu Muraoka Kindai University
Paul W. Paré
Paul W. Paré Texas Tech University
Masahiro Murakami
Masahiro Murakami Kyoto University
Isao Kitagawa
Isao Kitagawa Osaka University
Hiroki R. Ueda
Hiroki R. Ueda University of Tokyo

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