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Chemistry

D-Index
58
Citations
9741
World Ranking
10835
National Ranking
290

Biology and Biochemistry

D-Index
61
Citations
10301
World Ranking
11593
National Ranking
398

Overview

David R. Rose is affiliated with the University of Waterloo in Canada. Their research spans several areas within biochemistry, genetics, and molecular biology, with notable contributions also in the field of medicine. Their work is often situated within the subfields of molecular biology, biotechnology, genetics, nutrition and dietetics, as well as radiology, nuclear medicine, and imaging.

The main topics covered in David R. Rose's research include:

  • Enzyme Production and Characterization
  • Digestive system and related health
  • Studies on Chitinases and Chitosanases
  • Microbial Metabolites in Food Biotechnology
  • Glycosylation and Glycoproteins Research
  • Monoclonal and Polyclonal Antibodies Research
  • Carbohydrate Chemistry and Synthesis

David R. Rose has published research in several scientific journals. Frequent publication venues include:

  • Acta Crystallographica Section A Foundations and Advances
  • Food Chemistry
  • Nature Chemical Biology
  • Acta Crystallographica Section D Structural Biology
  • bioRxiv (Cold Spring Harbor Laboratory)

Among recent papers authored or co-authored by David R. Rose are:

  • "New insights suggest isomaltooligosaccharides are slowly digestible carbohydrates, rather than dietary fibers, at constitutive mammalian α-glucosidase levels" (2022) published in Food Chemistry
  • "Immobilized enzyme cascade for targeted glycosylation" (2024) published in Nature Chemical Biology
  • "Crystal structure of a polyglycine hydrolase determined using a RoseTTAFold model" (2023) published in Acta Crystallographica Section D Structural Biology
  • "Immobilised enzyme cascade for targeted glycosylation" (2022) published in bioRxiv (Cold Spring Harbor Laboratory)
  • "Structural analysis of human intestinal alpha-glucosydases: sucrase-isomaltase and maltase-glucoamylase" (2020) published in Acta Crystallographica Section A Foundations and Advances

Frequent collaborators include Todd A. Naumann, Neil P. J. Price, Elli Makrydaki, Roberto Donini, and A. P. Krueger. These co-authors have worked with David R. Rose on multiple publications, indicating ongoing collaborative research efforts.

Best Publications

  • Indole-3-acetic acid in plant–microbe interactions

    Daiana Duca;Janet Lorv;Cheryl L. Patten;David Rose

  • Human intestinal maltase-glucoamylase: crystal structure of the N-terminal catalytic subunit and basis of inhibition and substrate specificity

    Lyann Sim;Roberto Quezada-Calvillo;Erwin E. Sterchi;Buford L. Nichols

  • Recognition of a cell-surface oligosaccharide of pathogenic Salmonella by an antibody Fab fragment.

    Miroslaw Cygler;David R. Rose;David R. Bundle

  • Structure of yeast triosephosphate isomerase at 1.9-A resolution.

    Elias Lolis;Tom Alber;Robert C. Davenport;David Rose

  • Structure of Golgi α-mannosidase II: A target for inhibition of growth and metastasis of cancer cells

    Jean M.H. van den Elsen;Douglas A. Kuntz;David R. Rose

  • Structural Basis for Substrate Selectivity in Human Maltase-Glucoamylase and Sucrase-Isomaltase N-terminal Domains

    Lyann Sim;Carly Willemsma;Sankar Mohan;Hassan Y. Naim

  • Crystallographic observation of a covalent catalytic intermediate in a beta-glycosidase.

    André White;Dedreia Tull;Kathy Johns;Stephen G. Withers

  • New glucosidase inhibitors from an ayurvedic herbal treatment for type 2 diabetes: structures and inhibition of human intestinal maltase-glucoamylase with compounds from Salacia reticulata.

    L. Sim;Kumarasamy Jayakanthan;Sankar Mohan;Ravindranath Nasi

  • Crystal structure of the catalytic domain of the beta-1,4-glycanase cex from Cellulomonas fimi.

    Andre White;Stephen G. Withers;Neil R. Gilkes;David R. Rose

  • The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma

    G. Wei Xu;Mohsin Ali;Tabitha E. Wood;Tabitha E. Wood;Derek Wong

  • Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes

    Wade Abbott;Orly Alber;Ed Bayer;Jean-Guy Berrin

  • Mechanism of catalysis by retaining β-glycosyl hydrolases

    André White;David R Rose

  • Differential Oligosaccharide Recognition by Evolutionarily-related β-1,4 and β-1,3 Glucan-binding Modules

    Alisdair B. Boraston;Didier Nurizzo;Valerie Notenboom;Valérie Ducros

  • Crystal structures of the family 9 carbohydrate-binding module from Thermotoga maritima xylanase 10A in native and ligand-bound forms.

    Valerie Notenboom;Alisdair B. Boraston;Douglas G. Kilburn;David R. Rose

  • Evidence for the extended helical nature of polysaccharide epitopes. The 2.8 A resolution structure and thermodynamics of ligand binding of an antigen binding fragment specific for alpha-(2-->8)-polysialic acid.

    S.V Evans;B.W Sigurskjold;H.J Jennings;J.R Brisson

  • High-resolution crystal structures of the lectin-like xylan binding domain from Streptomyces lividans xylanase 10A with bound substrates reveal a novel mode of xylan binding.

    Valerie Notenboom;Alisdair B. Boraston;Spencer J. Williams;Douglas G. Kilburn

  • Insights into transition state stabilization of the β-1,4-glycosidase Cex by covalent intermediate accumulation in active site mutants

    Notenboom;Birsan C;Nitz M;Rose Dr

  • Clioquinol inhibits the proteasome and displays preclinical activity in leukemia and myeloma.

    X Mao;X Li;R Sprangers;X Wang

  • Golgi α-mannosidase II cleaves two sugars sequentially in the same catalytic site

    Niket Shah;Douglas A. Kuntz;David R. Rose

  • Multisubstrate Isotope Labeling and Metagenomic Analysis of Active Soil Bacterial Communities

    Y. Verastegui;J. Cheng;K. Engel;D. Kolczynski

  • Insights into the Mechanism of Drosophila melanogaster Golgi α-Mannosidase II through the Structural Analysis of Covalent Reaction Intermediates

    Shin Numao;Douglas A. Kuntz;Stephen G. Withers;David R. Rose;David R. Rose

  • Recognition of cello-oligosaccharides by a family 17 carbohydrate-binding module: an X-ray crystallographic, thermodynamic and mutagenic study.

    Valerie Notenboom;Alisdair B Boraston;Patrick Chiu;Alexander C.J Freelove

Frequent Co-Authors

Buford L. Nichols
Buford L. Nichols Baylor College of Medicine
Bruce R. Hamaker
Bruce R. Hamaker Purdue University West Lafayette
Stephen G. Withers
Stephen G. Withers University of British Columbia
Aaron D. Schimmer
Aaron D. Schimmer Princess Margaret Cancer Centre
Trevor C. Charles
Trevor C. Charles University of Waterloo
Douglas G. Kilburn
Douglas G. Kilburn University of British Columbia
Robert A. Batey
Robert A. Batey University of Toronto
Hassan Y. Naim
Hassan Y. Naim University of Veterinary Medicine Vienna
Josh D. Neufeld
Josh D. Neufeld University of Waterloo
Alisdair B. Boraston
Alisdair B. Boraston University of Victoria

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