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Osamu Muraoka

Osamu Muraoka

D-Index & Metrics

Chemistry

D-Index
43
Citations
7587
World Ranking
17152
National Ranking
1353

Overview

Osamu Muraoka is affiliated with Kindai University in Japan, contributing research primarily in the fields of Biochemistry, Genetics and Molecular Biology, Medicine, and Chemistry. Their scholarly work encompasses molecular biology, organic chemistry, plant science, endocrinology, diabetes and metabolism, and biochemistry.

Their research focuses on several specialized topics including carbohydrate chemistry and synthesis, phytochemical compounds biological activities, natural antidiabetic agents studies, plant-derived lignans synthesis and bioactivity, traditional and medicinal uses of Annonaceae, Pneumocystis jirovecii pneumonia detection and treatment, and natural product bioactivities and synthesis.

Muraoka has published extensively, with notable research appearing in the following venues:

  • Journal of Natural Medicines (4 publications)
  • ChemMedChem (3 publications)
  • Fitoterapia (2 publications)
  • International Journal of Molecular Sciences (2 publications)
  • RSC Advances (2 publications)

Frequent collaborators include Toshio Morikawa, Genzoh Tanabe, Weijia Xie, Kiyofumi Ninomiya, and Masayuki Yoshikawa.

Selected recent papers authored or co-authored by Muraoka include:

  • A review of antidiabetic active thiosugar sulfoniums, salacinol and neokotalanol, from plants of the genus Salacia (2021, Journal of Natural Medicines)
  • Radiation responsive PROTAC nanoparticles for tumor-specific proteolysis enhanced radiotherapy (2024, Journal of Materials Chemistry B)
  • Geranylated Coumarins From Thai Medicinal Plant Mammea siamensis With Testosterone 5α-Reductase Inhibitory Activity (2020, Frontiers in Chemistry)
  • Collagen synthesis-promoting and collagenase inhibitory activities of constituents isolated from the rhizomes of Picrorhiza kurroa Royle ex Benth (2020, Fitoterapia)
  • Design and Synthesis of Sulfonium Derivatives: A Novel Class of α-Glucosidase Inhibitors with Potent In Vivo Antihyperglycemic Activities (2023, Journal of Medicinal Chemistry)

Best Publications

  • Salacinol, potent antidiabetic principle with unique thiosugar sulfonium sulfate structure from the ayurvedic traditional medicine Salacia reticulata in Sri Lanka and India

    Masayuki Yoshikawa;Toshiyuki Murakami;Hiromi Shimada;Hisashi Matsuda

  • Absolute Stereostructure of Potent α-Glucosidase Inhibitor, Salacinol, with Unique Thiosugar Sulfonium Sulfate Inner Salt Structure from Salacia reticulata

    Masayuki Yoshikawa;Toshio Morikawa;Hisashi Matsuda;Genzoh Tanabe

  • Di-tert-butylsilylene (DTBS) group-directed α-selective galactosylation unaffected by C-2 participating functionalities

    Akihiro Imamura;Hiromune Ando;Satomi Korogi;Genzoh Tanabe

  • Acylated phenylethanoid oligoglycosides with hepatoprotective activity from the desert plant Cistanche tubulosa.

    Toshio Morikawa;Yingni Pan;Yingni Pan;Kiyofumi Ninomiya;Katsuya Imura

  • Phenylethanoid oligoglycosides and acylated oligosugars with vasorelaxant activity from Cistanche tubulosa.

    Masayuki Yoshikawa;Hisashi Matsuda;Toshio Morikawa;Toshio Morikawa;Haihui Xie

  • Alkaloid constituents from flower buds and leaves of sacred lotus (Nelumbo nucifera, Nymphaeaceae) with melanogenesis inhibitory activity in B16 melanoma cells

    Seikou Nakamura;Souichi Nakashima;Genzo Tanabe;Yoshimi Oda

  • Salaprionol and Ponkoranol with Thiosugar Sulfonium Sulfate Structure from Salacia prinoides and a-Glucosidase Inhibitory Activity of Ponkoranol and Kotalanol Desulfate

    Masayuki Yoshikawa;Fengming Xu;Seikou Nakamura;Tao Wang

  • Isolation, structure identification and SAR studies on thiosugar sulfonium salts, neosalaprinol and neoponkoranol, as potent α-glucosidase inhibitors.

    Weijia Xie;Genzoh Tanabe;Junji Akaki;Toshio Morikawa

  • Biological evaluation of de-O-sulfonated analogs of salacinol, the role of sulfate anion in the side chain on the α-glucosidase inhibitory activity

    Genzoh Tanabe;Kazuya Yoshikai;Takanori Hatanaka;Mizuho Yamamoto

  • Absolute stereostructures of novel norcadinane- and trinoreudesmane-type sesquiterpenes with nitric oxide production inhibitory activity from Alpinia oxyphylla.

    Osamu Muraoka;Manabu Fujimoto;Genzoh Tanabe;Michinori Kubo

  • Acylated phenylethanoid glycosides, echinacoside and acteoside from Cistanche tubulosa, improve glucose tolerance in mice

    Toshio Morikawa;Kiyofumi Ninomiya;Mio Imamura;Junji Akaki

  • Hepatoprotective triterpenes from traditional Tibetan medicine Potentilla anserina.

    Toshio Morikawa;Kiyofumi Ninomiya;Katsuya Imura;Takahiro Yamaguchi

  • On the structure of the bioactive constituent from ayurvedic medicine Salacia reticulata: revision of the literature

    Osamu Muraoka;Weijia Xie;Genzoh Tanabe;Mumen F.A. Amer

  • Oleanane-type triterpene oligoglycosides with pancreatic lipase inhibitory activity from the pericarps of Sapindus rarak

    Toshio Morikawa;Yuanyuan Xie;Yuanyuan Xie;Yasunobu Asao;Masaki Okamoto

  • Inhibitors of Nitric Oxide Production from the Rhizomes of Alpinia galanga: Structures of New 8–9′ Linked Neolignans and Sesquineolignan

    Toshio Morikawa;Shin Ando;Hisashi Matsuda;Shinya Kataoka

  • Bioactive constituents from Chinese natural medicines. XXII. Absolute structures of new megastigmane glycosides, sedumosides E1, E2, E3, F1, F2, and G, from Sedum sarmentosum (Crassulaceae).

    Toshio Morikawa;Toshio Morikawa;Yi Zhang;Seikou Nakamura;Hisashi Matsuda

  • Monoterpene constituents from Cistanche tubulosa--chemical structures of kankanosides A-E and kankanol-.

    Haihui Xie;Toshio Morikawa;Toshio Morikawa;Hisashi Matsuda;Seikou Nakamura

  • Total synthesis of (+/-)-stemonamide and (+/-)-isostemonamide using a radical cascade.

    Tsuyoshi Taniguchi;Genzo Tanabe;Osamu Muraoka;Hiroyuki Ishibashi

  • Bioactive constituents from Chinese natural medicines. XXIII. Absolute structures of new megastigmane glycosides, sedumosides A(4), A(5), A(6), H, and I, and hepatoprotective megastigmanes from Sedum sarmentosum.

    Kiyofumi Ninomiya;Kiyofumi Ninomiya;Toshio Morikawa;Toshio Morikawa;Yi Zhang;Seikou Nakamura

  • 7-endo selective aryl radical cyclization onto enamides leading to 3-benzazepines: concise construction of a cephalotaxine skeleton.

    Tsuyoshi Taniguchi;Atsuko Ishita;Masahiko Uchiyama;Osamu Tamura

  • Synthesis and biological evaluation of deoxy salacinols, the role of polar substituents in the side chain on the α-glucosidase inhibitory activity

    Osamu Muraoka;Kazuya Yoshikai;Hideo Takahashi;Toshie Minematsu

  • Bioactive Saponins and Glycosides. XXVIII. New Triterpene Saponins, Foliatheasaponins I, II, III, IV, and V, from Tencha (the Leaves of Camellia sinensis)

    Toshio Morikawa;Toshio Morikawa;Seikou Nakamura;Yasuyo Kato;Osamu Muraoka

Frequent Co-Authors

Toshio Morikawa
Toshio Morikawa Kindai University
Masayuki Yoshikawa
Masayuki Yoshikawa Kyoto Pharmaceutical University
Hisashi Matsuda
Hisashi Matsuda Kyoto Pharmaceutical University
Seikou Nakamura
Seikou Nakamura Kyoto Pharmaceutical University
Jinyi Xu
Jinyi Xu China Pharmaceutical University
Hiroshi Shimizu
Hiroshi Shimizu Hokkaido University
Kiyoshi Tomioka
Kiyoshi Tomioka Doshisha Women's College of Liberal Arts
Hequan Yao
Hequan Yao China Pharmaceutical University
Munekazu Iinuma
Munekazu Iinuma Gifu Pharmaceutical University
Makoto Kiso
Makoto Kiso Gifu University

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