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Herman S. Overkleeft

Herman S. Overkleeft

Leiden University
Netherlands

Award Badge
Chemistry
Netherlands
2025

D-Index & Metrics

Biology and Biochemistry

D-Index
86
Citations
27503
World Ranking
2951
National Ranking
76

Chemistry

D-Index
85
Citations
27255
World Ranking
2655
National Ranking
64

Herman S. Overkleeft publication distribution in Chemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Chemistry in 2026. The highlighted bar marks where Herman S. Overkleeft sits on this spectrum.

61–80 publications: 66 scientists 81–100 publications: 302 scientists 101–120 publications: 623 scientists 121–140 publications: 918 scientists 141–160 publications: 1,218 scientists 161–180 publications: 1,350 scientists 181–200 publications: 1,344 scientists 201–220 publications: 1,281 scientists 221–240 publications: 1,216 scientists 241–260 publications: 1,100 scientists 261–280 publications: 979 scientists 281–300 publications: 939 scientists 301–320 publications: 764 scientists 321–340 publications: 643 scientists 341–360 publications: 628 scientists 361–380 publications: 522 scientists 381–400 publications: 459 scientists 401–420 publications: 397 scientists 421–440 publications: 327 scientists 441–460 publications: 270 scientists 461–480 publications: 265 scientists 481–500 publications: 252 scientists 501–520 publications: 201 scientists 521–540 publications: 185 scientists 541–560 publications: 148 scientists 561–580 publications: 148 scientists 581–600 publications: 132 scientists 601–620 publications: 114 scientists 621–640 publications: 104 scientists 641–660 publications: 91 scientists 661–680 publications: 92 scientists 681–700 publications: 73 scientists 701–720 publications: 57 scientists 721–740 publications: 54 scientists 741–760 publications: 67 scientists 761–780 publications: 45 scientists 781–800 publications: 46 scientists 801–820 publications: 39 scientists 821–840 publications: 32 scientists 841–860 publications: 36 scientists 861–880 publications: 29 scientists 881–900 publications: 26 scientists 901–920 publications: 24 scientists 921–940 publications: 14 scientists 941–960 publications: 23 scientists 961–980 publications: 28 scientists 981–1,000 publications: 15 scientists 1,001–1,020 publications: 29 scientists 1,021–1,040 publications: 12 scientists 1,041–1,060 publications: 19 scientists 1,061–1,080 publications: 12 scientists 1,081–1,100 publications: 6 scientists 1,101–1,120 publications: 8 scientists 1,121–1,140 publications: 12 scientists 1,141–1,160 publications: 5 scientists 1,161–1,180 publications: 6 scientists 1,181–1,200 publications: 14 scientists 1,201–1,220 publications: 7 scientists 1,221–1,240 publications: 2 scientists 1,241–1,260 publications: 6 scientists 1,261–1,280 publications: 4 scientists 1,281–1,294 publications: 6 scientists 1,295+ publications: 100 scientists
61 publications 1,295+

This scientist: 608 publications — 93rd percentile

93% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,295 publications or more.

Herman S. Overkleeft D-index placement in Chemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Chemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Herman S. Overkleeft sits on this spectrum.

40–41 D-Index: 289 scientists 42–43 D-Index: 612 scientists 44–45 D-Index: 808 scientists 46–47 D-Index: 776 scientists 48–49 D-Index: 835 scientists 50–51 D-Index: 861 scientists 52–53 D-Index: 872 scientists 54–55 D-Index: 933 scientists 56–57 D-Index: 1,051 scientists 58–59 D-Index: 930 scientists 60–61 D-Index: 882 scientists 62–63 D-Index: 834 scientists 64–65 D-Index: 731 scientists 66–67 D-Index: 775 scientists 68–69 D-Index: 683 scientists 70–71 D-Index: 646 scientists 72–73 D-Index: 561 scientists 74–75 D-Index: 501 scientists 76–77 D-Index: 437 scientists 78–79 D-Index: 388 scientists 80–81 D-Index: 354 scientists 82–83 D-Index: 292 scientists 84–85 D-Index: 275 scientists 86–87 D-Index: 254 scientists 88–89 D-Index: 235 scientists 90–91 D-Index: 185 scientists 92–93 D-Index: 192 scientists 94–95 D-Index: 155 scientists 96–97 D-Index: 163 scientists 98–99 D-Index: 125 scientists 100–101 D-Index: 105 scientists 102–103 D-Index: 105 scientists 104–105 D-Index: 112 scientists 106–107 D-Index: 88 scientists 108–109 D-Index: 68 scientists 110–111 D-Index: 69 scientists 112–113 D-Index: 65 scientists 114–115 D-Index: 79 scientists 116–117 D-Index: 61 scientists 118–119 D-Index: 44 scientists 120–121 D-Index: 37 scientists 122–123 D-Index: 40 scientists 124–125 D-Index: 33 scientists 126–127 D-Index: 26 scientists 128–129 D-Index: 34 scientists 130–131 D-Index: 35 scientists 132–133 D-Index: 25 scientists 134–135 D-Index: 27 scientists 136–137 D-Index: 17 scientists 138–139 D-Index: 16 scientists 140–141 D-Index: 20 scientists 142–143 D-Index: 20 scientists 144–145 D-Index: 15 scientists 146–147 D-Index: 9 scientists 148–149 D-Index: 9 scientists 150–151 D-Index: 16 scientists 152–153 D-Index: 11 scientists 154–155 D-Index: 9 scientists 156–157 D-Index: 3 scientists 158 D-Index: 3 scientists 159+ D-Index: 98 scientists
40 D-Index 159+

This scientist: 85 D-Index — 85th percentile

85% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 159 D-Index or more.

Research.com Recognitions

  • 2025 - Research.com Chemistry in Netherlands Leader Award
  • 2022 - Research.com Chemistry in Netherlands Leader Award

Overview

Herman S. Overkleeft is affiliated with Leiden University in the Netherlands and has an extensive body of work primarily situated in the fields of Biochemistry, Genetics and Molecular Biology as well as Medicine. Their research focuses on molecular biology and organic chemistry, with additional contributions to physiology, biotechnology, and oncology.

The scientist's main research topics include:

  • Carbohydrate Chemistry and Synthesis
  • Glycosylation and Glycoproteins Research
  • Enzyme Production and Characterization
  • Lysosomal Storage Disorders Research
  • Calcium signaling and nucleotide metabolism
  • Chemical Synthesis and Analysis
  • Click Chemistry and Applications

Overkleeft has published numerous papers in frequent venues such as:

  • Journal of the American Chemical Society
  • ChemBioChem
  • Angewandte Chemie International Edition
  • Chemistry - A European Journal
  • Angewandte Chemie

Recent publications illustrate the range and focus of their research:

  • Uncoupling DNA damage from chromatin damage to detoxify doxorubicin, 2020, Proceedings of the National Academy of Sciences
  • Plant Glycosides and Glycosidases: A Treasure-Trove for Therapeutics, 2020, Frontiers in Plant Science
  • Characterization of glycosyl dioxolenium ions and their role in glycosylation reactions, 2020, Nature Communications
  • Fabry Disease: Molecular Basis, Pathophysiology, Diagnostics and Potential Therapeutic Directions, 2021, Biomolecules
  • The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Mediated Immune Responses, 2020, Immunity

Collaborative efforts form a significant part of Overkleeft's research output. Frequent co-authors include:

  • Jeroen D. C. Codée
  • G.J. Davies
  • Gijsbert A. van der Marel
  • Johannes M. F. G. Aerts
  • Dmitri V. Filippov

Best Publications

  • Proteasome Inhibitors: An Expanding Army Attacking a Unique Target

    Alexei F. Kisselev;Wouter A. van der Linden;Herman S. Overkleeft

  • A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14.

    Anna Borodovsky;Benedikt M. Kessler;Rocco Casagrande;Herman S. Overkleeft

  • Thioglycosides in sequential glycosylation strategies

    Jeroen D. C. Codée;Remy E. J. N. Litjens;Leendert J. van den Bos;Herman S. Overkleeft

  • Glycosphingolipids—Nature, Function, and Pharmacological Modulation

    Tom Wennekes;Richard J. B. H. N. van den Berg;Rolf G. Boot;Gijsbert A. van der Marel

  • Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474

    Annelot C. M. van Esbroeck;Antonius P. A. Janssen;Armand B. Cognetta;Daisuke Ogasawara

  • Elevated plasma glucosylsphingosine in Gaucher disease: relation to phenotype, storage cell markers, and therapeutic response

    Nick Dekker;Laura van Dussen;Carla E. M. Hollak;Herman Overkleeft

  • Ultrasensitive in situ visualization of active glucocerebrosidase molecules

    Martin D Witte;Wouter W Kallemeijn;Jan Aten;Kah-Yee Li

  • Ph2SO/Tf2O: a powerful promotor system in chemoselective glycosylations using thioglycosides.

    Jeroen D C Codée;Remy E J N Litjens;René den Heeten;Herman S Overkleeft

  • Analysis of Protease Activity in Live Antigen-presenting Cells Shows Regulation of the Phagosomal Proteolytic Contents During Dendritic Cell Activation

    Ana Maria Lennon-Duménil;Arnold H. Bakker;René Maehr;Edda Fiebiger

  • Generation of Specific Deoxynojirimycin-type Inhibitors of the Non-lysosomal Glucosylceramidase

    Herman S. Overkleeft;G. Herma Renkema;Jolanda Neele;Paula Vianello

  • Muscle Wasting in Aged, Sarcopenic Rats Is Associated with Enhanced Activity of the Ubiquitin Proteasome Pathway

    Mikael Altun;Mikael Altun;Henrike C. Besche;Herman S. Overkleeft;Rosanna Piccirillo

  • The Caspase-like Sites of Proteasomes, Their Substrate Specificity, New Inhibitors and Substrates, and Allosteric Interactions with the Trypsin-like Sites *

    Alexei F. Kisselev;Margarita Garcia-Calvo;Herman S. Overkleeft;Erin Peterson

  • Asymmetric Proteasome Segregation as a Mechanism for Unequal Partitioning of the Transcription Factor T-bet during T Lymphocyte Division

    John T. Chang;Maria L. Ciocca;Ichiko Kinjyo;Vikram R. Palanivel

  • A Fluorescent Broad-Spectrum Proteasome Inhibitor for Labeling Proteasomes In Vitro and In Vivo

    Martijn Verdoes;Bogdan I. Florea;Victoria Menendez-Benito;Christa J. Maynard

  • Chemistry in Living Cells: Detection of Active Proteasomes by a Two‐Step Labeling Strategy

    Huib Ovaa;Paul F. van Swieten;Benedikt M. Kessler;Michiel A. Leeuwenburgh

  • Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic β-subunits

    Benedikt M Kessler;Domenico Tortorella;Mikael Altun;Alexei F Kisselev

  • Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition

    Daisuke Ogasawara;Hui Deng;Andreu Viader;Marc P. Baggelaar

  • Selective inhibitor of proteasome's caspase-like sites sensitizes cells to specific inhibition of chymotrypsin-like sites.

    Matthew Britton;Marcella M. Lucas;Marcella M. Lucas;Sondra L. Downey;Michael Screen;Michael Screen

  • A modular strategy toward the synthesis of heparin-like oligosaccharides using monomeric building blocks in a sequential glycosylation strategy.

    Jeroen D. C. Codée;Bas Stubba;Marialuisa Schiattarella;Herman S. Overkleeft

  • Characterization of the ubiquitin-proteasome system in bortezomib-adapted cells.

    T Rückrich;M Kraus;J Gogel;A Beck

  • Thioglycuronides: synthesis and application in the assembly of acidic oligosaccharides.

    Leendert J van den Bos;Jeroen D C Codée;John C van der Toorn;Thomas J Boltje

Frequent Co-Authors

Jeroen D. C. Codée
Jeroen D. C. Codée Leiden University
Johannes M. F. G. Aerts
Johannes M. F. G. Aerts Leiden University
Christoph Driessen
Christoph Driessen University of St. Gallen
Rolf G. Boot
Rolf G. Boot Leiden University
Gideon J. Davies
Gideon J. Davies University of York
Huib Ovaa
Huib Ovaa Leiden University Medical Center
Ferry Ossendorp
Ferry Ossendorp Leiden University Medical Center
Benedikt M. Kessler
Benedikt M. Kessler University of Oxford
G. A. Van Der Marel
G. A. Van Der Marel Leiden University
Hidde L. Ploegh
Hidde L. Ploegh Boston Children's Hospital

External Links

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Best Scientists Citing Herman S. Overkleeft

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Publications: 46

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Publications: 44

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Publications: 44

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Publications: 41

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University of Oxford

Publications: 39

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Publications: 37

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Publications: 36

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Publications: 33

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