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Herman S. Overkleeft

Herman S. Overkleeft

Leiden University
Netherlands

Award Badge
Chemistry
Netherlands
2025

D-Index & Metrics

Discipline name D-Index World Ranking Current World Ranking National Ranking Current National Ranking Publications Citations
Chemistry 85 2655 2392 64 54 608 27255
Biology and Biochemistry 86 2950 2713 76 71 613 27503

Herman S. Overkleeft publications per year

The chart shows the history of publications by Herman S. Overkleeft between 1993 and 2025, highlighting the no. of papers published in each year and offering an overview of the publication velocity of this scholar. Herman S. Overkleeft published across 33 years, from 1993 to 2025, averaging 22 papers a year. Output peaked at 48 publications in 2017. 30 of the 726 publications appeared in the last two years.

No. of publications
10 20 30 40
Bar chart. Horizontal axis: year, 1993 to 2025. Vertical axis: number of publications, 0 to 48. Peak 48 publications in 2017. 1993: 1 publication 1994: 2 publications 1995: 0 publications 1996: 1 publication 1997: 4 publications 1998: 7 publications 1999: 9 publications 2000: 7 publications 2001: 5 publications 2002: 11 publications 2003: 24 publications 2004: 25 publications 2005: 24 publications 2006: 14 publications 2007: 24 publications 2008: 17 publications 2009: 32 publications 2010: 31 publications 2011: 33 publications 2012: 36 publications 2013: 20 publications 2014: 35 publications 2015: 35 publications 2016: 36 publications 2017: 48 publications 2018: 30 publications 2019: 41 publications 2020: 32 publications 2021: 29 publications 2022: 41 publications 2023: 42 publications 2024: 20 publications 2025: 10 publications
1993 2025

726 publications in total across all disciplines

View publications per year as a table
Herman S. Overkleeft: publications per year, 1993 to 2025
Year Publications
1993 1
1994 2
1995 0
1996 1
1997 4
1998 7
1999 9
2000 7
2001 5
2002 11
2003 24
2004 25
2005 24
2006 14
2007 24
2008 17
2009 32
2010 31
2011 33
2012 36
2013 20
2014 35
2015 35
2016 36
2017 48
2018 30
2019 41
2020 32
2021 29
2022 41
2023 42
2024 20
2025 10
Total 726
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Herman S. Overkleeft publication distribution in Chemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Chemistry in 2026. The highlighted bar marks where Herman S. Overkleeft sits on this spectrum.

No. of scientists
250 500 750 1,000 1,250
Bar chart with 63 bars. Horizontal axis: publications, 61–80 to 1,295+. Vertical axis: number of scientists, 0 to 1,350. Most scientists, 1,350, have 161–180 publications. The last bar groups every scientist with 1,295 publications or more. The highlighted bar, 601–620 publications, is where this scientist sits. 61–80 publications: 66 scientists 81–100 publications: 302 scientists 101–120 publications: 623 scientists 121–140 publications: 918 scientists 141–160 publications: 1,218 scientists 161–180 publications: 1,350 scientists 181–200 publications: 1,344 scientists 201–220 publications: 1,281 scientists 221–240 publications: 1,216 scientists 241–260 publications: 1,100 scientists 261–280 publications: 979 scientists 281–300 publications: 939 scientists 301–320 publications: 764 scientists 321–340 publications: 643 scientists 341–360 publications: 628 scientists 361–380 publications: 522 scientists 381–400 publications: 459 scientists 401–420 publications: 397 scientists 421–440 publications: 327 scientists 441–460 publications: 270 scientists 461–480 publications: 265 scientists 481–500 publications: 252 scientists 501–520 publications: 201 scientists 521–540 publications: 185 scientists 541–560 publications: 148 scientists 561–580 publications: 148 scientists 581–600 publications: 132 scientists 601–620 publications: 114 scientists 621–640 publications: 104 scientists 641–660 publications: 91 scientists 661–680 publications: 92 scientists 681–700 publications: 73 scientists 701–720 publications: 57 scientists 721–740 publications: 54 scientists 741–760 publications: 67 scientists 761–780 publications: 45 scientists 781–800 publications: 46 scientists 801–820 publications: 39 scientists 821–840 publications: 32 scientists 841–860 publications: 36 scientists 861–880 publications: 29 scientists 881–900 publications: 26 scientists 901–920 publications: 24 scientists 921–940 publications: 14 scientists 941–960 publications: 23 scientists 961–980 publications: 28 scientists 981–1,000 publications: 15 scientists 1,001–1,020 publications: 29 scientists 1,021–1,040 publications: 12 scientists 1,041–1,060 publications: 19 scientists 1,061–1,080 publications: 12 scientists 1,081–1,100 publications: 6 scientists 1,101–1,120 publications: 8 scientists 1,121–1,140 publications: 12 scientists 1,141–1,160 publications: 5 scientists 1,161–1,180 publications: 6 scientists 1,181–1,200 publications: 14 scientists 1,201–1,220 publications: 7 scientists 1,221–1,240 publications: 2 scientists 1,241–1,260 publications: 6 scientists 1,261–1,280 publications: 4 scientists 1,281–1,294 publications: 6 scientists 1,295+ publications: 100 scientists
61–80 publications 1,295+

This scientist: 608 publications — 93rd percentile

93% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,295 publications or more.

View publications distribution as a table
Number of Chemistry scientists by publication count, Research.com 2026 ranking edition. Based on 17,934 ranked scientists.
Publications Scientists This scientist
61–80 66
81–100 302
101–120 623
121–140 918
141–160 1,218
161–180 1,350
181–200 1,344
201–220 1,281
221–240 1,216
241–260 1,100
261–280 979
281–300 939
301–320 764
321–340 643
341–360 628
361–380 522
381–400 459
401–420 397
421–440 327
441–460 270
461–480 265
481–500 252
501–520 201
521–540 185
541–560 148
561–580 148
581–600 132
601–620 114 608
621–640 104
641–660 91
661–680 92
681–700 73
701–720 57
721–740 54
741–760 67
761–780 45
781–800 46
801–820 39
821–840 32
841–860 36
861–880 29
881–900 26
901–920 24
921–940 14
941–960 23
961–980 28
981–1,000 15
1,001–1,020 29
1,021–1,040 12
1,041–1,060 19
1,061–1,080 12
1,081–1,100 6
1,101–1,120 8
1,121–1,140 12
1,141–1,160 5
1,161–1,180 6
1,181–1,200 14
1,201–1,220 7
1,221–1,240 2
1,241–1,260 6
1,261–1,280 4
1,281–1,294 6
1,295+ 100
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Herman S. Overkleeft D-index placement in Chemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Chemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Herman S. Overkleeft sits on this spectrum.

No. of scientists
250 500 750 1,000
Bar chart with 61 bars. Horizontal axis: D-Index, 40–41 to 159+. Vertical axis: number of scientists, 0 to 1,051. Most scientists, 1,051, have 56–57 D-Index. The last bar groups every scientist with 159 D-Index or more. The highlighted bar, 84–85 D-Index, is where this scientist sits. 40–41 D-Index: 289 scientists 42–43 D-Index: 612 scientists 44–45 D-Index: 808 scientists 46–47 D-Index: 776 scientists 48–49 D-Index: 835 scientists 50–51 D-Index: 861 scientists 52–53 D-Index: 872 scientists 54–55 D-Index: 933 scientists 56–57 D-Index: 1,051 scientists 58–59 D-Index: 930 scientists 60–61 D-Index: 882 scientists 62–63 D-Index: 834 scientists 64–65 D-Index: 731 scientists 66–67 D-Index: 775 scientists 68–69 D-Index: 683 scientists 70–71 D-Index: 646 scientists 72–73 D-Index: 561 scientists 74–75 D-Index: 501 scientists 76–77 D-Index: 437 scientists 78–79 D-Index: 388 scientists 80–81 D-Index: 354 scientists 82–83 D-Index: 292 scientists 84–85 D-Index: 275 scientists 86–87 D-Index: 254 scientists 88–89 D-Index: 235 scientists 90–91 D-Index: 185 scientists 92–93 D-Index: 192 scientists 94–95 D-Index: 155 scientists 96–97 D-Index: 163 scientists 98–99 D-Index: 125 scientists 100–101 D-Index: 105 scientists 102–103 D-Index: 105 scientists 104–105 D-Index: 112 scientists 106–107 D-Index: 88 scientists 108–109 D-Index: 68 scientists 110–111 D-Index: 69 scientists 112–113 D-Index: 65 scientists 114–115 D-Index: 79 scientists 116–117 D-Index: 61 scientists 118–119 D-Index: 44 scientists 120–121 D-Index: 37 scientists 122–123 D-Index: 40 scientists 124–125 D-Index: 33 scientists 126–127 D-Index: 26 scientists 128–129 D-Index: 34 scientists 130–131 D-Index: 35 scientists 132–133 D-Index: 25 scientists 134–135 D-Index: 27 scientists 136–137 D-Index: 17 scientists 138–139 D-Index: 16 scientists 140–141 D-Index: 20 scientists 142–143 D-Index: 20 scientists 144–145 D-Index: 15 scientists 146–147 D-Index: 9 scientists 148–149 D-Index: 9 scientists 150–151 D-Index: 16 scientists 152–153 D-Index: 11 scientists 154–155 D-Index: 9 scientists 156–157 D-Index: 3 scientists 158 D-Index: 3 scientists 159+ D-Index: 98 scientists
40–41 D-Index 159+

This scientist: 85 D-Index — 85th percentile

85% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 159 D-Index or more.

View D-Index distribution as a table
Number of Chemistry scientists by D-index, Research.com 2026 ranking edition. Based on 17,934 ranked scientists.
D-Index Scientists This scientist
40–41 289
42–43 612
44–45 808
46–47 776
48–49 835
50–51 861
52–53 872
54–55 933
56–57 1,051
58–59 930
60–61 882
62–63 834
64–65 731
66–67 775
68–69 683
70–71 646
72–73 561
74–75 501
76–77 437
78–79 388
80–81 354
82–83 292
84–85 275 85
86–87 254
88–89 235
90–91 185
92–93 192
94–95 155
96–97 163
98–99 125
100–101 105
102–103 105
104–105 112
106–107 88
108–109 68
110–111 69
112–113 65
114–115 79
116–117 61
118–119 44
120–121 37
122–123 40
124–125 33
126–127 26
128–129 34
130–131 35
132–133 25
134–135 27
136–137 17
138–139 16
140–141 20
142–143 20
144–145 15
146–147 9
148–149 9
150–151 16
152–153 11
154–155 9
156–157 3
158 3
159+ 98
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Research.com Recognitions

  • 2025 - Research.com Chemistry in Netherlands Leader Award
  • 2022 - Research.com Chemistry in Netherlands Leader Award

Overview

Herman S. Overkleeft is affiliated with Leiden University in the Netherlands and has an extensive body of work primarily situated in the fields of Biochemistry, Genetics and Molecular Biology as well as Medicine. Their research focuses on molecular biology and organic chemistry, with additional contributions to physiology, biotechnology, and oncology.

The scientist's main research topics include:

  • Carbohydrate Chemistry and Synthesis
  • Glycosylation and Glycoproteins Research
  • Enzyme Production and Characterization
  • Lysosomal Storage Disorders Research
  • Calcium signaling and nucleotide metabolism
  • Chemical Synthesis and Analysis
  • Click Chemistry and Applications

Overkleeft has published numerous papers in frequent venues such as:

  • Journal of the American Chemical Society
  • ChemBioChem
  • Angewandte Chemie International Edition
  • Chemistry - A European Journal
  • Angewandte Chemie

Recent publications illustrate the range and focus of their research:

  • Uncoupling DNA damage from chromatin damage to detoxify doxorubicin, 2020, Proceedings of the National Academy of Sciences
  • Plant Glycosides and Glycosidases: A Treasure-Trove for Therapeutics, 2020, Frontiers in Plant Science
  • Characterization of glycosyl dioxolenium ions and their role in glycosylation reactions, 2020, Nature Communications
  • Fabry Disease: Molecular Basis, Pathophysiology, Diagnostics and Potential Therapeutic Directions, 2021, Biomolecules
  • The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Mediated Immune Responses, 2020, Immunity

Collaborative efforts form a significant part of Overkleeft's research output. Frequent co-authors include:

  • Jeroen D. C. Codée
  • G.J. Davies
  • Gijsbert A. van der Marel
  • Johannes M. F. G. Aerts
  • Dmitri V. Filippov

Best Publications

  • Proteasome Inhibitors: An Expanding Army Attacking a Unique Target

    Alexei F. Kisselev;Wouter A. van der Linden;Herman S. Overkleeft

  • A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14.

    Anna Borodovsky;Benedikt M. Kessler;Rocco Casagrande;Herman S. Overkleeft

  • Thioglycosides in sequential glycosylation strategies

    Jeroen D. C. Codée;Remy E. J. N. Litjens;Leendert J. van den Bos;Herman S. Overkleeft

  • Glycosphingolipids—Nature, Function, and Pharmacological Modulation

    Tom Wennekes;Richard J. B. H. N. van den Berg;Rolf G. Boot;Gijsbert A. van der Marel

  • Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474

    Annelot C. M. van Esbroeck;Antonius P. A. Janssen;Armand B. Cognetta;Daisuke Ogasawara

  • Elevated plasma glucosylsphingosine in Gaucher disease: relation to phenotype, storage cell markers, and therapeutic response

    Nick Dekker;Laura van Dussen;Carla E. M. Hollak;Herman Overkleeft

  • Ultrasensitive in situ visualization of active glucocerebrosidase molecules

    Martin D Witte;Wouter W Kallemeijn;Jan Aten;Kah-Yee Li

  • Ph2SO/Tf2O: a powerful promotor system in chemoselective glycosylations using thioglycosides.

    Jeroen D C Codée;Remy E J N Litjens;René den Heeten;Herman S Overkleeft

  • Analysis of Protease Activity in Live Antigen-presenting Cells Shows Regulation of the Phagosomal Proteolytic Contents During Dendritic Cell Activation

    Ana Maria Lennon-Duménil;Arnold H. Bakker;René Maehr;Edda Fiebiger

  • Generation of Specific Deoxynojirimycin-type Inhibitors of the Non-lysosomal Glucosylceramidase

    Herman S. Overkleeft;G. Herma Renkema;Jolanda Neele;Paula Vianello

  • Muscle Wasting in Aged, Sarcopenic Rats Is Associated with Enhanced Activity of the Ubiquitin Proteasome Pathway

    Mikael Altun;Mikael Altun;Henrike C. Besche;Herman S. Overkleeft;Rosanna Piccirillo

  • The Caspase-like Sites of Proteasomes, Their Substrate Specificity, New Inhibitors and Substrates, and Allosteric Interactions with the Trypsin-like Sites *

    Alexei F. Kisselev;Margarita Garcia-Calvo;Herman S. Overkleeft;Erin Peterson

  • Asymmetric Proteasome Segregation as a Mechanism for Unequal Partitioning of the Transcription Factor T-bet during T Lymphocyte Division

    John T. Chang;Maria L. Ciocca;Ichiko Kinjyo;Vikram R. Palanivel

  • A Fluorescent Broad-Spectrum Proteasome Inhibitor for Labeling Proteasomes In Vitro and In Vivo

    Martijn Verdoes;Bogdan I. Florea;Victoria Menendez-Benito;Christa J. Maynard

  • Chemistry in Living Cells: Detection of Active Proteasomes by a Two‐Step Labeling Strategy

    Huib Ovaa;Paul F. van Swieten;Benedikt M. Kessler;Michiel A. Leeuwenburgh

  • Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic β-subunits

    Benedikt M Kessler;Domenico Tortorella;Mikael Altun;Alexei F Kisselev

  • Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition

    Daisuke Ogasawara;Hui Deng;Andreu Viader;Marc P. Baggelaar

  • Selective inhibitor of proteasome's caspase-like sites sensitizes cells to specific inhibition of chymotrypsin-like sites.

    Matthew Britton;Marcella M. Lucas;Marcella M. Lucas;Sondra L. Downey;Michael Screen;Michael Screen

  • A modular strategy toward the synthesis of heparin-like oligosaccharides using monomeric building blocks in a sequential glycosylation strategy.

    Jeroen D. C. Codée;Bas Stubba;Marialuisa Schiattarella;Herman S. Overkleeft

  • Characterization of the ubiquitin-proteasome system in bortezomib-adapted cells.

    T Rückrich;M Kraus;J Gogel;A Beck

  • Thioglycuronides: synthesis and application in the assembly of acidic oligosaccharides.

    Leendert J van den Bos;Jeroen D C Codée;John C van der Toorn;Thomas J Boltje

Frequent Co-Authors

Jeroen D. C. Codée
Jeroen D. C. Codée Leiden University
Johannes M. F. G. Aerts
Johannes M. F. G. Aerts Leiden University
Christoph Driessen
Christoph Driessen University of St. Gallen
Rolf G. Boot
Rolf G. Boot Leiden University
Gideon J. Davies
Gideon J. Davies University of York
Huib Ovaa
Huib Ovaa Leiden University Medical Center
Ferry Ossendorp
Ferry Ossendorp Leiden University Medical Center
Benedikt M. Kessler
Benedikt M. Kessler University of Oxford
G. A. Van Der Marel
G. A. Van Der Marel Leiden University
Hidde L. Ploegh
Hidde L. Ploegh Boston Children's Hospital

External Links

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Best Scientists Citing Herman S. Overkleeft

Peter H. Seeberger

Peter H. Seeberger

Max Planck Society

Publications: 83

Johannes M. F. G. Aerts

Johannes M. F. G. Aerts

Leiden University

Publications: 64

Huib Ovaa

Huib Ovaa

Leiden University Medical Center

Publications: 57

Matthew Bogyo

Matthew Bogyo

Stanford University

Publications: 55

David Crich

David Crich

University of Georgia

Publications: 54

Alexei V. Demchenko

Alexei V. Demchenko

Saint Louis University

Publications: 47

Renier A. L. van der Hoorn

Renier A. L. van der Hoorn

University of Oxford

Publications: 46

Hidde L. Ploegh

Hidde L. Ploegh

Boston Children's Hospital

Publications: 44

Michael Groll

Michael Groll

Technical University of Munich

Publications: 44

Jeroen D. C. Codée

Jeroen D. C. Codée

Leiden University

Publications: 41

George W. J. Fleet

George W. J. Fleet

University of Oxford

Publications: 39

Benjamin F. Cravatt

Benjamin F. Cravatt

Scripps Research Institute

Publications: 37

Chi-Huey Wong

Chi-Huey Wong

Scripps Research Institute

Publications: 36

Gilles P. van Wezel

Gilles P. van Wezel

Leiden University

Publications: 33

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Christoph Driessen

University of St. Gallen

Publications: 33

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Benedikt M. Kessler

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Publications: 33

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