What is he best known for?
The fields of study he is best known for:
- Enzyme
- Gene
- Organic chemistry
Herman S. Overkleeft mainly focuses on Biochemistry, Proteasome, Stereochemistry, Organic chemistry and Glycosylation.
His studies link Cell culture with Biochemistry.
He combines subjects such as Cancer research, Ubiquitin, Protein degradation, Protein subunit and Bortezomib with his study of Proteasome.
Cycloaddition is closely connected to Chemical synthesis in his research, which is encompassed under the umbrella topic of Stereochemistry.
His study looks at the intersection of Organic chemistry and topics like Combinatorial chemistry with Solid-phase synthesis and Proteomics.
Herman S. Overkleeft works mostly in the field of Glycosylation, limiting it down to concerns involving Uronic acid and, occasionally, Oligosaccharide.
His most cited work include:
- A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14. (405 citations)
- Proteasome Inhibitors: An Expanding Army Attacking a Unique Target (385 citations)
- Thioglycosides in sequential glycosylation strategies (210 citations)
What are the main themes of his work throughout his whole career to date?
Herman S. Overkleeft mostly deals with Stereochemistry, Biochemistry, Organic chemistry, Proteasome and Combinatorial chemistry.
His Stereochemistry research includes themes of Amino acid, Glycosylation, Chemical synthesis, Peptide and Stereoselectivity.
The Glycosylation study combines topics in areas such as Trisaccharide, Reactivity and Nucleophile.
His Biochemistry research focuses on Enzyme, Activity-based proteomics, Active site, Glucocerebrosidase and Proteases.
His research in Proteases focuses on subjects like Cathepsin, which are connected to Cell biology.
His research in Proteasome intersects with topics in Cell culture, Cancer research, Protein subunit and Bortezomib.
He most often published in these fields:
- Stereochemistry (36.75%)
- Biochemistry (29.97%)
- Organic chemistry (13.58%)
What were the highlights of his more recent work (between 2016-2021)?
- Biochemistry (29.97%)
- Stereochemistry (36.75%)
- Enzyme (11.92%)
In recent papers he was focusing on the following fields of study:
Herman S. Overkleeft spends much of his time researching Biochemistry, Stereochemistry, Enzyme, Glycosylation and Cell biology.
Activity-based proteomics, Glucocerebrosidase, Recombinant DNA, Proteomics and Proteasome are among the areas of Biochemistry where the researcher is concentrating his efforts.
Herman S. Overkleeft has researched Proteasome in several fields, including Cancer research, Protein subunit and Pharmacology.
His Stereochemistry study combines topics from a wide range of disciplines, such as Stereoselectivity, Nucleophile, Oxocarbenium, Covalent bond and Glycoside hydrolase.
His Enzyme research integrates issues from Glycolipid, Glycoconjugate and Aziridine.
In his work, Tetrazine and Reagent is strongly intertwined with Combinatorial chemistry, which is a subfield of Glycosylation.
Between 2016 and 2021, his most popular works were:
- Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474 (155 citations)
- Carfilzomib resistance due to ABCB1/MDR1 overexpression is overcome by nelfinavir and lopinavir in multiple myeloma (49 citations)
- The influence of acceptor nucleophilicity on the glycosylation reaction mechanism (49 citations)
In his most recent research, the most cited papers focused on:
- Enzyme
- Gene
- Organic chemistry
Herman S. Overkleeft mainly investigates Biochemistry, Stereochemistry, Enzyme, Glycosylation and Glucocerebrosidase.
His primary area of study in Stereochemistry is in the field of Moiety.
His studies deal with areas such as Glycolipid, Beta and Heparanase as well as Enzyme.
His Glycosylation research is multidisciplinary, incorporating elements of Combinatorial chemistry, Reaction mechanism, Nucleophile and Stereoselectivity.
His study in Glucocerebrosidase is interdisciplinary in nature, drawing from both Lysosome, Disease monitoring, Chemical biology, Cyclophellitol and Zebrafish.
Herman S. Overkleeft interconnects Cell and Proteasome in the investigation of issues within MHC class I.
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