2023 - Research.com Biology and Biochemistry in Netherlands Leader Award
2023 - Research.com Chemistry in Netherlands Leader Award
Herman S. Overkleeft mainly focuses on Biochemistry, Proteasome, Stereochemistry, Organic chemistry and Glycosylation. His studies link Cell culture with Biochemistry. He combines subjects such as Cancer research, Ubiquitin, Protein degradation, Protein subunit and Bortezomib with his study of Proteasome.
Cycloaddition is closely connected to Chemical synthesis in his research, which is encompassed under the umbrella topic of Stereochemistry. His study looks at the intersection of Organic chemistry and topics like Combinatorial chemistry with Solid-phase synthesis and Proteomics. Herman S. Overkleeft works mostly in the field of Glycosylation, limiting it down to concerns involving Uronic acid and, occasionally, Oligosaccharide.
Herman S. Overkleeft mostly deals with Stereochemistry, Biochemistry, Organic chemistry, Proteasome and Combinatorial chemistry. His Stereochemistry research includes themes of Amino acid, Glycosylation, Chemical synthesis, Peptide and Stereoselectivity. The Glycosylation study combines topics in areas such as Trisaccharide, Reactivity and Nucleophile.
His Biochemistry research focuses on Enzyme, Activity-based proteomics, Active site, Glucocerebrosidase and Proteases. His research in Proteases focuses on subjects like Cathepsin, which are connected to Cell biology. His research in Proteasome intersects with topics in Cell culture, Cancer research, Protein subunit and Bortezomib.
Herman S. Overkleeft spends much of his time researching Biochemistry, Stereochemistry, Enzyme, Glycosylation and Cell biology. Activity-based proteomics, Glucocerebrosidase, Recombinant DNA, Proteomics and Proteasome are among the areas of Biochemistry where the researcher is concentrating his efforts. Herman S. Overkleeft has researched Proteasome in several fields, including Cancer research, Protein subunit and Pharmacology.
His Stereochemistry study combines topics from a wide range of disciplines, such as Stereoselectivity, Nucleophile, Oxocarbenium, Covalent bond and Glycoside hydrolase. His Enzyme research integrates issues from Glycolipid, Glycoconjugate and Aziridine. In his work, Tetrazine and Reagent is strongly intertwined with Combinatorial chemistry, which is a subfield of Glycosylation.
Herman S. Overkleeft mainly investigates Biochemistry, Stereochemistry, Enzyme, Glycosylation and Glucocerebrosidase. His primary area of study in Stereochemistry is in the field of Moiety. His studies deal with areas such as Glycolipid, Beta and Heparanase as well as Enzyme.
His Glycosylation research is multidisciplinary, incorporating elements of Combinatorial chemistry, Reaction mechanism, Nucleophile and Stereoselectivity. His study in Glucocerebrosidase is interdisciplinary in nature, drawing from both Lysosome, Disease monitoring, Chemical biology, Cyclophellitol and Zebrafish. Herman S. Overkleeft interconnects Cell and Proteasome in the investigation of issues within MHC class I.
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Proteasome Inhibitors: An Expanding Army Attacking a Unique Target
Alexei F. Kisselev;Wouter A. van der Linden;Herman S. Overkleeft.
Chemistry & Biology (2012)
A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14.
Anna Borodovsky;Benedikt M. Kessler;Rocco Casagrande;Herman S. Overkleeft.
The EMBO Journal (2001)
Thioglycosides in sequential glycosylation strategies
Jeroen D. C. Codée;Remy E. J. N. Litjens;Leendert J. van den Bos;Herman S. Overkleeft.
Chemical Society Reviews (2005)
Glycosphingolipids—Nature, Function, and Pharmacological Modulation
Tom Wennekes;Richard J. B. H. N. van den Berg;Rolf G. Boot;Gijsbert A. van der Marel.
Angewandte Chemie (2009)
Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474
Annelot C. M. van Esbroeck;Antonius P. A. Janssen;Armand B. Cognetta;Daisuke Ogasawara.
Analysis of Protease Activity in Live Antigen-presenting Cells Shows Regulation of the Phagosomal Proteolytic Contents During Dendritic Cell Activation
Ana Maria Lennon-Duménil;Arnold H. Bakker;René Maehr;Edda Fiebiger.
Journal of Experimental Medicine (2002)
Ph2SO/Tf2O: a powerful promotor system in chemoselective glycosylations using thioglycosides.
Jeroen D C Codée;Remy E J N Litjens;René den Heeten;Herman S Overkleeft.
Organic Letters (2003)
Elevated plasma glucosylsphingosine in Gaucher disease: relation to phenotype, storage cell markers, and therapeutic response
Nick Dekker;Laura van Dussen;Carla E. M. Hollak;Herman Overkleeft.
Generation of Specific Deoxynojirimycin-type Inhibitors of the Non-lysosomal Glucosylceramidase
Herman S. Overkleeft;G. Herma Renkema;Jolanda Neele;Paula Vianello.
Journal of Biological Chemistry (1998)
Ultrasensitive in situ visualization of active glucocerebrosidase molecules
Martin D Witte;Wouter W Kallemeijn;Jan Aten;Kah-Yee Li.
Nature Chemical Biology (2010)
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