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Herman S. Overkleeft

Herman S. Overkleeft

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Chemistry
Netherlands
2025

D-Index & Metrics

Chemistry

D-Index
85
Citations
27255
World Ranking
2655
National Ranking
64

Biology and Biochemistry

D-Index
86
Citations
27503
World Ranking
2951
National Ranking
76

Research.com Recognitions

  • 2025 - Research.com Chemistry in Netherlands Leader Award
  • 2022 - Research.com Chemistry in Netherlands Leader Award

Overview

Herman S. Overkleeft is affiliated with Leiden University in the Netherlands and has an extensive body of work primarily situated in the fields of Biochemistry, Genetics and Molecular Biology as well as Medicine. Their research focuses on molecular biology and organic chemistry, with additional contributions to physiology, biotechnology, and oncology.

The scientist's main research topics include:

  • Carbohydrate Chemistry and Synthesis
  • Glycosylation and Glycoproteins Research
  • Enzyme Production and Characterization
  • Lysosomal Storage Disorders Research
  • Calcium signaling and nucleotide metabolism
  • Chemical Synthesis and Analysis
  • Click Chemistry and Applications

Overkleeft has published numerous papers in frequent venues such as:

  • Journal of the American Chemical Society
  • ChemBioChem
  • Angewandte Chemie International Edition
  • Chemistry - A European Journal
  • Angewandte Chemie

Recent publications illustrate the range and focus of their research:

  • Uncoupling DNA damage from chromatin damage to detoxify doxorubicin, 2020, Proceedings of the National Academy of Sciences
  • Plant Glycosides and Glycosidases: A Treasure-Trove for Therapeutics, 2020, Frontiers in Plant Science
  • Characterization of glycosyl dioxolenium ions and their role in glycosylation reactions, 2020, Nature Communications
  • Fabry Disease: Molecular Basis, Pathophysiology, Diagnostics and Potential Therapeutic Directions, 2021, Biomolecules
  • The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Mediated Immune Responses, 2020, Immunity

Collaborative efforts form a significant part of Overkleeft's research output. Frequent co-authors include:

  • Jeroen D. C. Codée
  • G.J. Davies
  • Gijsbert A. van der Marel
  • Johannes M. F. G. Aerts
  • Dmitri V. Filippov

Best Publications

  • Proteasome Inhibitors: An Expanding Army Attacking a Unique Target

    Alexei F. Kisselev;Wouter A. van der Linden;Herman S. Overkleeft

  • A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14.

    Anna Borodovsky;Benedikt M. Kessler;Rocco Casagrande;Herman S. Overkleeft

  • Thioglycosides in sequential glycosylation strategies

    Jeroen D. C. Codée;Remy E. J. N. Litjens;Leendert J. van den Bos;Herman S. Overkleeft

  • Glycosphingolipids—Nature, Function, and Pharmacological Modulation

    Tom Wennekes;Richard J. B. H. N. van den Berg;Rolf G. Boot;Gijsbert A. van der Marel

  • Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474

    Annelot C. M. van Esbroeck;Antonius P. A. Janssen;Armand B. Cognetta;Daisuke Ogasawara

  • Elevated plasma glucosylsphingosine in Gaucher disease: relation to phenotype, storage cell markers, and therapeutic response

    Nick Dekker;Laura van Dussen;Carla E. M. Hollak;Herman Overkleeft

  • Ultrasensitive in situ visualization of active glucocerebrosidase molecules

    Martin D Witte;Wouter W Kallemeijn;Jan Aten;Kah-Yee Li

  • Ph2SO/Tf2O: a powerful promotor system in chemoselective glycosylations using thioglycosides.

    Jeroen D C Codée;Remy E J N Litjens;René den Heeten;Herman S Overkleeft

  • Analysis of Protease Activity in Live Antigen-presenting Cells Shows Regulation of the Phagosomal Proteolytic Contents During Dendritic Cell Activation

    Ana Maria Lennon-Duménil;Arnold H. Bakker;René Maehr;Edda Fiebiger

  • Generation of Specific Deoxynojirimycin-type Inhibitors of the Non-lysosomal Glucosylceramidase

    Herman S. Overkleeft;G. Herma Renkema;Jolanda Neele;Paula Vianello

  • Muscle Wasting in Aged, Sarcopenic Rats Is Associated with Enhanced Activity of the Ubiquitin Proteasome Pathway

    Mikael Altun;Mikael Altun;Henrike C. Besche;Herman S. Overkleeft;Rosanna Piccirillo

  • The Caspase-like Sites of Proteasomes, Their Substrate Specificity, New Inhibitors and Substrates, and Allosteric Interactions with the Trypsin-like Sites *

    Alexei F. Kisselev;Margarita Garcia-Calvo;Herman S. Overkleeft;Erin Peterson

  • Asymmetric Proteasome Segregation as a Mechanism for Unequal Partitioning of the Transcription Factor T-bet during T Lymphocyte Division

    John T. Chang;Maria L. Ciocca;Ichiko Kinjyo;Vikram R. Palanivel

  • A Fluorescent Broad-Spectrum Proteasome Inhibitor for Labeling Proteasomes In Vitro and In Vivo

    Martijn Verdoes;Bogdan I. Florea;Victoria Menendez-Benito;Christa J. Maynard

  • Chemistry in Living Cells: Detection of Active Proteasomes by a Two‐Step Labeling Strategy

    Huib Ovaa;Paul F. van Swieten;Benedikt M. Kessler;Michiel A. Leeuwenburgh

  • Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic β-subunits

    Benedikt M Kessler;Domenico Tortorella;Mikael Altun;Alexei F Kisselev

  • Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition

    Daisuke Ogasawara;Hui Deng;Andreu Viader;Marc P. Baggelaar

  • Selective inhibitor of proteasome's caspase-like sites sensitizes cells to specific inhibition of chymotrypsin-like sites.

    Matthew Britton;Marcella M. Lucas;Marcella M. Lucas;Sondra L. Downey;Michael Screen;Michael Screen

  • A modular strategy toward the synthesis of heparin-like oligosaccharides using monomeric building blocks in a sequential glycosylation strategy.

    Jeroen D. C. Codée;Bas Stubba;Marialuisa Schiattarella;Herman S. Overkleeft

  • Characterization of the ubiquitin-proteasome system in bortezomib-adapted cells.

    T Rückrich;M Kraus;J Gogel;A Beck

  • Thioglycuronides: synthesis and application in the assembly of acidic oligosaccharides.

    Leendert J van den Bos;Jeroen D C Codée;John C van der Toorn;Thomas J Boltje

Frequent Co-Authors

Jeroen D. C. Codée
Jeroen D. C. Codée Leiden University
Johannes M. F. G. Aerts
Johannes M. F. G. Aerts Leiden University
Christoph Driessen
Christoph Driessen University of St. Gallen
Rolf G. Boot
Rolf G. Boot Leiden University
Gideon J. Davies
Gideon J. Davies University of York
Huib Ovaa
Huib Ovaa Leiden University Medical Center
Ferry Ossendorp
Ferry Ossendorp Leiden University Medical Center
Benedikt M. Kessler
Benedikt M. Kessler University of Oxford
G. A. Van Der Marel
G. A. Van Der Marel Leiden University
Hidde L. Ploegh
Hidde L. Ploegh Boston Children's Hospital

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