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Chemistry

D-Index
51
Citations
9523
World Ranking
13929
National Ranking
3610

Overview

Paul H. Axelsen is affiliated with the University of Pennsylvania in the United States and has contributed extensively in the fields of biochemistry, genetics, molecular biology, and medicine. Their work encompasses multiple subfields including molecular biology, physiology, nutrition and dietetics, biochemistry, and infectious diseases.

The main research topics addressed by Axelsen include:

  • Alzheimer's disease research and treatments
  • Lipid membrane structure and behavior
  • Fatty acid research and health
  • Peroxisome proliferator-activated receptors
  • Algal biology and biofuel production
  • Antioxidant activity and oxidative stress
  • Retinal diseases and treatments

Selected recent publications highlight the range of Axelsen's research scope:

  • "Free Radical Chain Reactions and Polyunsaturated Fatty Acids in Brain Lipids," 2022, published in ACS Omega
  • "Deuterated docosahexaenoic acid protects against oxidative stress and geographic atrophy-like retinal degeneration in a mouse model with iron overload," 2022, Aging Cell
  • "The Potential for SARS-CoV-2 to Evade Both Natural and Vaccine-induced Immunity," 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • "Nanocarriers' repartitioning of drugs between blood subcompartments as a mechanism of improving pharmacokinetics, safety, and efficacy," 2024, Journal of Controlled Release
  • "A new synthetic medium for the optimization of docosahexaenoic acid production in Crypthecodinium cohnii," 2020, PLoS ONE

Axelsen has frequently published in venues such as Vaccine, Journal of Alzheimer's Disease, Biophysical Journal, UNC Libraries, and ACS Omega, with multiple papers appearing in the first three journals.

Among frequent collaborators, Axelsen has coauthored works with Hiroaki Komatsu, Sharon C.W. Ng, Ran Furman, Mikhail S. Shchepinov, and Pingping Song.

Best Publications

  • Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase.

    M Harel;I Schalk;L Ehret-Sabatier;F Bouet

  • The E46K Mutation in α-Synuclein Increases Amyloid Fibril Formation

    Eric A. Greenbaum;Charles L. Graves;Amanda J. Mishizen-Eberz;Michael A. Lupoli

  • Role of α-Synuclein Carboxy-Terminus on Fibril Formation in Vitro†

    Ian V. J. Murray;Benoit I. Giasson;Shawn M. Quinn;Vishwanath Koppaka

  • Open "Back Door" in a Molecular Dynamics Simulation of Acetylcholinesterase

    M. K. Gilson;T. P. Straatsma;J. A. McCammon;D. R. Ripoll

  • An electrostatic mechanism for substrate guidance down the aromatic gorge of acetylcholinesterase.

    Daniel R. Ripoll;Carlos H. Faerman;Paul H. Axelsen;Israel Silman

  • Copper and oxidative stress in the pathogenesis of Alzheimer's disease.

    Gözde Eskici;Paul H. Axelsen

  • Mass Spectrometric Analysis of Long-Chain Lipids

    Robert C. Murphy;Paul H. Axelsen

  • Structure and dynamics of the active site gorge of acetylcholinesterase: synergistic use of molecular dynamics simulation and X-ray crystallography.

    Paul H. Axelsen;Michal Harel;Israel Silman;Joel L. Sussman

  • Folding of beta-sheet membrane proteins: a hydrophobic hexapeptide model.

    William C. Wimley;Kalina Hristova;Alexey S. Ladokhin;Loraine Silvestro

  • Oxidative Stress and Cell Membranes in the Pathogenesis of Alzheimer's Disease

    Paul H. Axelsen;Hiroaki Komatsu;Ian V. J. Murray

  • The Structure of Human Lipoprotein A-I: EVIDENCE FOR THE “BELT” MODEL

    Vishwanath Koppaka;Loraine Silvestro;Jeffrey A. Engler;Christie G. Brouillette

  • Simultaneous Recognition of a Carboxylate-Containing Ligand and an Intramolecular Surrogate Ligand in the Crystal Structure of an Asymmetric Vancomycin Dimer

    Patrick J. Loll;Anthony E. Bevivino;Brian D. Korty;Paul H. Axelsen

  • 2D IR provides evidence for mobile water molecules in β-amyloid fibrils

    Yung Sam Kim;Liu Liu;Paul H. Axelsen;Robin M. Hochstrasser

  • The concentration-dependent membrane activity of cecropin A

    Loraine Silvestro;Kushol Gupta;Jeffrey N. Weiser;Paul H. Axelsen

  • Antibacterial and Antimembrane Activities of Cecropin A in Escherichia coli

    Loraine Silvestro;Jeffrey N. Weiser;Paul H. Axelsen

  • Accelerated accumulation of amyloid beta proteins on oxidatively damaged lipid membranes.

    Vishwanath Koppaka;Paul H. Axelsen

  • Two-dimensional infrared spectra of isotopically diluted amyloid fibrils from Aβ40

    Yung Sam Kim;Liu Liu;Paul H. Axelsen;Robin M. Hochstrasser

  • The structural biology of molecular recognition by vancomycin.

    Patrick J. Loll;Paul H. Axelsen

  • Buried water in homologous serine proteases.

    Uma Sreenivasan;Paul H. Axelsen

  • Vibrational Coupling, Isotopic Editing, and β-Sheet Structure in a Membrane-Bound Polypeptide

    Cynthia Paul;Jianping Wang;William C. Wimley;Robin M. Hochstrasser

Frequent Co-Authors

Robin M. Hochstrasser
Robin M. Hochstrasser University of Pennsylvania
Joel L. Sussman
Joel L. Sussman Weizmann Institute of Science
Jeffrey D. Winkler
Jeffrey D. Winkler University of Pennsylvania
Israel Silman
Israel Silman Weizmann Institute of Science
Michal Harel
Michal Harel Weizmann Institute of Science
Jeffrey N. Weiser
Jeffrey N. Weiser New York University
William C. Wimley
William C. Wimley Tulane University
Robert C. Murphy
Robert C. Murphy University of Colorado Denver
Mark P. Mattson
Mark P. Mattson Johns Hopkins University
Shaul Mukamel
Shaul Mukamel University of California, Irvine

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