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Medicine

D-Index
107
Citations
41399
World Ranking
6267
National Ranking
3342

Overview

Douglas W. Losordo is affiliated with Northwestern University in the United States. Their research primarily focuses on several interconnected topics within biomedical sciences and clinical applications.

Their recent publications cover a variety of subjects related to stem cell therapies and cardiovascular conditions. Notable papers include:

  • "CD34+ cell therapy significantly reduces adverse cardiac events, health care expenditures, and mortality in patients with refractory angina" (2020) published in Stem Cells Translational Medicine
  • "Design of a confirmatory pivotal study with intramyocardial GCSF-mobilized autologous CD34 cells (CLBS14) for the treatment of an orphan-sized population with no-option refractory disabling angina" (2020) published in Cytotherapy
  • "Design of a potentially registrational study of sakigake-designated GCSF-Mobilized autologous CD34 cell (CLBS12) Therapy of no-option critical limb ischemia including arteriosclerosis obliterans and Buerger's Disease" (2020) published in Cytotherapy
  • "Editorial Board" (2020) published in Cytotherapy
  • "Issue Information" (2020) published in Stem Cells Translational Medicine

Losordo frequently collaborates with several other researchers, among whom the most common co-authors are:

  • Charles S. Cox
  • Jaap Jan Boelens
  • Rachele Ciccocioppo
  • Nancy Collins
  • Colleen Delaney

The principal venues where Losordo's work appears include:

  • Cytotherapy
  • Stem Cells Translational Medicine
  • Cell and Gene Therapy Insights
  • Circulation
  • UNC Libraries

Their research spans numerous fields and subfields of biomedical science, such as:

  • Surgery
  • Molecular Biology
  • Genetics
  • Economics and Econometrics
  • Anesthesiology and Pain Medicine

Key research topics addressed in Losordo's work include:

  • Mesenchymal stem cell research
  • Health systems, economic evaluations, quality of life
  • Peripheral artery disease management
  • Angiogenesis and VEGF in cancer
  • Pain management and treatment
  • Cardiac and coronary surgery techniques
  • Nuclear receptors and signaling

Overall, the scope of Losordo's scientific contributions integrates clinical research on stem cell therapies with interdisciplinary investigations into vascular diseases, pain management, and health economics.

Best Publications

  • Stromal Cell–Derived Factor-1 Effects on Ex Vivo Expanded Endothelial Progenitor Cell Recruitment for Ischemic Neovascularization

    Jun-ichi Yamaguchi;Kengo Fukushima Kusano;Osamu Masuo;Atsuhiko Kawamoto

  • Statin Therapy Accelerates Reendothelialization A Novel Effect Involving Mobilization and Incorporation of Bone Marrow-Derived Endothelial Progenitor Cells

    Dirk H. Walter;Kilian Rittig;Ferdinand H. Bahlmann;Rudolf Kirchmair

  • Gene Therapy for Myocardial Angiogenesis : Initial Clinical Results With Direct Myocardial Injection of phVEGF165 as Sole Therapy for Myocardial Ischemia

    Douglas W. Losordo;Peter R. Vale;James F. Symes;Cheryl H. Dunnington

  • Intramyocardial Transplantation of Autologous Endothelial Progenitor Cells for Therapeutic Neovascularization of Myocardial Ischemia

    Atsuhiko Kawamoto;Tengis Tkebuchava;Jun Ichi Yamaguchi;Hiromi Nishimura

  • Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages

    Kazuichi Maruyama;Masaaki Ii;Claus Cursiefen;Claus Cursiefen;David G. Jackson

  • Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction

    Young Sup Yoon;Andrea Wecker;Lindsay Heyd;Jong Seon Park

  • Critical Reevaluation of Endothelial Progenitor Cell Phenotypes for Therapeutic and Diagnostic Use

    Gian Paolo Fadini;Douglas Losordo;Stefanie Dimmeler

  • Variable expression of the estrogen receptor in normal and atherosclerotic coronary arteries of premenopausal women

    D W Losordo;M Kearney;E A Kim;J Jekanowski

  • Phase 1/2 Placebo-Controlled, Double-Blind, Dose-Escalating Trial of Myocardial Vascular Endothelial Growth Factor 2 Gene Transfer by Catheter Delivery in Patients With Chronic Myocardial Ischemia

    Douglas W. Losordo;Peter R. Vale;Robert C. Hendel;Charles E. Milliken

  • Exosomes From Human CD34+ Stem Cells Mediate Their Proangiogenic Paracrine Activity

    Susmita Sahoo;Ekaterina Klychko;Tina Thorne;Sol Misener

  • Intramyocardial transplantation of autologous CD34+ stem cells for intractable angina: a phase I/IIa double-blind, randomized controlled trial.

    Douglas W. Losordo;Richard A. Schatz;Christopher J. White;James E. Udelson

  • Estrogen-Mediated, Endothelial Nitric Oxide Synthase–Dependent Mobilization of Bone Marrow–Derived Endothelial Progenitor Cells Contributes to Reendothelialization After Arterial Injury

    Atsushi Iwakura;Corinne Luedemann;Shubha Shastry;Allison Hanley

  • Exosomes and Cardiac Repair After Myocardial Infarction

    Susmita Sahoo;Douglas W. Losordo

  • Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing.

    Kazuichi Maruyama;Kazuichi Maruyama;Jun Asai;Jun Asai;Masaaki;Tina Thorne

  • Intramyocardial, Autologous CD34+ Cell Therapy for Refractory Angina

    Douglas W. Losordo;Timothy D. Henry;Charles Davidson;Joon Sup Lee

  • Determination of bone marrow-derived endothelial progenitor cell significance in angiogenic growth factor-induced neovascularization in vivo.

    Toshinori Murayama;Oren M Tepper;Oren M Tepper;Marcy Silver;Hong Ma

  • Therapeutic Angiogenesis and Vasculogenesis for Ischemic Disease Part II: Cell-Based Therapies

    Douglas W. Losordo;Stefanie Dimmeler

  • Acetylcysteine to prevent angiography-related renal tissue injury (the APART trial).

    Larry J Diaz-Sandoval;Bernard D Kosowsky;Douglas W Losordo

  • Gene therapy with vascular endothelial growth factor for inoperable coronary artery disease.

    James F Symes;Douglas W Losordo;Peter R Vale;Kishor G Lathi

  • Randomized, single-blind, placebo-controlled pilot study of catheter-based myocardial gene transfer for therapeutic angiogenesis using left ventricular electromechanical mapping in patients with chronic myocardial ischemia.

    Peter R. Vale;Douglas W. Losordo;Charles E. Milliken;Maria C. McDonald

Frequent Co-Authors

Jeffrey M. Isner
Jeffrey M. Isner Tufts University
Takayuki Asahara
Takayuki Asahara Tokai University
Timothy D. Henry
Timothy D. Henry Cedars-Sinai Medical Center
Stefanie Dimmeler
Stefanie Dimmeler Goethe University Frankfurt
Douglas E. Vaughan
Douglas E. Vaughan Northwestern University
Samuel I. Stupp
Samuel I. Stupp Northwestern University
Dean J. Kereiakes
Dean J. Kereiakes The Christ Hospital Health Network
Andreas M. Zeiher
Andreas M. Zeiher Goethe University Frankfurt
Toyoaki Murohara
Toyoaki Murohara Nagoya University
Robert A. Harrington
Robert A. Harrington Cornell University

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