World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
55
Citations
9324
World Ranking
12296
National Ranking
3276

Overview

Jeffrey D. Winkler is affiliated with the University of Pennsylvania in the United States. Their research spans multiple disciplines, with a focus primarily on medicine and materials science. These fields encompass subfields such as materials chemistry, oncology, organic chemistry, molecular biology, and surgery.

Their scientific work has been published extensively in several venues. Notable frequent publication outlets include:

  • The Cambridge Structural Database
  • JCI Insight
  • The Journal of Organic Chemistry
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Bioorganic & Medicinal Chemistry Letters

Areas of research interest and main topics covered by Jeffrey D. Winkler include the study of crystallization and solubility, X-ray diffraction in crystallography, autophagy in disease and therapy, pediatric hepatobiliary diseases and treatments, CAR-T cell therapy research, neuroscience and neuropharmacology research, as well as asymmetric synthesis and catalysis.

Their recent notable publications feature a range of studies in cellular biology, cancer research, metabolism, and synthetic chemistry. These include:

  • SIRT1 is downregulated by autophagy in senescence and ageing (2020) published in Nature Cell Biology
  • PPT1 inhibition enhances the antitumor activity of anti-PD-1 antibody in melanoma (2020) published in JCI Insight
  • Lysosomal lipid peroxidation regulates tumor immunity (2023) published in Journal of Clinical Investigation
  • Targeting acetyl-CoA metabolism attenuates the formation of fear memories through reduced activity-dependent histone acetylation (2022) published in Proceedings of the National Academy of Sciences
  • Synthesis of Cyclohexane-Angularly-Fused Triquinanes (2020) published in Synthesis

Jeffrey D. Winkler has collaborated frequently with several researchers, among them:

  • Tyler F. Higgins
  • Ravi K. Amaravadi
  • Andrew G. Glass
  • Michael C. Nicastri
  • Benjamin A. García

Best Publications

  • Tandem Diels−Alder Cycloadditions in Organic Synthesis

    Jeffrey D. Winkler

  • SIRT1 is downregulated by autophagy in senescence and ageing.

    Caiyue Xu;Lu Wang;Parinaz Fozouni;Parinaz Fozouni;Gry Evjen

  • Reduction of Clofazimine by Mycobacterial Type 2 NADH:Quinone Oxidoreductase A PATHWAY FOR THE GENERATION OF BACTERICIDAL LEVELS OF REACTIVE OXYGEN SPECIES

    Takahiro Yano;Sacha Kassovska-Bratinova;J. Shin Teh;Jeffrey Winkler

  • De novo design and in vivo activity of conformationally restrained antimicrobial arylamide foldamers

    Sungwook Choi;Andre Isaacs;Dylan Clements;Dahui Liu

  • Nontoxic Membrane-Active Antimicrobial Arylamide Oligomers†

    Dahui Liu;Sungwook Choi;Bin Chen;Bin Chen;Robert J. Doerksen

  • Photodynamic Fluorescent Metal Ion Sensors with Parts per Billion Sensitivity

    Jeffrey D. Winkler;and Corinne M. Bowen;Veronique Michelet

  • 2 + 2 PHOTOCYCLOADDITION/FRAGMENTATION STRATEGIES FOR THE SYNTHESIS OF NATURAL AND UNNATURAL PRODUCTS

    Jeffrey D. Winkler;Corinne Mazur. Bowen;Fina. Liotta

  • PPT1 promotes tumor growth and is the molecular target of chloroquine derivatives in cancer.

    Vito W. Rebecca;Michael C. Nicastri;Colin Fennelly;Cynthia I. Chude

  • The first total synthesis of ingenol

    Jeffrey D. Winkler;Meagan B. Rouse;Michael F. Greaney;Sean J. Harrison

  • The First Total Syntheses of Ircinol A, Ircinal A, and Manzamines A and D.

    Jeffrey D. Winkler;Jeffrey M. Axten

  • Mimics of transaminase enzymes

    R. Breslow;A. W. Czarnik;M. Lauer;R. Leppkes

  • Development of Potent and Selective Inhibitors of Aldo–Keto Reductase 1C3 (Type 5 17β-Hydroxysteroid Dehydrogenase) Based on N-Phenyl-Aminobenzoates and Their Structure–Activity Relationships

    Adegoke O. Adeniji;Barry M. Twenter;Michael C. Byrns;Yi Jin

  • Sex steroids regulate skin pigmentation through nonclassical membrane-bound receptors

    Christopher A Natale;Elizabeth K Duperret;Junqian Zhang;Rochelle Sadeghi

  • Targeting quiescent leukemic stem cells using second generation autophagy inhibitors

    Pablo Baquero;Amy Dawson;Arunima Mukhopadhyay;Elodie M. Kuntz

  • A MODEL FOR THE TAXOL (PACLITAXEL)/EPOTHILONE PHARMACOPHORE

    Jeffrey D. Winkler;Paul H. Axelsen

  • Photodynamic transport of metal ions

    Jeffrey D. Winkler;Kurt Deshayes;Bin Shao

  • Asymmetric induction in the vinylogous amide photocycloaddition reaction. A formal synthesis of vindorosine

    Jeffrey D. Winkler;Robert D. Scott;Paul G. Williard

  • Photoinduced switching of metal complexation by quinolinospiropyranindolines in polar solvents

    Greg E. Collins;Ling-Siu Choi;Kenneth J. Ewing;Veronique Michelet

  • Enantioselective Synthesis of d-threo-Methylphenidate

    Jeffrey M. Axten;Robert Ivy;Lori Krim;Jeffrey D. Winkler

  • Autophagy Gene Atg16l1 Prevents Lethal T Cell Alloreactivity Mediated by Dendritic Cells

    Vanessa M. Hubbard-Lucey;Yusuke Shono;Katie Maurer;Mallory L. West

  • Identification of a novel family of BRAF(V600E) inhibitors.

    Jie Qin;Peng Xie;Christian Ventocilla;Guoqiang Zhou

Frequent Co-Authors

Ravi K. Amaravadi
Ravi K. Amaravadi University of Pennsylvania
Paul G. Williard
Paul G. Williard Brown University
Sanghee Kim
Sanghee Kim Seoul National University
William F. DeGrado
William F. DeGrado University of California, San Francisco
Ronen Marmorstein
Ronen Marmorstein University of Pennsylvania
Michael L. Klein
Michael L. Klein Temple University
Trevor M. Penning
Trevor M. Penning University of Pennsylvania
Ronald Breslow
Ronald Breslow Columbia University
Marcella Devoto
Marcella Devoto University of Pennsylvania
Mark T. Hamann
Mark T. Hamann Medical University of South Carolina

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Studying chemistry in the USA opens doors to diverse career pathways that often intersect with healthcare, legal, and pharmaceutical sectors. For students seeking flexible learning, related online degrees can provide essential knowledge and skills to enter these fields. For example, understanding the "paralegal salary" potential can guide chemistry graduates interested in legal roles that support intellectual property or patent law involving chemical inventions.

In the pharmaceutical industry, becoming a pharmaceutical sales representative offers a rewarding option. Exploring the "pharma sales rep salary" helps prospective candidates weigh the benefits of leveraging their chemistry background to communicate complex product information effectively to healthcare providers.

For those interested in clinical applications, pathways such as pharmacy provide a stable career, with the "pharmacist salary" reflecting the high demand and expertise required. Chemistry students can transition into this role through accredited pharmacy programs and licensure.

Another niche career is working as an autopsy technician. While this role requires specialized skills, "autopsy technician school" programs can provide the necessary training, enabling chemistry graduates to apply their knowledge of biochemistry and anatomy in forensic investigations.

Overall, these related fields demonstrate the versatility of a chemistry education and underscore the value of exploring various online degrees to enhance career prospects.

Best Scientists Citing Jeffrey D. Winkler

Trending Scientists

Recently Published Articles