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Microbiology
New Zealand
2025

D-Index & Metrics

Microbiology

D-Index
69
Citations
14760
World Ranking
2083
National Ranking
69

Research.com Recognitions

  • 2025 - Research.com Microbiology in New Zealand Leader Award
  • 2013 - Fellow of the Royal Society of New Zealand

Overview

Gregory M. Cook is affiliated with the University of Otago in New Zealand. Their research primarily focuses on biochemistry, genetics, and molecular biology, with significant contributions to medicine. Their work spans molecular biology, infectious diseases, epidemiology, molecular medicine, and organic chemistry, reflecting a broad engagement with multiple scientific subfields.

Cook's main research topics include tuberculosis research and epidemiology, Mycobacterium research and diagnosis, and antibiotic resistance in bacteria. Other areas of interest are cancer therapeutics and mechanisms, bacterial genetics and biotechnology, ATP synthase and ATPases research, and antimicrobial peptides and activities.

The scientist has published extensively, with frequent appearances in several scientific venues. These include bioRxiv (Cold Spring Harbor Laboratory) with 18 publications, Antimicrobial Agents and Chemotherapy with 6 publications, ACS Infectious Diseases with 6 publications, Nature Communications with 5 publications, and the Journal of Medicinal Chemistry with 5 publications.

Several coauthors have frequently collaborated with Cook, including Chen-Yi Cheung, Matthew B. McNeil, Kiel Hards, Scott Ferguson, and Margaret A. Brimble.

Notable recent papers authored include:

  • Dual inhibition of the terminal oxidases eradicates antibiotic-tolerant Mycobacterium tuberculosis, 2020, EMBO Molecular Medicine
  • Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineering, 2020, PLoS Pathogens
  • Structural basis for bacterial energy extraction from atmospheric hydrogen, 2023, Nature
  • The evolution of antibiotic resistance is associated with collateral drug phenotypes in Mycobacterium tuberculosis, 2023, Nature Communications
  • The cryo-EM structure of the bd oxidase from M. tuberculosis reveals a unique structural framework and enables rational drug design to combat TB, 2021, Nature Communications

Gregory M. Cook was recognized as a Fellow of the Royal Society of New Zealand in 2013.

Best Publications

  • Energetics of bacterial growth: balance of anabolic and catabolic reactions.

    J B Russell;G M Cook

  • Genomic and metagenomic surveys of hydrogenase distribution indicate H2 is a widely utilised energy source for microbial growth and survival.

    Chris Greening;Ambarish Biswas;Carlo R Carere;Colin J Jackson

  • Redundancy of aerobic respiratory chains in bacteria? Routes, reasons and regulation

    Robert K. Poole;Gregory M. Cook

  • Isolation and characterization of arsenate-reducing bacteria from arsenic-contaminated sites in New Zealand.

    Craig R. Anderson;Gregory M. Cook

  • Catabolite repression and inducer control in Gram-positive bacteria

    Milton H. Saier;Sylvie Chauvaux;Gregory M. Cook;Josef Deutscher

  • Diverse hydrogen production and consumption pathways influence methane production in ruminants.

    Chris Greening;Renae Geier;Cecilia Wang;Laura C. Woods

  • Unique flexibility in energy metabolism allows mycobacteria to combat starvation and hypoxia.

    Michael Berney;Gregory M. Cook

  • Physiology of mycobacteria.

    Gregory M. Cook;Michael Berney;Susanne Gebhard;Matthias Heinemann

  • Bactericidal mode of action of bedaquiline

    Kiel Hards;Jennifer R. Robson;Michael Berney;Lisa Shaw

  • Unique Rotary ATP Synthase and Its Biological Diversity

    Christoph von Ballmoos;Gregory M Cook;Peter Dimroth

  • The PIN-domain ribonucleases and the prokaryotic VapBC toxin–antitoxin array

    Vickery L. Arcus;Joanna Leigh McKenzie;Jennifer R. Robson;Gregory M. Cook

  • Energetics of Respiration and Oxidative Phosphorylation in Mycobacteria

    Gregory M. Cook;Kiel Hards;Catherine Vilchèze;Travis Hartman

  • Exploiting the synthetic lethality between terminal respiratory oxidases to kill Mycobacterium tuberculosis and clear host infection.

    Nitin Pal Kalia;Erik J. Hasenoehrl;Nurlilah Binte Ab Rahman;Vanessa H. Koh

  • Intracellular pH regulation by Mycobacterium smegmatis and Mycobacterium bovis BCG

    Min Rao;Trevor L. Streur;Frank E. Aldwell;Gregory M. Cook

  • A soil actinobacterium scavenges atmospheric H2 using two membrane-associated, oxygen-dependent [NiFe] hydrogenases

    Christopher Andrew Greening;Michael Berney;Michael Berney;Kiel Hards;Gregory M. Cook

  • An obligately aerobic soil bacterium activates fermentative hydrogen production to survive reductive stress during hypoxia

    Michael Berney;Chris Greening;Chris Greening;Ralf Conrad;William R. Jacobs

  • Fitness cost of staphylococcal cassette chromosome mec in methicillin-resistant Staphylococcus aureus by way of continuous culture

    Sui Mae Lee;Miriam Ender;Rajan Adhikari;Rajan Adhikari;John M. B. Smith

  • Structure of the bacterial type II NADH dehydrogenase: a monotopic membrane protein with an essential role in energy generation

    Adam Heikal;Yoshio Nakatani;Elyse Dunn;Marion R. Weimar

  • The F1Fo-ATP Synthase of Mycobacterium smegmatis Is Essential for Growth

    Sieu L. Tran;Gregory M. Cook

  • Persistence of the dominant soil phylum Acidobacteria by trace gas scavenging

    Christopher Andrew Greening;Christopher Andrew Greening;Carlo C. Carere;Rowena Rushton-Green;Liam K. Harold

  • The cytochrome bd-type quinol oxidase is important for survival of Mycobacterium smegmatis under peroxide and antibiotic-induced stress.

    Ping Lu;Marieke H. Heineke;Anil Koul;Koen Andries

  • The vapBC operon from Mycobacterium smegmatis is an autoregulated toxin-antitoxin module that controls growth via inhibition of translation.

    Jennifer Robson;Joanna L. McKenzie;Ray Cursons;Gregory M. Cook

Frequent Co-Authors

James B. Russell
James B. Russell Agricultural Research Service
Peter Dimroth
Peter Dimroth ETH Zurich
Colin J. Jackson
Colin J. Jackson Australian National University
Robert K. Poole
Robert K. Poole University of Sheffield
Edward N. Baker
Edward N. Baker University of Auckland
Sharon J. Peacock
Sharon J. Peacock University of Cambridge
Scott A. Beatson
Scott A. Beatson University of Queensland
Timothy P. Stinear
Timothy P. Stinear University of Melbourne
Hugh W. Morgan
Hugh W. Morgan University of Waikato
John E. Walker
John E. Walker University of Cambridge

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Related Online Degrees & Career Pathways

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Additionally, a career as a child life specialist offers a unique way to apply scientific knowledge in a therapeutic and supportive environment, helping children and families cope with medical challenges through psychological support and education.

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