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Biology and Biochemistry
UK
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
125
Citations
57947
World Ranking
509
National Ranking
29

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2025 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2023 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2004 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

John E. Walker is a researcher affiliated with the University of Cambridge in the United Kingdom. Their work primarily centers on the fields of biochemistry, genetics, and molecular biology, with a strong focus on molecular biology.

The research topics covered by Walker include mitochondrial function and pathology, ATP synthase and ATPases research, photosynthetic processes and mechanisms, metabolism and genetic disorders, amino acid enzymes and metabolism, biochemical and molecular research, and amoebic infections and treatments.

Walker has published extensively in several scientific venues. Frequent publication outlets include:

  • Proceedings of the National Academy of Sciences
  • Biochimica et Biophysica Acta (BBA) - Bioenergetics
  • American Journal of Psychiatry
  • Journal of Biological Chemistry
  • Molecular Metabolism

Their recent papers reflect a concentration on ATP synthase structure and function as well as mitochondrial bioenergetics. Notable recent publications are:

  • "Structure of the dimeric ATP synthase from bovine mitochondria," 2020, Proceedings of the National Academy of Sciences
  • "Interface mobility between monomers in dimeric bovine ATP synthase participates in the ultrastructure of inner mitochondrial membranes," 2021, Proceedings of the National Academy of Sciences
  • "TMEM70 and TMEM242 help to assemble the rotor ring of human ATP synthase and interact with assembly factors for complex I," 2021, Proceedings of the National Academy of Sciences
  • "Structure of the ATP synthase from Mycobacterium smegmatis provides targets for treating tuberculosis," 2021, Proceedings of the National Academy of Sciences
  • "Assembly of the peripheral stalk of ATP synthase in human mitochondria," 2020, Proceedings of the National Academy of Sciences

Collaborations form an important part of Walker's research output. Frequent co-authors include:

  • Jiuya He
  • M.G. Montgomery
  • Joe Carroll
  • Ian M. Fearnley
  • T.E. Spikes

Walker was recognized as a Fellow of the American Association for the Advancement of Science (AAAS) in 2004. This distinction marks an acknowledgment of contributions within their scientific disciplines.

Best Publications

  • Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.

    J.E. Walker;M. Saraste;M.J. Runswick

  • Structure at 2.8 A resolution of F1-ATPase from bovine heart mitochondria.

    Jan Pieter Abrahams;Andrew G. W. Leslie;René Lutter;René Lutter;John E. Walker

  • Over-production of proteins in Escherichia coli: mutant hosts that allow synthesis of some membrane proteins and globular proteins at high levels.

    Bruno Miroux;John E. Walker

  • Molecular architecture of the rotary motor in ATP synthase

    Daniela Stock;Andrew G. W. Leslie;John E. Walker

  • Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau

    M Goedert;C M Wischik;R A Crowther;J E Walker

  • Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease

    C M Wischik;M Novak;H C Thøgersen;P C Edwards

  • The NADH:ubiquinone oxidoreductase (complex I) of respiratory chains.

    John E. Walker

  • Ectopic beta-chain of ATP synthase is an apolipoprotein A-I receptor in hepatic HDL endocytosis.

    Laurent O. Martinez;Sébastien Jacquet;Jean-Pierre Esteve;Corinne Rolland

  • The UNC operon nucleotide sequence, regulation and structure of ATP-synthase

    John E. Walker;Matti Saraste

  • The ATP synthase: the understood, the uncertain and the unknown

    John E. Walker

  • Bioenergetic cost of making an adenosine triphosphate molecule in animal mitochondria

    Ian N. Watt;Martin G. Montgomery;Michael J. Runswick;Andrew G. W. Leslie

  • The Structure of the Central Stalk in Bovine F(1)-ATPase at 2.4 A Resolution.

    Clyde Gibbons;Martin G. Montgomery;Andrew G. W. Leslie;John E. Walker

  • Bovine complex I is a complex of 45 different subunits.

    Joe Carroll;Ian M. Fearnley;J. Mark Skehel;Richard J. Shannon

  • Structure of Bovine Mitochondrial F1-ATPase with Nucleotide Bound to All Three Catalytic Sites: Implications for the Mechanism of Rotary Catalysis

    R.Ian Menz;John E. Walker;John E. Walker;Andrew G.W. Leslie

  • Primary structure and subunit stoichiometry of F1-ATPase from bovine mitochondria

    J.E. Walker;I.M. Fearnley;B.W. Gibson

  • Citrin and aralar1 are Ca2+‐stimulated aspartate/glutamate transporters in mitochondria

    Luigi Palmieri;B. Pardo;F. M. Lasorsa;A. Del Arco;A. Del Arco

  • Mechanism of Inhibition of Bovine F1-ATPase by Resveratrol and Related Polyphenols.

    Jonathan R. Gledhill;Martin G. Montgomery;Andrew G. W. Leslie;John E. Walker

  • The nuclear encoded subunits of complex I from bovine heart mitochondria.

    Judy Hirst;Joe Carroll;Ian M. Fearnley;Richard J. Shannon

  • Analysis of the Subunit Composition of Complex I from Bovine Heart Mitochondria

    Joe Carroll;Ian M. Fearnley;Richard J. Shannon;Judy Hirst

  • Structure of the rotor of the V-Type Na^+-ATPase from Enterococcus hirae

    Takeshi Murata;Ichiro Yamato;Yoshimi Kakinuma;Andrew G. W. Leslie

Frequent Co-Authors

Michael J. Runswick
Michael J. Runswick Medical Research Council
Ian M. Fearnley
Ian M. Fearnley University of Cambridge
Andrew G. W. Leslie
Andrew G. W. Leslie MRC Laboratory of Molecular Biology
Ferdinando Palmieri
Ferdinando Palmieri University of Bari Aldo Moro
Matti Saraste
Matti Saraste European Bioinformatics Institute
Luigi Palmieri
Luigi Palmieri University of Bari Aldo Moro
Jan Pieter Abrahams
Jan Pieter Abrahams Paul Scherrer Institute
J. Mark Skehel
J. Mark Skehel MRC Laboratory of Molecular Biology
John L. Rubinstein
John L. Rubinstein University of Toronto
Judy Hirst
Judy Hirst University of Cambridge

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