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Jan Pieter Abrahams

Jan Pieter Abrahams

D-Index & Metrics

Chemistry

D-Index
49
Citations
13490
World Ranking
14642
National Ranking
256

Overview

Jan Pieter Abrahams is affiliated with the Paul Scherrer Institute in Switzerland. Their research spans multiple fields including Biochemistry, Genetics and Molecular Biology, and Materials Science, with a strong focus on subfields such as Molecular Biology, Materials Chemistry, Structural Biology, Surfaces, Coatings and Films, and Radiation.

Their work covers a range of main scientific topics, including:

  • Enzyme Structure and Function
  • Advanced Electron Microscopy Techniques and Applications
  • Electron and X-Ray Spectroscopy Techniques
  • Genomics and Phylogenetic Studies
  • Supramolecular Self-Assembly in Materials
  • Protein Structure and Dynamics
  • ATP Synthase and ATPases Research

Jan Pieter Abrahams has authored multiple research papers, with recent significant publications including:

  • "Cryo-electron Microscopy Imaging of Alzheimer's Amyloid-beta 42 Oligomer Displayed on a Functionally and Structurally Relevant Scaffold", 2021, Angewandte Chemie International Edition
  • "Shape-Shifting Peptide Nanomaterials: Surface Asymmetry Enables pH-Dependent Formation and Interconversion of Collagen Tubes and Sheets", 2020, Journal of the American Chemical Society
  • "A lipocalin mediates unidirectional heme biomineralization in malaria parasites", 2020, Proceedings of the National Academy of Sciences
  • "Sub-pixel electron detection using a convolutional neural network", 2020, Ultramicroscopy
  • "Catalytic cycling of human mitochondrial Lon protease", 2022, Structure

Their frequent collaborators include Eric van Genderen, Thorsten B. Blum, Senik Matinyan, Pavel Filipčík, and E. Fröjdh.

Publications by Jan Pieter Abrahams have appeared in various venues, notably:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Acta Crystallographica Section A Foundations and Advances
  • Ultramicroscopy
  • Zenodo (CERN European Organization for Nuclear Research)
  • Angewandte Chemie International Edition

Best Publications

  • Structure at 2.8 A resolution of F1-ATPase from bovine heart mitochondria.

    Jan Pieter Abrahams;Andrew G. W. Leslie;René Lutter;René Lutter;John E. Walker

  • Methods used in the structure determination of bovine mitochondrial F1 ATPase.

    J. P. Abrahams;A. G. W. Leslie

  • The anticoagulant activation of antithrombin by heparin.

    Lei Jin;Jan Pieter Abrahams;Jan Pieter Abrahams;Richard Skinner;Maurice Petitou

  • 3D Electron Diffraction: The Nanocrystallography Revolution.

    Mauro Gemmi;Enrico Mugnaioli;Tatiana E. Gorelik;Ute Kolb;Ute Kolb

  • Inhibitory conformation of the reactive loop of alpha 1-antitrypsin.

    Peter R. Elliott;David A. Lomas;Robin W. Carrell;Jan Pieter Abrahams

  • The crystal structure of the nucleotide-free α3β3 subcomplex of F1-ATPase from the thermophilic Bacillus PS3 is a symmetric trimer

    Yasuo Shirakihara;Andrew G. W. Leslie;Jan Pieter Abrahams;John E. Walker

  • The 2.6 Å structure of antithrombin indicates a conformational change at the heparin binding site

    Richard Skinner;Jan Pieter Abrahams;James C. Whisstock;Arthur M. Lesk

  • Importance of nuclear localization of apoptin for tumor-specific induction of apoptosis.

    Astrid A.A.M. Danen-van Oorschot;Ying-Hui Zhang;S.Rutger Leliveld;Jennifer L. Rohn

  • The Structure of Bovine F1-ATPase Complexed with the Peptide Antibiotic Efrapeptin.

    J. P. Abrahams;S. K. Buchanan;M. J. Van Raaij;I. M. Fearnley

  • The structure of bovine F1-ATPase complexed with the antibiotic inhibitor aurovertin B.

    M. J. Van Raaij;J. P. Abrahams;A. G. W. Leslie;J. E. Walker

  • A Medipix quantum area detector allows rotation electron diffraction data collection from submicrometre three-dimensional protein crystals

    Igor Nederlof;Eric van Genderen;Yao Wang Li;Jan Pieter Abrahams

  • Ab initio structure determination of nanocrystals of organic pharmaceutical compounds by electron diffraction at room temperature using a Timepix quantum area direct electron detector

    E. van Genderen;E. van Genderen;M. T. B. Clabbers;M. T. B. Clabbers;P. P. Das;A. Stewart

  • Structure of β-Antithrombin and the Effect of Glycosylation on Antithrombin's Heparin Affinity and Activity

    Airlie J McCoy;Xue Yuan Pei;Richard Skinner;Jan Pieter Abrahams

  • Wild-type alpha 1-antitrypsin is in the canonical inhibitory conformation.

    Peter R Elliott;Jan-Pieter Abrahams;David A Lomas

  • CRANK: new methods for automated macromolecular crystal structure solution.

    Steven R. Ness;Rudolf A.G. de Graaff;Jan Pieter Abrahams;Navraj S. Pannu

  • Cross-interactions between the Alzheimer Disease Amyloid-β Peptide and Other Amyloid Proteins: A Further Aspect of the Amyloid Cascade Hypothesis

    Jinghui Luo;Sebastian K.T.S. Wärmländer;Astrid Gräslund;Jan Pieter Abrahams;Jan Pieter Abrahams

  • Implications for function and therapy of a 2.9 A structure of binary-complexed antithrombin.

    Richard Skinner;Wun-Shaing W Chang;Lei Jin;Xue Pei

  • The Structure of the Receptor-binding Domain of the Bacteriophage T4 Short Tail Fibre Reveals a Knitted Trimeric Metal-binding Fold

    Ellen Thomassen;Gerrit Gielen;Michael Schütz;Guy Schoehn

  • ATP-induced conformational changes of the nucleotide-binding domain of Na,K-ATPase

    Mark Hilge;Mark Hilge;Gregg Siegal;Geerten W Vuister;Peter Güntert

  • Electron diffraction data processing with DIALS

    Max T. B. Clabbers;Tim Gruene;James M. Parkhurst;Jan Pieter Abrahams;Jan Pieter Abrahams

  • Apoptin Induces Tumor-specific Apoptosis as a Globular Multimer

    Sirik R. Leliveld;Ying-Hui Zhang;Jennifer L. Rohn;Mathieu H.M. Noteborn

  • The hairpin conformation of the amyloid β peptide is an important structural motif along the aggregation pathway

    Axel Abelein;Jan Pieter Abrahams;Jens Danielsson;Astrid Gräslund

Frequent Co-Authors

Andrew G. W. Leslie
Andrew G. W. Leslie MRC Laboratory of Molecular Biology
Astrid Gräslund
Astrid Gräslund Stockholm University
Robin W. Carrell
Robin W. Carrell University of Cambridge
John E. Walker
John E. Walker University of Cambridge
Zunfeng Liu
Zunfeng Liu Nankai University
Henny W. Zandbergen
Henny W. Zandbergen Delft University of Technology
Cornelis H. Hokke
Cornelis H. Hokke Leiden University Medical Center
Guy Schoehn
Guy Schoehn Grenoble Alpes University
André M. Deelder
André M. Deelder Leiden University Medical Center
David A. Lomas
David A. Lomas University College London

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