James A. Huntington

Overview

Best Publications

• Structure of a serpin–protease complex shows inhibition by deformation

  James A. Huntington;Randy J. Read;Robin W. Carrell

  1411
  Citations

• Structure of the antithrombin–thrombin–heparin ternary complex reveals the antithrombotic mechanism of heparin

  Wei Li;Daniel J D Johnson;Charles T Esmon;James A Huntington

  467
  Citations

• Structure and properties of ovalbumin.

  James A. Huntington;Penelope E. Stein

  465
  Citations

• Serpins in thrombosis, hemostasis and fibrinolysis

  J. C. Rau;L. M. Beaulieu;J. A. Huntington;Frank C. Church

  440
  Citations

• Molecular recognition mechanisms of thrombin

  J. A. Huntington

  343
  Citations

• Serpin structure, function and dysfunction.

  J. A. Huntington

  338
  Citations

• How vitronectin binds PAI-1 to modulate fibrinolysis and cell migration

  Aiwu Zhou;James A Huntington;Navraj S Pannu;Navraj S Pannu;Robin W Carrell

  332
  Citations

• Crystal structure of a stable dimer reveals the molecular basis of serpin polymerization

  Masayuki Yamasaki;Wei Li;Daniel J. D. Johnson;James A. Huntington

  288
  Citations

• Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism

  Trevor P. Baglin;Robin W. Carrell;Frank C. Church;Charles T. Esmon

  250
  Citations

• Antithrombin–S195A factor Xa-heparin structure reveals the allosteric mechanism of antithrombin activation

  Daniel J D Johnson;Wei Li;Ty E Adams;James A Huntington

  222
  Citations

• Mechanisms of glycosaminoglycan activation of the serpins in hemostasis

  J. A. Huntington

  203
  Citations

• Crystal structure of thrombin bound to heparin

  Wendy J. Carter;Evis Cama;James A. Huntington

  190
  Citations

• Shape-shifting serpins--advantages of a mobile mechanism.

  James A. Huntington

  178
  Citations

• The Serpin Inhibitory Mechanism Is Critically Dependent on the Length of the Reactive Center Loop

  Aiwu Zhou;Robin W. Carrell;James A. Huntington

  173
  Citations

• Serpins flex their muscle: I. Putting the clamps on proteolysis in diverse biological systems.

  Gary A Silverman;James C Whisstock;Stephen Paul Bottomley;James A Huntington

  164
  Citations

• Design and characterization of an APC-specific serpin for the treatment of hemophilia

  Stéphanie G. I. Polderdijk;Ty E. Adams;Lacramioara Ivanciu;Rodney M. Camire

  163
  Citations

• Mechanism of Heparin Activation of Antithrombin. Evidence for Reactive Center Loop Preinsertion with Expulsion upon Heparin Binding

  James A. Huntington;Steven T. Olson;Bingqi Fan;Peter G. W. Gettins

  158
  Citations

• Molecular basis of α1‐antitrypsin deficiency revealed by the structure of a domain‐swapped trimer

  Masayuki Yamasaki;Timothy J Sendall;Mary C Pearce;James C Whisstock

  154
  Citations

• A 2.6 A structure of a serpin polymer and implications for conformational disease.

  James A Huntington;Navraj S Pannu;Bart Hazes;Randy J Read

  148
  Citations

• Implications for function and therapy of a 2.9 A structure of binary-complexed antithrombin.

  Richard Skinner;Wun-Shaing W Chang;Lei Jin;Xue Pei

  144
  Citations